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Information on EC 6.4.1.2 - acetyl-CoA carboxylase
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6.4.1.2 acetyl-CoA carboxylaseIUBMB Comments
This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
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Word Map
- 6.4.1.2
-
amp-activated
- triglyceride
-
lipogenesis
- adipose
-
lipogenic
- sterol
- peroxisome
- cholesterol
- obesity
- carnitine
- malonyl-coa
-
proliferator-activated
-
high-fat
- adipocytes
- lipoprotein
-
element-binding
- biotin
- steatosis
- lipase
-
obese
-
herbicide
- srebp-1c
- triacylglycerols
-
diet-induced
- stearoyl-coa
-
malic
- adiponectin
- nafld
-
lipolysis
-
monophosphate-activated
-
hfd-induced
- protein-1c
-
weed
- carboxylases
- aicar
-
atp-citrate
-
malonyl
-
desaturase-1
-
anti-obesity
-
biotin-dependent
-
hormone-sensitive
-
chrebp
-
5'-amp-activated
-
palmitoyltransferase-1
-
target-site
- adenoid
-
srebf1
-
anti-adipogenic
- lolium
- biotechnology
- medicine
-
herbicide-resistant
- pharmacology
- synthesis
- drug development
- biofuel production
- agriculture
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
acetyl-coa carboxylase, accase, acetyl coa carboxylase, acetyl-coenzyme a carboxylase, acaca, acc-2, acetyl coenzyme a carboxylase, acetyl-coa carboxylase 1, acc-1, acacb, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ACACA
ACC
ACC1
Acc1p
ACC2
AccA
ACCase
ACCB
Acetyl CoA carboxylase
Acetyl coenzyme A carboxylase
-
-
-
-
acetyl-CoA carboxylase
acetyl-CoA carboxylase 1
acetyl-CoA carboxylase 2
acetyl-CoA/propionyl-CoA carboxylase
Acetyl-coenzyme A carboxylase
BCCP1
BCCP2
Carboxylase, acetyl coenzyme A
-
-
-
-
Hfa1p
additional information
ACC
-
structural organization of the ACC multienzyme into distinct biotinoyl carboxyl carrier protein, biotin carboxylase, and carboxyltransferase components
ACC
-
structural organization of the ACC multienzyme into distinct biotinoyl carboxyl carrier protein, biotin carboxylase, and carboxyltransferase components
ACCase
-
-
-
-
ACCase
-
ACCase
-
the ACCase that preferentially accepts acetyl-CoA as a substrate is defined as an acetyl-CoA carboxylase (ACC)
Acetyl CoA carboxylase
-
-
-
-
acetyl-CoA/propionyl-CoA carboxylase
-
enzyme acts on both substrates
acetyl-CoA/propionyl-CoA carboxylase
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
enzyme acts on both substrates
-
acetyl-CoA/propionyl-CoA carboxylase
enzyme acts on both substrates
acetyl-CoA/propionyl-CoA carboxylase
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
enzyme acts on both substrates
-
acetyl-CoA/propionyl-CoA carboxylase
-
enzyme acts on both substrates
Acetyl-coenzyme A carboxylase
-
-
-
-
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
-
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
Q6JIZ0
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
non-ordered ter ter mechanism
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
ordered bi bi uni uni ping-pong mechanism
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
ordered mechanism
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
molecular surface of the active site of the carboxyltransferase domain
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
substrate specificity, catalytic mechanism, and structural features
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme proceeds through a hybrid (two-site) random Ter Ter mechanism, one that likely involves a two-step reaction at the biotin carboxylase domain
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
-
-
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
carboxylation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:hydrogencarbonate ligase (ADP-forming)
This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
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CAS REGISTRY NUMBER
COMMENTARY
9023-93-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + biotin + HCO3-
ADP + ? + phosphate
-
free biotin can be used as carboxyl acceptor with low activity
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + methylmalonyl-CoA + phosphate
-
-
-
-
r
n-butyryl-CoA + HCO3-
?
Q877I4; Q877I5; Q877I3
4.6% activity compared to acetyl-CoA or propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
?
