Ligand L-methionine sulfoximine

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Basic Ligand Information

Molecular Structure
Picture of L-methionine sulfoximine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H12N2O3S
L-methionine sulfoximine
SXTAYKAGBXMACB-DPVSGNNYSA-N
Synonyms:
(2S)-2-amino-4-(S-methylsulfonimidoyl)butanoic acid, L-methionine-(S,R)-sulfoximine, L-methionine-(S,R)-sulphoximine, L-methionine-DL-sulfoximine, L-methionine-DL-sulphoximine, L-methionine-S-sulfoximine, L-methionine-SR-sulfoxime, L-methionine-SR-sulfoximine, L-methionine-sulfoximine, L-methionine D,L-sulfoximine, L-methionine DL-sulfoximine, L-methionine S-sulfoximine, methionine sulfone amine, methionine sulfoximine

Show all pahtways known for Show all pathways known for L-methionine sulfoximine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + L-methionine sulfoximine = ?
show the reaction diagram
-
L-methionine sulfoximine + glyoxylate = (S-methylsulfonimidoyl)-2-oxobutanoate + glycine
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
very slight activation
-

Inhibitor in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 12.6% inhibition
-
asparagine/pyruvate reaction
-
competitive with L-glutamate
-
about 21% inhibition at about 1 mM
-
competitive inhibition
-
partial
-
at 1 mM, 3 mM or 5 mM, 20% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (10 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.146
-
-

IC50 Value (11 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for L-methionine sulfoximine

ChEBI
PubChem
ChEBI
PubChem