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Literature summary for 1.1.1.1 extracted from

  • Fontaine, F.R.; Dunlop, R.A.; Petersen, D.R.; Burcham, P.C.
    Oxidative bioactivation of crotyl alcohol to the toxic endogenous aldehyde crotonaldehyde: association of protein carbonylation with toxicity in mouse hepatocytes (2002), Chem. Res. Toxicol., 15, 1051-1058.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Methylpyrazole
-
Equus caballus
4-Methylpyrazole inhibits cell protein carbonylation following exposure to crotyl alcohol Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Equus caballus
0.39
-
allyl alcohol pH 7.3, 37°C Equus caballus
0.71
-
crotyl alcohol pH 7.3, 37°C Equus caballus
2.46
-
ethanol pH 7.3, 37°C Equus caballus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
allyl alcohol + NAD+ Mus musculus
-
acrolein + NADH product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol ?
crotyl alcohol + NAD+ Mus musculus
-
crotonaldehyde + NADH product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol ?
crotyl alcohol + NAD+ Equus caballus product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol crotonaldehyde + NADH
-
?

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a primary alcohol + NAD+ = an aldehyde + NADH + H+ ordered sequential bibi reaction mechanism, modeling of oxidation kinetic mechanism Equus caballus

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Equus caballus
-
hepatocyte
-
Mus musculus
-
liver
-
Mus musculus
-
liver
-
Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
allyl alcohol + NAD+
-
Mus musculus acrolein + NADH
-
?
allyl alcohol + NAD+
-
Equus caballus acrolein + NADH
-
?
allyl alcohol + NAD+
-
Mus musculus acrolein + NADH product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol ?
crotyl alcohol + NAD+
-
Mus musculus crotonaldehyde + NADH
-
?
crotyl alcohol + NAD+
-
Equus caballus crotonaldehyde + NADH
-
?
crotyl alcohol + NAD+
-
Mus musculus crotonaldehyde + NADH product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol ?
crotyl alcohol + NAD+ product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol Equus caballus crotonaldehyde + NADH
-
?
ethanol + NAD+
-
Equus caballus acetaldehyde + NADH
-
?

Synonyms

Synonyms Comment Organism
ADH
-
Mus musculus
ADH
-
Equus caballus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Equus caballus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
assay at Equus caballus