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Information on EC 6.4.1.2 - acetyl-CoA carboxylase and Organism(s) Homo sapiens
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6.4.1.2 acetyl-CoA carboxylaseIUBMB Comments
This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
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Word Map
- 6.4.1.2
-
amp-activated
- triglyceride
-
lipogenesis
- adipose
-
lipogenic
- sterol
- peroxisome
- cholesterol
- obesity
- carnitine
- malonyl-coa
-
proliferator-activated
-
high-fat
- adipocytes
- lipoprotein
-
element-binding
- biotin
- steatosis
- lipase
-
obese
-
herbicide
- srebp-1c
- triacylglycerols
-
diet-induced
- stearoyl-coa
-
malic
- adiponectin
- nafld
-
lipolysis
-
monophosphate-activated
-
hfd-induced
- protein-1c
-
weed
- carboxylases
- aicar
-
atp-citrate
-
malonyl
-
desaturase-1
-
anti-obesity
-
biotin-dependent
-
hormone-sensitive
-
chrebp
-
5'-amp-activated
-
palmitoyltransferase-1
-
target-site
- adenoid
-
srebf1
-
anti-adipogenic
- lolium
- biotechnology
- medicine
-
herbicide-resistant
- pharmacology
- synthesis
- drug development
- biofuel production
- agriculture
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
acetyl-coa carboxylase, accase, acetyl coa carboxylase, acetyl-coenzyme a carboxylase, acaca, acc-2, acetyl coenzyme a carboxylase, acetyl-coa carboxylase 1, acc-1, acacb, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ACC
ACC1
ACC2
AccA
ACCase
-
-
-
-
Acetyl CoA carboxylase
Acetyl coenzyme A carboxylase
-
-
-
-
acetyl-CoA carboxylase
acetyl-CoA carboxylase 2
Acetyl-coenzyme A carboxylase
Carboxylase, acetyl coenzyme A
-
-
-
-
additional information
Acetyl CoA carboxylase
-
-
-
-
Acetyl-coenzyme A carboxylase
-
-
-
-
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme proceeds through a hybrid (two-site) random Ter Ter mechanism, one that likely involves a two-step reaction at the biotin carboxylase domain
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
carboxylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
KEGG
-
-, -
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:hydrogencarbonate ligase (ADP-forming)
This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
CAS REGISTRY NUMBER
COMMENTARY
9023-93-2
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
?
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
?
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
?
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
?
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(+)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]methoxybenzoic acid
-
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
-
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
-
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
-
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
-
-
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
-
-
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-(4-[[2-amino-6-(trifluoromethyl)-1-benzothiophen-3-yl]carbonyl]piperazin-1-yl)piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
selective and potent ACC1 inhibitor, shows acceptable solubility and CYP inhibition profiles. Oral administration significantly reduces the concentration of malonyl-CoA in HCT-116 xenograft tumors at doses of more than 30 mg/kg
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
-
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
-
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
-
-
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
-
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
-
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
-
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
-
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
-
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
-
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
-
1-ethyl-3-[3-[(4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1-benzothiophen-2-yl]urea
-
-
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
-
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
-
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
-
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
-
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
-
-
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
-
-
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
-
-
2'-tert-butyl-1-(1H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
-
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
-
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
-
-
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
-
5-[1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]pyridine-3-carboxylic acid
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
BODIPY-soraphen A
a soraphen A derivative, shows high activity against ACC2, synthesis, overview. BODIPY-soraphen A directly binds to the BC domain of the ACC enzyme by causing a 10°C increase in thermal stability of the protein using a differential scanning calorimetry assay
BRCA1 protein
-
BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction
-
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
-
-
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
-
-
N-(1-(2,2'-dimethyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)-1H-pyrazole-4-carboxamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)cyclopropanecarboxamide
-
-
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
-
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
-
N-(3-[2-(2-chloro-4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
-
moderate selective isoform ACC2 inhibitor
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
-
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
-
-
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
-
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
-
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
-
-
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
-
-
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]-carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]-methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
-
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
-
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
i.e. CP-640186
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
-
CP-640186
-
inhibition of both isozymes Acc1 and Acc2, an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
herbicide, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure, binds to the biotin binding site
malonyl-CoA
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
potent and selective inhibitor
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
inhibitor reduces the levels of malonyl-CoA in endothelial cells
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, overview, FOP herbicides are weak inhibitors of the human enzyme
-
additional information
-
product inhibition analysis, inhibition patterns, overview
-
additional information
-
synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases containing biphenyl or 3-phenyl pyridine cores
-
additional information
-
disubstituted (4-piperidinyl)-piperazine derivatives act as ACC1/2 non-selective inhibitors
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, effectively reduces ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells, overview
-
additional information
-
inhibition of stearoyl-CoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells, overview
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
citrate
-
activates both by increasing kcat and kcat/KM for ATP and acetyl-CoA, has a putative regulatory function on ACC2
citrate
allosteric activation, presence of citrate leads to dose-dependent formation of dimers and tetramers
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
human cytomegalovirus infection also induces isoform ACC1's enzymatic activity
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
steady-state kinetic analysis of ACC2, kinetic mechanism, overview
-
0.0002
acetyl-CoA
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
0.052
ATP
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.155
ATP
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
0.192
acetyl-CoA
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
dissociation constants of inhibitors CP-640186 and CP-640188
-
additional information
additional information
-
product inhibition kinetics, detailed overview
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00029
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000157
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000155
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000248
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000869
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000434
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000178 - 0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.000789 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
0.000071 - 0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.00258 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
0.000273 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
0.00183 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
0.000246 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
0.000335 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
0.000486 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
