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Information on EC 7.1.1.2 - NADH:ubiquinone reductase (H+-translocating) and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
The enzyme is a very large complex that participates in electron transfer chains of mitochondria and aerobic bacteria, transferring electrons from NADH to the ubiquinone pool. Reversed electron transport through this enzyme can reduce NAD+ to NADH.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
complex i, complex 1, nadh dehydrogenase, mitochondrial complex i, grim-19, respiratory complex i, respiratory chain complex i, nadh:ubiquinone oxidoreductase, mitochondrial nadh dehydrogenase, ndh-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
13 kDa differentiation-associated protein
-
-
-
-
CDA016
-
-
-
-
Cell adhesion protein SQM1
-
-
-
-
Cell death-regulatory protein GRIM-19
-
-
-
-
CGI-39
-
-
-
-
CI-11KD
-
-
-
-
CI-12KD
-
-
-
-
CI-14.8KD
-
-
-
-
CI-14KD
-
-
-
-
CI-15 kDa
-
-
-
-
CI-16KD
-
-
-
-
CI-17.3KD
-
-
-
-
CI-17.8KD
-
-
-
-
CI-18 kDa
-
-
-
-
CI-18Kd
-
-
-
-
CI-19.3KD
-
-
-
-
CI-19KD
-
-
-
-
CI-20KD
-
-
-
-
CI-21KD
-
-
-
-
CI-22.5Kd
-
-
-
-
CI-23KD
-
-
-
-
CI-27KD
-
-
-
-
CI-28.5KD
-
-
-
-
CI-29.9KD
-
-
-
-
CI-29KD
-
-
-
-
CI-30KD
-
-
-
-
CI-31KD
-
-
-
-
CI-38.5KD
-
-
-
-
CI-39KD
-
-
-
-
CI-40KD
-
-
-
-
CI-42.5KD
-
-
-
-
CI-42KD
-
-
-
-
CI-49KD
-
-
-
-
CI-51KD
-
-
-
-
CI-75KD
-
-
-
-
CI-78KD
-
-
-
-
CI-9.5
-
-
-
-
CI-9KD
-
-
-
-
CI-AGGG
-
-
-
-
CI-AQDQ
-
-
-
-
CI-ASHI
-
-
-
-
CI-B12
-
-
-
-
CI-B14
-
-
-
-
CI-B14.5a
-
-
-
-
CI-B14.5b
-
-
-
-
CI-B15
-
-
-
-
CI-B16.6
-
-
-
-
CI-B17
-
-
-
-
CI-B17.2
-
-
-
-
CI-B18
-
-
-
-
CI-B22
-
-
-
-
CI-B8
-
-
-
-
CI-B9
-
-
-
-
CI-KFYI
-
-
-
-
CI-MLRQ
-
-
-
-
CI-MNLL
-
-
-
-
CI-MWFE
-
-
-
-
CI-PDSW
-
-
-
-
CI-PGIV
-
-
-
-
CI-SGDH
-
-
-
-
CIB17.2
-
-
-
-
coenzyme Q reductase
-
-
-
-
complex I (electron transport chain)
-
-
-
-
complex I (mitochondrial electron transport)
-
-
-
-
complex I (NADH:Q1 oxidoreductase)
-
-
-
-
complex I dehydrogenase
-
-
-
-
Complex I-11KD
-
-
-
-
Complex I-12KD
-
-
-
-
Complex I-14.8KD
-
-
-
-
Complex I-14KD
-
-
-
-
Complex I-15 kDa
-
-
-
-
Complex I-16KD
-
-
-
-
Complex I-17.3KD
-
-
-
-
Complex I-17.8KD
-
-
-
-
Complex I-18 kDa
-
-
-
-
Complex I-18Kd
-
-
-
-
Complex I-19.3KD
-
-
-
-
Complex I-19KD
-
-
-
-
Complex I-20KD
-
-
-
-
Complex I-21KD
-
-
-
-
Complex I-22.5Kd
-
-
-
-
Complex I-23KD
-
-
-
-
Complex I-27KD
-
-
-
-
Complex I-28.5KD
-
-
-
-
Complex I-29.9KD
-
-
-
-
Complex I-29KD
-
-
-
-
Complex I-30KD
-
-
-
-
Complex I-38.5KD
-
-
-
-
Complex I-39KD
-
-
-
-
Complex I-40KD
-
-
-
-
Complex I-42.5KD
-
-
-
-
Complex I-42KD
-
-
-
-
Complex I-49KD
-
-
-
-
Complex I-51KD
-
-
-
-
Complex I-75KD
-
-
-
-
Complex I-78KD
-
-
-
-
Complex I-9.5KD
-
-
-
-
Complex I-9KD
-
-
-
-
Complex I-AGGG
-
-
-
-
Complex I-AQDQ
-
-
-
-
Complex I-ASHI
-
-
-
-
Complex I-B12
-
-
-
-
Complex I-B14
-
-
-
-
Complex I-B14.5a
-
-
-
-
Complex I-B14.5b
-
-
-
-
Complex I-B15
-
-
-
-
Complex I-B16.6
-
-
-
-
Complex I-B17
-
-
-
-
Complex I-B17.2
-
-
-
-
Complex I-B18
-
-
-
-
Complex I-B22
-
-
-
-
Complex I-B8
-
-
-
-
Complex I-B9
-
-
-
-
Complex I-KFYI
-
-
-
-
Complex I-MLRQ
-
-
-
-
Complex I-MNLL
-
-
-
-
Complex I-MWFE
-
-
-
-
Complex I-PDSW
-
-
-
-
Complex I-PGIV
-
-
-
-
Complex I-SGDH
-
-
-
-
dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
-
-
-
-
DPNH-coenzyme Q reductase
-
-
-
-
DPNH-ubiquinone reductase
-
-
-
-
electron transfer complex I