Q877I4; Q877I3; Q877I5
n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA, which is used as the substrate in the biosynthesis of a variety of polyketide derivatives, including fatty acids, flavonoids, and stilbenoids. In addition malonyl-CoA is used as the substrate for the malonation of a variety of plant phytochemicals
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
first committed step in biosynthesis of fatty acids, providing the essential substrate for fatty acid synthetase
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
catalyzes the first committed step in the synthesis of fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
key enzyme of de nove fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA which is required for plastid localized fatty acid biosynthesis and for a variety of pathways in the cytoplasm including flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
hormonal, nutrient, and tissue-specific regulation of ACC genes, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
Q5SWU9, Q6JIZ0
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
Q5SWU9, Q6JIZ0
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by pH, redox, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme is essential for viability
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme activity is limiting for lipid synthesis in tubers, biosynthetic pathway and regulatory aspects, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme activity is involved in biosynthesis of fatty acids as well as polyketids, which are precursors of pharmaceutically important antibiotics, anticancer agents and other drugs
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
wild-type enzyme, transcarboxylation between biotin and acetyl-CoA is catalyzed by the core catalytic beta-subunit
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the enzyme catalyzes the first step in fatty acid bioynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Q877I4; Q877I3; Q877I5
the bifunctional enzyme also catalyzes the carboxylation of propionyl-CoA. Vmax/Km for carboxylation of propanoyl-CoA is 1.6fold higher than Vmax/Km for carboxylation of acetyl-CoA. Quite specific for ATP. No activity with ADP, AMP, GTP, CTP, UTP, or dTTP (0.2 mM)
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Acidianus infernus So4a / DSM 3191
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
ACC catalyzes the first committed step in the synthesis of long-chain fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
absolute specificity for acetyl-CoA
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
ACC plays an important role in energy balance by controlling malonyl-CoA synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
15% of the activity relative to acetyl-CoA
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
60% of the activity relative to acetyl-CoA
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
-
-
-
r
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
-
wild-type enzyme
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
10% of the activity relative to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
no activity
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
acetyl-CoA carboxylase and propionyl-CoA carboxylase are different enzymes
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
no activity
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
second activity of the protein representing EC 6.4.1.3
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
second activity of the protein representing EC 6.4.1.3
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
60% of the activity relative to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
maximal rate is 20% of that for acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
maximal rate is 20% of that for acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
13% of the activity relative to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
45% of the activity compared to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
highly preferred substrate
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
wild-type and mutant I420D enzyme
-
-
?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
10% of the activity obtained with ATP
-
?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
10% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
40% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
40% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
-
at 2.5% of the activity relative to ATP
-
-
?
additional information
?
-
Q877I4; Q877I3; Q877I5
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
Q877I4; Q877I5; Q877I3
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
ACCase 1 is essential for correct plant development
-
-
?
additional information
?
-
-
acetyl-CoA carboxylase is a multifunctional biotin-dependent enzyme that catalyzes the first committed and regulated step in fatty acid biosynthesis in bacteria via a two-step reaction. Biotin carboxylase, EC 6.3.4.14, catalyzes the first half-reaction, which is an ATP-dependent carboxylation of biotin to form carboxybiotin. The second half-reaction is catalyzed by carboxyltransferase, EC 6.4.1.2, which transfers the carboxyl group from carboxybiotin to acetyl-CoA to generate malonyl-CoA
-
-
?
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
?
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
?
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
?
additional information
?
-
-
isozymes ACC1 and ACC2 play roles in lipid metabolism in adipose tissue, overview
-
-
?
additional information
?
-
-
perinatal copper deficiency in rat pups inhibits the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
?
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA, which is used as the substrate in the biosynthesis of a variety of polyketide derivatives, including fatty acids, flavonoids, and stilbenoids. In addition malonyl-CoA is used as the substrate for the malonation of a variety of plant phytochemicals
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
first committed step in biosynthesis of fatty acids, providing the essential substrate for fatty acid synthetase
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
catalyzes the first committed step in the synthesis of fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
key enzyme of de nove fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA which is required for plastid localized fatty acid biosynthesis and for a variety of pathways in the cytoplasm including flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
hormonal, nutrient, and tissue-specific regulation of ACC genes, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
Q5SWU9, Q6JIZ0
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by pH, redox, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme is essential for viability
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme activity is limiting for lipid synthesis in tubers, biosynthetic pathway and regulatory aspects, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme activity is involved in biosynthesis of fatty acids as well as polyketids, which are precursors of pharmaceutically important antibiotics, anticancer agents and other drugs
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the enzyme catalyzes the first step in fatty acid bioynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Acidianus infernus So4a / DSM 3191
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
ACC catalyzes the first committed step in the synthesis of long-chain fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
ACC plays an important role in energy balance by controlling malonyl-CoA synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
additional information
?