0.000227 - 0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
0.000355 - 0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
0.000231 - 0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000244 - 0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000037 - 0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000258 - 0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000159 - 0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000075
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.001
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.001
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000061
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000045
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000076
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000031
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000062
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000027
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000058 - 0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
0.000045
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000041
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000012
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000038
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00000058
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
Homo sapiens
pH 7.5, 22°C
0.00017 - 0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000022 - 0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000043 - 0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000048 - 0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00013 - 0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.0002 - 0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.0000049 - 0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
0.0000061 - 0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
0.0000059 - 0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
0.001864
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000242
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0000081 - 0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.000043 - 0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00002 - 0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000023 - 0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000014 - 0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000016 - 0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000027 - 0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
0.000049 - 0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000075 - 0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000184
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000052
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000068
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000076
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000102
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
Homo sapiens
-
ACC1/2
0.000169
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
Homo sapiens
-
ACC1/2
0.000126
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000115
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
Homo sapiens
-
ACC1/2
0.000076
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000127
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000069
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000057
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000032
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000037
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000021
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000055
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000059
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000169
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000061
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000049
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000036
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000048
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000105
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000166 - 0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
0.000391 - 0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000037 - 0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
0.000079 - 0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000207
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000597
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032 - 0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000033 - 0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000064 - 0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000051 - 0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000022 - 0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00004 - 0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000144
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000015 - 0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000009 - 0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000017
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000018 - 0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.0000045
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.0000085 - 0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000013 - 0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
0.0000044 - 0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
0.000015 - 0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000109
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000081
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000049
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000017 - 0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000017 - 0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000074
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
ACC1/2
0.0001
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000072
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000027
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00007
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000084
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.001
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00013
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000073
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.000067
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.00075 - 0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
0.01
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000169
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000095
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000151
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.00008
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000012 - 0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000019 - 0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000051 - 0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000065
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-{[2-(pyridin-2-yl)-1H-benzimidazol-6-yl]carbonyl}spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016 - 0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
0.000011 - 0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
0.000054
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000097
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000064
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00006
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000091
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000095
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000161
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000239
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000121
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.00007 - 0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.000076
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000244
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000052
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000055
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0014 - 0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.000102
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000175
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00025 - 0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.00162
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
Homo sapiens
-
isozyme ACC2
0.00616
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000018
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000009
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000014
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000013
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00021
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00013
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00038
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00029
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0000044 - 0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00007
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00001
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00081
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000057
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000067
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00037
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035 - 0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000054 - 0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