-
-
-
-
Gene associated with retinoic-interferon-induced mortality 19 protein
-
-
-
-
GGHPW
-
-
-
-
GRIM-19
-
-
-
-
Hypothetical protein Walter
-
-
-
-
Internal NADH dehydrogenase
-
-
-
-
mitochondrial electron transport complex 1
-
-
-
-
mitochondrial electron transport complex I
-
-
-
-
NADH coenzyme Q1 reductase
-
-
-
-
NADH-coenzyme Q oxidoreductase
-
-
-
-
NADH-coenzyme Q reductase
-
-
-
-
NADH-CoQ oxidoreductase
-
-
-
-
NADH-CoQ reductase
-
-
-
-
NADH-ferricyanide reductase
-
-
-
-
NADH-Q6 oxidoreductase
-
-
-
-
NADH-quinone reductase
-
-
-
-
NADH-ubiquinone oxidoreductase
-
-
-
-
NADH-ubiquinone reductase
-
-
-
-
NADH-ubiquinone-1 reductase
-
-
-
-
NADH:Q oxidoreductase
-
-
-
-
NADH:ubiquinone oxidoreductase
-
-
NADH:ubiquinone oxidoreductase complex
-
-
-
-
Protein P1
-
-
-
-
reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
-
-
-
-
reductase, ubiquinone
-
-
-
-
type I dehydrogenase
-
-
-
-
ubiquinone reductase
-
-
-
-
Ubiquinone-binding protein
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
NADH:ubiquinone oxidoreductase
The enzyme is a very large complex that participates in electron transfer chains of mitochondria and aerobic bacteria, transferring electrons from NADH to the ubiquinone pool. Reversed electron transport through this enzyme can reduce NAD+ to NADH.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-04-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
NADH + ubiquinone
NAD+ + ubiquinol
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NU4M_DROME
446
12
51448
Swiss-Prot
Secretory Pathway (Reliability: 1)
NDUS3_DROME
265
0
29971
Swiss-Prot
Mitochondrion (Reliability: 2)
NU3M_DROME
117
3
13564
Swiss-Prot
Secretory Pathway (Reliability: 1)
NU6M_DROME
174
4
20075
Swiss-Prot
Secretory Pathway (Reliability: 1)
NDUS8_DROME
217
0
24578
Swiss-Prot
Mitochondrion (Reliability: 2)
NU1M_DROME
312
8
35957
Swiss-Prot
Secretory Pathway (Reliability: 1)
NU4LM_DROME
96
3
11359
Swiss-Prot
Secretory Pathway (Reliability: 1)
NDUS1_DROME
731
0
78630
Swiss-Prot
Mitochondrion (Reliability: 2)
NU5M_DROME
572
16
65145
Swiss-Prot
Secretory Pathway (Reliability: 1)
NU2M_DROME
341
9
39823
Swiss-Prot
Secretory Pathway (Reliability: 1)
B2LAQ0_DROME
115
2
12907
TrEMBL
other Location (Reliability: 4)
Q9MJC6_DROME
132
3
15446
TrEMBL
Secretory Pathway (Reliability: 3)
A0A0K0K2A6_DROME
303
8
34227
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C8_DROME
427
9
47909
TrEMBL
Secretory Pathway (Reliability: 1)
J7FM77_DROME
312
8
35997
TrEMBL
Secretory Pathway (Reliability: 1)
A1Z9Z7_DROME
481
0
53778
TrEMBL
other Location (Reliability: 4)
A0A1S6KXC0_DROME
341
9
39791
TrEMBL
Secretory Pathway (Reliability: 1)
Q05GI6_DROME
232
6
25848
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2D2_DROME
424
12
48725
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2F2_DROME
207
5
22879
TrEMBL
Secretory Pathway (Reliability: 5)
A0A097F8G0_DROME
172
5
18886
TrEMBL
Secretory Pathway (Reliability: 3)
J3XQC1_DROME
341
9
39823
TrEMBL
Secretory Pathway (Reliability: 1)
M4N5J3_DROME
153
4
17770
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K283_DROME
87
2
10207
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2F1_DROME
84
2
9876
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VTB4_DROME
124
0
13788
TrEMBL
Mitochondrion (Reliability: 5)
A0A0K0K292_DROME
445
12
51244
TrEMBL
Secretory Pathway (Reliability: 1)
J7FNN7_DROME
174
4
20151
