Activating Compound | Comment | Organism | Structure |
---|---|---|---|
S-nitrosoglutathione | ADH3-mediated alcohol oxidation is promoted in the presence of S-nitrosoglutathione | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dodecanoic acid | inhibits ADH3 irrespective of substrate | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | 2 atoms are included in each 40 kDa subunit, while one of the zinc ions is considered to serve a structural function only, the other zinc ion functions as a Lewis acid and activates the substrate in the active site, which is located in a cleft between the catalytic and the coenzyme binding domain | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a primary alcohol + NAD+ | Mus musculus | ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM | an aldehyde + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | Mus musculus | - |
all-trans-retinal + NADH | - |
? | |
octanol + NAD+ | Mus musculus | - |
octanal + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
additional information | ADH3 is expressed ubiquitously and with relatively little inter-tissue variation in mammals, in contrast to other ADHs | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a primary alcohol + NAD+ | ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM | Mus musculus | an aldehyde + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | - |
Mus musculus | all-trans-retinal + NADH | - |
? | |
octanol + NAD+ | - |
Mus musculus | octanal + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADH | - |
Mus musculus |
ADH3 | - |
Mus musculus |
alcohol dehydrogenase 3 | - |
Mus musculus |
alcohol dependent dehydrogenase | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NADH | - |
Mus musculus |