0.000036 - 0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
0.000348 - 0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
0.001
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0158
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000035
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000069
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000012
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000029
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000034
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00014
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000042
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000011
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00026
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000026
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000005 - 0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000013
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000007
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00063 - 0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019 - 0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.000259 - 0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
0.000013
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000119
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00004 - 0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.000024 - 0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.03
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0078 - 0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00006 - 0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.0002 - 0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.000015 - 0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00008 - 0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00006 - 0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.00014 - 0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
0.00196
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00015
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000076
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00011
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000004
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00405
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00007 - 0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.00131
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00132
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00085
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000037
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.0017
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00047
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00034
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00057
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00019 - 0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.000411
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000028
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00006
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0029
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000099 - 0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.000024
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0025
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00057 - 0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
0.0058 - 0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
0.0045 - 0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00024
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089 - 0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00073 - 0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00023 - 0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0017
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069 - 0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00033
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0038
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00021
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013 - 0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00021
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0011
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024 - 0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.000052
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00063 - 0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00011 - 0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.01
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00068
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0063
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0036
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000693
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
Homo sapiens
-
ACC1/2
0.03
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
Homo sapiens
-
isozyme ACC2
0.0265
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
Homo sapiens
-
isozyme ACC2
0.0099
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0017
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000178
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000789
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000071
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00258
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000273
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.00183
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000246
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000335
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000486
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000227
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000355
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000231
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000244
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000258
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000159
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000058
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00017
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00013
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0002
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000049
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000061
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000059
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0000081
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00002
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000023
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000014
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000016
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000027
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000049
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000166
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000391
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000079
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000032
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000033
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000064
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00004
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000009
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000018
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.0000085
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000013
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000044
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00184
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.00206
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000718
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000753
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000188
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000214
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.00075
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000126
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00146
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.000841
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00428
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.000012
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000019
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000051
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000011
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.00007
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00028
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00059
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000066
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.002112
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.0014
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00025
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000089
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000035
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000113
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.000017
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000033
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.0000044
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000054
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000036
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC1
