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Literature summary for 1.1.1.1 extracted from

  • Dafeldecker, W.P.; Vallee, B.L.
    Organ-specific human alcohol dehydrogenase: isolation and characterization of isozymes from testis (1986), Biochem. Biophys. Res. Commun., 134, 1056-1063.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Methylpyrazole class III enzyme is completely insensitive to inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.056
-
12-Hydroxydodecanoic acid
-
Homo sapiens
0.55
-
1-Octanol
-
Homo sapiens
27
-
1-Pentanol
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
x * 40000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
class III isoenzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
testis the class III enzyme contributes by far the bulk of the total alcohol dehydrogenase activity Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxydodecanoate + NAD+
-
Homo sapiens 12-oxododecanoic acid + NADH
-
?
ethanol + NAD+ no oxidation with class III enzyme Homo sapiens acetaldehyde + NADH
-
?
methanol + NAD+ no activity with class III enzyme Homo sapiens formaldehyde + NADH + H+
-
?
octan-1-ol + NAD+
-
Homo sapiens n-octanal + NADH
-
?
pentanol + NAD+
-
Homo sapiens n-pentanal + NADH
-
?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.183
-
1-Pentanol
-
Homo sapiens
0.333
-
12-Hydroxydodecanoic acid
-
Homo sapiens
2.83
-
1-Octanol
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens