Literature summary for 1.1.1.10 extracted from

Hollmann, S.; Touster, O.
The L-xylulose-xylitol enzyme and other polyol dehydrogenases of guinea pig liver mitochondria (1957), J. Biol. Chem., 225, 87-102.

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General Stability

General Stability	Organism
inactivation during dialysis	Cavia porcellus

Inhibitors

Inhibitors	Comment	Organism	Structure
iodoacetate	complete inhibition of L-xylulose reductive activity at 5 mM	Cavia porcellus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Cavia porcellus

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	guinea pig	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Cavia porcellus	-

Storage Stability

Storage Stability	Organism
2°C, aqueous solution, many weeks	Cavia porcellus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-xylulose + NADPH + H+	-	Cavia porcellus	L-xylitol + NADP+	-	r
xylitol + NADP+	-	Cavia porcellus	L-xylulose + NADPH + H+	-	r

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
50	-	20 min stable	Cavia porcellus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	approximately	Cavia porcellus

pH Stability

pH Stability	pH Stability Maximum	Comment	Organism
4	-	2°C, 2 h stable	Cavia porcellus
9	-	room temperature, several h stable	Cavia porcellus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	much less effective than NADP+	Cavia porcellus
NADP+	much more effective than NAD+	Cavia porcellus

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Release 2023.1 (January 2023)