0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC2
0.000296
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC1
0.00055
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC2
0.000348
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000005
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.025
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00265
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00063
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000259
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
value above, pH and temperature not specified in the publication
0.00004
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000024
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0078
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0099
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0023
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0001
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00092
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0018
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000015
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00003
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00017
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00036
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00038
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
IC50 above 0.01 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC1
0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC2
0.00128
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00007
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.014
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0074
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.02
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00075
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00178
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00452
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0067
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0127
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00062
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00067
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0057
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.011
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000099
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00057
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0058
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00073
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00063
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00011
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
1.336
recombinant N-terminal deletion mutant treated with Lambda protein phosphatase, pH 7.4, 37°C
1.363
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 5 mM citrate
2.246
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 10 mM citrate
4.186
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 20 mM citrate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
isozyme ACC2; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
ACC1 is the predominant isoform in human umbilical vein endothelial cells as well as in human microvascular endothelial cells
-
ACC and other lipogenic enzymes are present n the hypothalamus, the human tissue shows 2-3fold lower actiivity compared to the rat tissue
-
circulating, of nondiabetic and type 2 diabetic individuals, female and male
additional information
additional information
-
ACC1 is found primarily in lipogenic tissues such as the liver and adipose tissue whereas ACC2 is the predominate form found in oxidative tissues, skeletal muscle and heart
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
the enzyme is anchored to the outer membrane of the mitochondrion
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
inhibition of ACC1 through either RNA interference or inhibitor treatment (0.01 mg/ml 5-tetradecyloxy-2-furoic acid) attenuates human cytomegalovirus replication
metabolism
physiological function
metabolism
-
acetyl-CoA carboxylase is the rate limiting enzyme in de novo lipid synthesis
physiological function
-
acetyl-CoA carboxylase plays important roles in modulating energy metabolism
physiological function
inactivation of the putative mitochondrial targeting sequence leads to decreased lipoylation and mitochondrial fragmentation
physiological function
inhibition of Acc1 in endotheial cells shifts the lipid composition of membranes. Membrane fluidity, filopodia formation, and migratory capacity are reduced. The antimigratory action of inhibition depends on an increase in the cellular proportion of polyunsaturated fatty acids and on a decreased level of phosphatidylglycerol
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ACACA_HUMAN
2346
0
265554
Swiss-Prot
other Location (Reliability: 1)
ACACB_HUMAN
2458
1
276541
Swiss-Prot
Secretory Pathway (Reliability: 2)
A0A024R0Y2_HUMAN
2268
0
257239
TrEMBL
other Location (Reliability: 4)
A2NX49_HUMAN
2339
0
264548
TrEMBL
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
250000
265000
280000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
additional information
additional information
-
a large, multi-domain single polypeptide enzyme which forms complexes of several protomers, domain organization, overview, polymerization is promoted by citrate, isocitrate, malonate, sulfate, and phosphate, while long-chain fatty acids promote the complex dissociation
additional information
domain structure and organization, evolution and functional domains, overview
additional information
domain structure and organization, evolution and functional domains, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
phosphoprotein
-
Acc1 and Acc2 can be phosphorylated by protein kinase A and cAMP depndent protein kinase, overview
phosphoprotein
reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview
phosphoprotein
-
ACC is phosphorylated at Ser79 and thereby inactivated by AMP-activated protein kinase, AMPK, which is induced by UV light and H2O2. AMPK phosphorylates both isozymes of ACC, ACC1 and ACC2
phosphoprotein
-
Ser1263 of ACCA is phosphorylated in vivo, in a cell cycle-dependent manner, by the BRCA1 protein leading to reduced ACCA activity, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
phosphoprotein
phosphorylation decreases ACC2 catalytic activity whereas dephosphorylation activates the enzymatic function by 2fold. Recombinant protein expressed in Bombyx mori exhibits posttranslational phosphorylation
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
deletion of the N-terminal 148 hydrophobic amino acids to enhance the solubility of heterologous protein expressed in Bomby mori. Expression of the deletion mutant leads to a high yield of recombinant protein
additional information
-
deletion of the N-terminal 148 hydrophobic amino acids to enhance the solubility of heterologous protein expressed in Bomby mori. Expression of the deletion mutant leads to a high yield of recombinant protein
ORGANIC SOLVENT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Glycerol
20 and 30% glycerol can stabilize the enzyme for a period up to 4 weeks
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, in 20 mM Tris-HCl (pH 7.5) containing 0.3M NaCl, 10% glycerol, and 5 mM DTT, 4 days, rapid loss of activity
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
c-Myc-5 monoclonal IgG column chromatography and Sephacryl S-300 gel filtration
Ni affinity resin column chromatography, Q Sepharose HP column chromatography, and Superdex 200 gel filtration
recombinant enzyme from Sf9 insect cells by ammonium sulfate fractionation and anion exchange chromatography
-
recombinant His-tagged carboxyltransferase domain comprising residues 1548-2346 from Escherichia coli by nickel affinity and ion exchange chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, alternative splicing, the gene encoding isozyme ACC-beta is located on chromosome 12q24, overview
expressed in baculovirus-infected High Five insect cells as N-terminal His-tagged fusion proteins
-
expression analysis of biotin-related genes in leukocytes related to biotin deficiency, overview
expression in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method
-
expression of the His-tagged carboxyltransferase domain comprising residues 1548-2346 in Escherichia coli
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
human cytomegalovirus infection activates ACC1 expression about 3fold 72 h post infection, increasing the abundance of both ACC1 mRNA and protein. Viral gene expression but not viral DANN replication is necessary for human cytomegalovirus-mediated induction of ACC1 levels
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
synthesis
expression in Bombyx mori using the silkworm NPV bacmid system. Recombinant protein shows biotinylation capacity,and exhibits posttranslational biotinylation and phosphorylation
drug development
-
the enzyme is a target for drug development in case of obesity, diabetes, and other symptoms of the metabolic syndrome
drug development
-
inhibition of ACC demonstrates promising therapeutic potential for treating obesity and type 2 diabetes mellitus in transgenic mice and preclinical animal models
drug development
-
the enzyme is a target for drug development in treatment of obesity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brownsey, R.W.; Zhande, R.; Boone, A.N.