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C0_DROME
289
8
32489
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VPE2_DROME
416
0
46822
TrEMBL
Mitochondrion (Reliability: 5)
A0A0K0K295_DROME
87
2
10280
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C3_DROME
299
8
33715
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2D5_DROME
445
12
51195
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2F9_DROME
433
11
48869
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2E0_DROME
96
3
11452
TrEMBL
Secretory Pathway (Reliability: 1)
B6UNH5_DROME
170
4
19482
TrEMBL
Secretory Pathway (Reliability: 5)
J9TI24_DROME
312
8
35924
TrEMBL
Secretory Pathway (Reliability: 1)
Q05GI5_DROME
212
5
24103
TrEMBL
other Location (Reliability: 4)
A0A2Z6G1H4_DROME
117
3
12867
TrEMBL
Secretory Pathway (Reliability: 1)
B6E0Q1_DROME
96
3
11359
TrEMBL
Secretory Pathway (Reliability: 1)
J7FKZ6_DROME
117
3
13550
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1S6KX82_DROME
572
16
65175
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C4_DROME
445
12
51246
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2A8_DROME
441
8
50309
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1S6KXE7_DROME
572
16
65223
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2A1_DROME
94
3
11083
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2D7_DROME
309
8
34736
TrEMBL
Secretory Pathway (Reliability: 1)
Q9VMI3_DROME
474
0
51831
TrEMBL
Mitochondrion (Reliability: 4)
A0A097F882_DROME
137
4
15839
TrEMBL
Secretory Pathway (Reliability: 5)
A0A343ASV4_DROME
312
8
35909
TrEMBL
Secretory Pathway (Reliability: 1)
B6E0Q2_DROME
174
4
20075
TrEMBL
Secretory Pathway (Reliability: 1)
M4NAR6_DROME
166
4
20237
TrEMBL
Secretory Pathway (Reliability: 1)
B6E0R2_DROME
572
16
65145
TrEMBL
Secretory Pathway (Reliability: 1)
A0A075E721_DROME
446
12
51448
TrEMBL
Secretory Pathway (Reliability: 1)
J7FL05_DROME
341
9
39823
TrEMBL
Secretory Pathway (Reliability: 1)
Q9MGN3_DROME
312
8
35957
TrEMBL
Secretory Pathway (Reliability: 1)
B2YEQ1_DROME
206
6
24708
TrEMBL
Secretory Pathway (Reliability: 1)
C7DZL9_DROME
315
8
36367
TrEMBL
Secretory Pathway (Reliability: 1)
B1PTQ3_DROME
217
5
25460
TrEMBL
Secretory Pathway (Reliability: 5)
A0A0K0K2B2_DROME
443
6
50258
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0M3R6X1_DROME
338
9
39492
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2F3_DROME
283
7
31847
TrEMBL
Secretory Pathway (Reliability: 3)
M4N863_DROME
166
4
20222
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C9_DROME
91
2
10677
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2E1_DROME
446
12
51267
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2G3_DROME
446
12
51315
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R7DWM7_DROME
572
16
65172
TrEMBL
Secretory Pathway (Reliability: 1)
Q9MDK5_DROME
446
12
51357
TrEMBL
Secretory Pathway (Reliability: 1)
Q9MGN8_DROME
312
8
35925
TrEMBL
Secretory Pathway (Reliability: 1)
B6E0W4_DROME
572
16
65171
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K291_DROME
96
3
11305
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K287_DROME
314
8
35500
TrEMBL
Secretory Pathway (Reliability: 1)
B6E0W5_DROME
446
12
51371
TrEMBL
Secretory Pathway (Reliability: 1)
M4N715_DROME
166
4
20204
TrEMBL
Secretory Pathway (Reliability: 1)
M4N5P3_DROME
168
4
18417
TrEMBL
Secretory Pathway (Reliability: 3)
B6E0P9_DROME
572
16
65163
