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Literature summary for 1.1.1.1 extracted from
- New human liver alcohol dehydrogenase forms with unique kinetic characteristics (1981), Biochem. Biophys. Res. Commun., 98, 122-130.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Homo sapiens |  |
| 4-Methylpyrazole | no inhibition by 12 mM | Homo sapiens | |
| 8-hydroxyquinoline 5-sulfonic acid | - |
Homo sapiens | |
| dipicolinic acid | - |
Homo sapiens | |
| NADP+ | - |
Homo sapiens | |
| sulfonic acid | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
Octanol | - |
Homo sapiens | |
| 17 | - |
Hexanol | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | 3.6-4.2 gatom of zinc per mol | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 79000 | 84000 | ultracentrifugal analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethanol + NAD+ | Homo sapiens | chi-ADH plays an important role in the metabolism of long chain alcohols and aldehydes | acetaldehyde + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
chi-ADH | - |
| Homo sapiens | - |
anodic enzyme form | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.65 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethanol + NAD+ | chi-ADH plays an important role in the metabolism of long chain alcohols and aldehydes | Homo sapiens | acetaldehyde + NADH | - |
? | |
| hexanol + NAD+ | - |
Homo sapiens | n-hexanal + NADH | - |
? | |
| methanol + NAD+ | no activity | Homo sapiens | formaldehyde + NADH + H+ | - |
? | |
| octan-1-ol + NAD+ | - |
Homo sapiens | n-octanal + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NADH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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