Isoforms of acetyl-CoA carboxylase: structures, regulatory properties and metabolic functions
Biochem. Soc. Trans.
25
1232-1238
1997
Anabaena sp., Metazoa, Cyclotella cryptica, Escherichia coli, Homo sapiens, Mammalia, Pseudomonas sp.
Abu-Elheiga, L.; Almarza-Ortega, D.B.; Baldini, A.; Wakil, S.J.
Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms
J. Biol. Chem.
272
10669-10677
1997
Homo sapiens (O00763), Homo sapiens
Abu-Elheiga, L.; Jayakumar, A.; Baldini, A.; Chirala, S.S.; Wakil, S.J.
Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms
Proc. Natl. Acad. Sci. USA
25
4011-4015
1995
Homo sapiens
Travers, M.T.; Vallance, A.J.; Clegg, R.A.; Thomson, R.; Price, N.T.; Barber, M.C.
Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects
Biochim. Biophys. Acta
1634
97-106
2003
Homo sapiens (Q13085), Homo sapiens
Baez-Saldana, A.; Zendejas-Ruiz, I.; Revilla-Monsalve, C.; Islas-Andrade, S.; Cardenas, A.; Rojas-Ochoa, A.; Vilches, A.; Fernandez-Mejia, C.
Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects
Am. J. Clin. Nutr.
79
238-243
2004
Homo sapiens
Vlasova, T.I.; Stratton, S.L.; Wells, A.M.; Mock, N.I.; Mock, D.M.
Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood
J. Nutr.
135
42-47
2005
Homo sapiens (O00763), Homo sapiens
Barber, M.C.; Price, N.T.; Travers, M.T.
Structure and regulation of acetyl-CoA carboxylase genes of metazoa
Biochim. Biophys. Acta
1733
1-28
2005
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis briggsae, Caenorhabditis elegans, Gallus gallus, Ciona intestinalis, Drosophila melanogaster, Escherichia coli, Ovis aries, Takifugu rubripes, Homo sapiens (O00763), Homo sapiens (Q13085), Rattus norvegicus (O70151), Rattus norvegicus (P11497), Mus musculus (Q5SWU9), Mus musculus (Q6JIZ0), Caenorhabditis elegans W09B6
Tong, L.
Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
Cell. Mol. Life Sci.
62
1784-1803
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Hordeum vulgare, Mus musculus, Oryza sativa, Rattus norvegicus, Schizosaccharomyces pombe, Streptomyces coelicolor, Toxoplasma gondii
Zhang, H.; Tweel, B.; Li, J.; Tong, L.
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186
Structure
12
1683-1691
2004
Saccharomyces cerevisiae, Homo sapiens
Brownsey, R.W.; Boone, A.N.; Elliott, J.E.; Kulpa, J.E.; Lee, W.M.
Regulation of acetyl-CoA carboxylase
Biochem. Soc. Trans.
34
223-227
2006
Rattus norvegicus, Homo sapiens (Q13085)
Clark, R.F.; Zhang, T.; Xin, Z.; Liu, G.; Wang, Y.; Hansen, T.M.; Wang, X.; Wang, R.; Zhang, X.; Frevert, E.U.; Camp, H.S.; Beutel, B.A.; Sham, H.L.; Gu, Y.G.
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity
Bioorg. Med. Chem. Lett.
16
6078-6081
2006
Homo sapiens
Clark, R.F.; Zhang, T.; Wang, X.; Wang, R.; Zhang, X.; Camp, H.S.; Beutel, B.A.; Sham, H.L.; Gu, Y.G.
Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents
Bioorg. Med. Chem. Lett.
17
1961-1965
2007
Homo sapiens
Chajes, V.; Cambot, M.; Moreau, K.; Lenoir, G.M.; Joulin, V.
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival
Cancer Res.
66
5287-5294
2006
Homo sapiens (Q13085), Homo sapiens
Tong, L.; Harwood, H.J.