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2F5_DROME
94
3
11135
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2B5_DROME
86
3
10109
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0A0RZ67_DROME
572
16
65118
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C7_DROME
446
12
51353
TrEMBL
Secretory Pathway (Reliability: 1)
B6E0T9_DROME
446
12
51371
TrEMBL
Secretory Pathway (Reliability: 1)
Q8SYJ2_DROME
83
1
9434
TrEMBL
other Location (Reliability: 5)
J7FM75_DROME
574
16
65315
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2E4_DROME
297
8
33489
TrEMBL
Secretory Pathway (Reliability: 1)
M4N8B8_DROME
153
4
17756
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2E3_DROME
361
11
41635
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2I8_DROME
446
12
50512
TrEMBL
Secretory Pathway (Reliability: 1)
A1Z9Z6_DROME
462
0
51915
TrEMBL
other Location (Reliability: 4)
B6E0P8_DROME
117
3
13564
TrEMBL
Secretory Pathway (Reliability: 1)
B2YEQ2_DROME
96
3
11533
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1S6KXC2_DROME
174
4
20076
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2G9_DROME
446
12
51311
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2I3_DROME
87
2
10143
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2C5_DROME
93
3
11001
TrEMBL
Secretory Pathway (Reliability: 1)
M4N6Z3_DROME
166
4
20204
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2B7_DROME
89
2
10408
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R7DUF1_DROME
341
9
39849
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2E5_DROME
446
12
51353
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2A4_DROME
441
10
49457
TrEMBL
Secretory Pathway (Reliability: 1)
M4N593_DROME
166
4
20218
TrEMBL
Secretory Pathway (Reliability: 1)
C7DZL4_DROME
577
16
65749
TrEMBL
Secretory Pathway (Reliability: 1)
Q7GHL2_DROME
153
4
18760
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0R7DUM3_DROME
341
9
39807
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1W6LRC6_DROME
572
16
65191
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2J4_DROME
446
12
51297
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2D3_DROME
439
8
49166
TrEMBL
Secretory Pathway (Reliability: 4)
B6UNI3_DROME
170
4
19450
TrEMBL
Secretory Pathway (Reliability: 5)
Q9G472_DROME
91
3
9706
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0K0K2B3_DROME
442
11
50015
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0K0K2G8_DROME
193
5
21546
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2A0_DROME
320
7
36072
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2E9_DROME
96
3
11314
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K296_DROME
441
12
49777
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0K0K2B9_DROME
87
2
10173
TrEMBL
Secretory Pathway (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gabaldon, T.; Rainey, D.; Huynen, M.A.
Tracing the evolution of a large protein complex in the eukaryotes, NADH:ubiquinone oxidoreductase (Complex I)
J. Mol. Biol.
348
857-870
2005
Anopheles gambiae, Arabidopsis thaliana, Bos taurus, Saccharomyces cerevisiae, Caenorhabditis elegans, Candida albicans, Yarrowia lipolytica, Chlamydomonas reinhardtii, Drosophila melanogaster, Homo sapiens, Mus musculus, Neurospora crassa, Plasmodium falciparum, Schizosaccharomyces pombe, Takifugu rubripes, Cryptosporidium hominis, Encephalitozoon cuniculi, Guillardia theta
Manually annotated by BRENDA team