Acknowledgements

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The development and curation of BRENDA is funded by the European Commission under SLING, grant agreement number 226073 (Integrating Activity) within Research Infrastructures Action of the FP7 Capacities Specific Programme.

Until February 2011 the curation and development of BRENDA was funded by European Union under FELICS (Free European Life-Science Information and Computational Services), grant number 021902 (RII3).
We thank Peter Ertl, Novartis for his courtesy to employ the JME Editor in the substructure search.

We are grateful to

- the developers of the Chemistry Development Kit (CDK)
Publication: The Chemistry Development Kit (CDK): An Open-Source Java Library for Chemo- and Bioinformatics. Steinbeck, C., Han, Y., Kuhn, S., Horlacher, O., Luttmann, E., and Willighagen, E.L., J. Chem. Inf. Comput. Sci. 2003, 43(2):493-500,

- the developers of MySQL
(Sun Microsystems GmbH, Sonnenallee 1, D-85551 Kirchheim-Heimstetten, Germany),

- and the developers of TMHMM, curated at the Center for Biological Sequence Analysis Department of Systems Biology Technical University of Denmark Kemitorvet, Building 208 DK-2800 Lyngby Denmark
Publication: A hidden Markov model for predicting transmembrane helices in protein sequences. Sonnhammer, E.L., von Heijne, G., and Krogh, A., Proc Int Conf. Intell. Syst. Mol. Biol. 1998, 6, 175-82


For the contribution of data and links we express our thanks to

- UniProt (Universal Protein Resource)
Publication: The Universal Protein Resource (UniProt) 2009. The UniProt Consortium, Nucleic Acids Res. 2009, 37, D169-D174

- MetaCyc (Encyclopedia of Metabolic Pathways)
Publication: The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases. Caspi, R., Foerster, H., Fulcher, C.A., Kaipa, P., Krummenacker, M., Latendresse, M., Paley, S., Rhee, S.Y., Shearer, A.G., Tissier, C., Walk, T.C., Zhang, P., and Karp, P.D. Nucleic Acids Res. 2008, 36: D623-D631

- KEGG (Kyoto Encyclopedia of Genes and Genomes)
Publication: KEGG for linking genomes to life and the environment. Kanehisa, M., Araki, M., Goto, S., Hattori, M., Hirakawa, M., Itoh, M., Katayama, T., Kawashima, S., Okuda, S., Tokimatsu, T., and Yamanishi, Y. Nucleic Acids Res. 2008, 36: D480-D484

- PDB (Protein Data Bank)
Publication: The RCSB PDB information portal for structural genomics. Kouranov, A., Xie, L., de la Cruz, J., Chen, L., Westbrook, J., Bourne, P.E., and Berman, H.M. Nucleic Acids Res. 2006, 34: D302-D305

- ChEBI (Chemical Entities of Biological Interest )
Publication: ChEBI: a database and ontology for chemical entities of biological interest. Degtyarenko, K., de Matos, P., Ennis, M., Hastings, J., Zbinden, M., McNaught, A., Alcántara, R., Darsow, M., Guedj, M., and Ashburner, M. Nucleic Acids Res. 2008, 36: D344-D350