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery
J. Cell. Biochem.
99
1476-1488
2006
Homo sapiens (O00763), Homo sapiens (Q13085)
Brunet, J.; Vazquez-Martin, A.; Colomer, R.; Grana-Suarez, B.; Martin-Castillo, B.; Menendez, J.A.
BRCA1 and acetyl-CoA carboxylase: The metabolic syndrome of breast cancer
Mol. Carcinog.
47
157-163
2008
Homo sapiens (Q13085), Homo sapiens
Cheng, D.; Chu, C.H.; Chen, L.; Feder, J.N.; Mintier, G.A.; Wu, Y.; Cook, J.W.; Harpel, M.R.; Locke, G.A.; An, Y.; Tamura, J.K.
Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes
Protein Expr. Purif.
51
11-21
2007
Rattus norvegicus, Homo sapiens (O00763), Homo sapiens (Q13085), Homo sapiens
Kim, K.W.; Yamane, H.; Zondlo, J.; Busby, J.; Wang, M.
Expression, purification, and characterization of human acetyl-CoA carboxylase 2
Protein Expr. Purif.
53
16-23
2007
Homo sapiens (O00763), Homo sapiens
Ray, H.; Suau, F.; Vincent, A.; Dalla Venezia, N.
Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex
Biochem. Biophys. Res. Commun.
378
615-619
2009
Homo sapiens
Cao, C.; Lu, S.; Kivlin, R.; Wallin, B.; Card, E.; Bagdasarian, A.; Tamakloe, T.; Chu, W.M.; Guan, K.L.; Wan, Y.
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes
J. Biol. Chem.
283
28897-28908
2008
Homo sapiens
Swierczynski, J.; Goyke, E.; Korczynska, J.; Jankowski, Z.
Acetyl-CoA carboxylase and fatty acid synthase activities in human hypothalamus
Neurosci. Lett.
444
209-211
2008
Homo sapiens
Kaushik, V.K.; Kavana, M.; Volz, J.M.; Weldon, S.C.; Hanrahan, S.; Xu, J.; Caplan, S.L.; Hubbard, B.K.
Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics
Biochim. Biophys. Acta
1794
961-967
2009
Homo sapiens
Raymer, B.; Kavana, M.; Price, A.; Wang, B.; Corcoran, L.; Kulathila, R.; Groarke, J.; Mann, T.
Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase
Bioorg. Med. Chem. Lett.
19
2804-2807
2009
Homo sapiens (O00763)
Haque, T.S.; Liang, N.; Golla, R.; Seethala, R.; Ma, Z.; Ewing, W.R.; Cooper, C.B.; Pelleymounter, M.A.; Poss, M.A.; Cheng, D.
Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase
Bioorg. Med. Chem. Lett.
19
5872-5876
2009
Homo sapiens
Chonan, T.; Oi, T.; Yamamoto, D.; Yashiro, M.; Wakasugi, D.; Tanaka, H.; Ohoka-Sugita, A.; Io, F.; Koretsune, H.; Hiratate, A.
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors
Bioorg. Med. Chem. Lett.
19
6645-6648
2009
Homo sapiens
Corbett, J.W.; Freeman-Cook, K.D.; Elliott, R.; Vajdos, F.; Rajamohan, F.; Kohls, D.; Marr, E.; Zhang, H.; Tong, L.; Tu, M.; Murdande, S.; Doran, S.D.; Houser, J.A.; Song, W.; Jones, C.J.; Coffey, S.B.; Buzon, L.; Minich, M.L.; Dirico, K.J.; Tapley, S.; McPherson, R.K.; Sugarman, E.; Harwood, H.J.; Esler, W.
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2
Bioorg. Med. Chem. Lett.
20
2383-2388
2010
Homo sapiens, Rattus norvegicus
Chen, C.H.; Chang, M.Y.; Lin, Y.S.; Lin, D.G.; Chen, S.W.; Chao, P.M.
A herbal extract with acetyl-coenzyme A carboxylase inhibitory activity and its potential for treating metabolic syndrome
Metab. Clin. Exp.
58
1297-1305
2009
Homo sapiens, Mus musculus, Rattus norvegicus, Mus musculus C57/BL6J
Scaglia, N.; Chisholm, J.W.; Igal, R.A.
Inhibition of stearoyl-CoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK
PLoS ONE
4
e6812
2009
Homo sapiens
Chonan, T.; Tanaka, H.; Yamamoto, D.; Yashiro, M.; Oi, T.; Wakasugi, D.; Ohoka-Sugita, A.; Io, F.; Koretsune, H.; Hiratate, A.
Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors
Bioorg. Med. Chem. Lett.
20
3965-3968
2010
Homo sapiens
Chonan, T.; Wakasugi, D.; Yamamoto, D.; Yashiro, M.; Oi, T.; Tanaka, H.; Ohoka-Sugita, A.; Io, F.; Koretsune, H.; Hiratate, A.
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group
Bioorg. Med. Chem.
19
1580-1593
2011
Homo sapiens
Bengtsson, C.; Blaho, S.; Saitton, D.B.; Brickmann, K.; Broddefalk, J.; Davidsson, O.; Drmota, T.; Folmer, R.; Hallberg, K.; Hallen, S.; et al.
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats
Bioorg. Med. Chem.
19
3039-3053
2011
Homo sapiens, Rattus norvegicus
Keil, S.; Mueller, M.; Zoller, G.; Haschke, G.; Schroeter, K.; Glien, M.; Ruf, S.; Focken, I.; Herling, A.W.; Schmoll, D.
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation
J. Med. Chem.
53
8679-8687
2010
Homo sapiens, Rattus norvegicus
Spencer, C.M.; Schafer, X.L.; Moorman, N.J.; Munger, J.
Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication
J. Virol.
85
5814-5824
2011
Homo sapiens
Kamata, M.; Yamashita, T.; Kina, A.; Funata, M.; Mizukami, A.; Sasaki, M.; Tani, A.; Funami, M.; Amano, N.; Fukatsu, K.
Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors
Bioorg. Med. Chem. Lett.
22
3643-3647
2012
Homo sapiens (O00763), Homo sapiens (Q13085), Homo sapiens
Kamata, M.; Yamashita, T.; Kina, A.; Tawada, M.; Endo, S.; Mizukami, A.; Sasaki, M.; Tani, A.; Nakano, Y.; Watanabe, Y.; Furuyama, N.; Funami, M.; Amano, N.; Fukatsu, K.
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
Bioorg. Med. Chem. Lett.
22
4769-4772
2012
Homo sapiens (O00763), Homo sapiens (Q13085)
Bourbeau, M.P.; Siegmund, A.; Allen, J.G.; Shu, H.; Fotsch, C.; Bartberger, M.D.; Kim, K.W.; Komorowski, R.; Graham, M.; Busby, J.; Wang, M.; Meyer, J.; Xu, Y.; Salyers, K.; Fielden, M.; Veniant, M.M.; Gu, W.
Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase
J. Med. Chem.
56
10132-10141
2013
Homo sapiens, Homo sapiens (Q13085)
Hwang, I.W.; Makishima, Y.; Kato, T.; Park, S.; Terzic, A.; Park, E.Y.
Human acetyl-CoA carboxylase 2 expressed in silkworm Bombyx mori exhibits posttranslational biotinylation and phosphorylation
Appl. Microbiol. Biotechnol.
98
8201-8209
2014
Homo sapiens (O00763), Homo sapiens
Monteuuis, G.; Suomi, F.; Keraetaer, J.M.; Masud, A.J.; Kastaniotis, A.J.
A conserved mammalian mitochondrial isoform of acetyl-CoA carboxylase ACC1 provides the malonyl-CoA essential for mitochondrial biogenesis in tandem with ACSF3
Biochem. J.
474
3783-3797
2017
Homo sapiens (Q13085), Homo sapiens, Mus musculus (Q5SWU9), Mus musculus
Glatzel, D.K.; Koeberle, A.; Pein, H.; Loeser, K.; Stark, A.; Keksel, N.; Werz, O.; Mueller, R.; Bischoff, I.; Fuerst, R.
Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition
J. Lipid Res.
59
298-311
2018
Homo sapiens (Q13085), Homo sapiens
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