-
ACCase 1 is essential for correct plant development
-
-
?
additional information
?
-
-
acetyl-CoA carboxylase is a multifunctional biotin-dependent enzyme that catalyzes the first committed and regulated step in fatty acid biosynthesis in bacteria via a two-step reaction. Biotin carboxylase, EC 6.3.4.14, catalyzes the first half-reaction, which is an ATP-dependent carboxylation of biotin to form carboxybiotin. The second half-reaction is catalyzed by carboxyltransferase, EC 6.4.1.2, which transfers the carboxyl group from carboxybiotin to acetyl-CoA to generate malonyl-CoA
-
-
?
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
?
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
?
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
?
additional information
?
-
-
isozymes ACC1 and ACC2 play roles in lipid metabolism in adipose tissue, overview
-
-
?
additional information
?
-
-
perinatal copper deficiency in rat pups inhibits the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
?
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ATP
-
-
660652, 664564, 666936, 672610, 672618, 694384, 702459, 702599, 705505, 714411, 714460, 714466, 716068
ATP
-
ATP
Q877I4; Q877I5; Q877I3
the enzyme exhibits the maximum activity when the ATP concentration is 1.0-1.5 mM. Neither ADP, AMP, GTP, CTP, UTP, nor dTTP (0.2 mM) can substitute for ATP
biotin
-
conformational change accompanies biotinylation of the biotin domain
biotin
-
transcarboxylation between biotin and acetyl-CoA catalyzed by the core catalytic beta-subunit
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Cs+
K+
Mg2+
Mn2+
NH4+
phosphate
additional information
Co2+
Q877I4; Q877I3; Q877I5
26% of the maximum activity is observed when Co2+ (10 to 15 mM) is used as a divalent cation
Cs+
-
small activating effect, depends on the degree of saturation of the reaction by HCO3-
K+
-
small activating effect, depends on the degree of saturation of the reaction by HCO3-
K+
-
greatest activation at 12-15 mM K+, at HCO3- concentration of 0.18 mM, 1 mM, and 10 mM
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
optimal concentration of 9686 enzyme: 5 mM, optimal concentration of Wayne enzyme: 3 mM
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
concentration of Mg2+ must be sufficient to allow chelation by both ATP and citrate. Free Mg2+ inhibits
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
maximal activation when ATP exists largely as MgATP2- with low concentrations of free Mg2+
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mg2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
Q877I4; Q877I3; Q877I5
1.0 mM Mn2+ gives 82% of the maximum activity obtained with the Mg2+ ion
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
Mn2+ or Mg2+ essential for activity. Maximal activation at 1.5 mM Mn2+
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
the enzyme requires Mg2+ or Mn2+ for coordinating the ATP phosphates for catalysis
Mn2+
-
maximal activity at 1 mM Mn2+ with 1 mM ATP. Maximal activity is 25% of that observed with Mg2+
phosphate
-
phosphate content of the 10000000 MW enzyme form: 4.0 mol of phosphate per mol of subunit. Phosphate content of the 2000000 MW enzyme form: 6.0 mol phosphate per mol of subunit. The 10000000 MW subunit and the 2000000 MW subunit are interconvertible by phosphorylation and dephosphorylation. Dephosphorylation by [acetyl-CoA carboxylase]-phosphatase 2 activates the enzyme and reduces its dependence on citrate
phosphate
-
contains approximately 6 mol phosphate per 240000 g of protein
additional information
Q877I4; Q877I5; Q877I3
Fe2+, Cu2+, Ca2+, and Ni2+ (0.5 to 20 mM) have no effect on enzyme activity
additional information
-
Fe2+, Cu2+, Ca2+, and Ni2+ (0.5 to 20 mM) have no effect on enzyme activity
additional information
-
the zinc domain in bacterial carboxyltransferase belongs to the zinc ribbon class of zinc fingers, Zn domains are commonly associated with DNA binding
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(+)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]methoxybenzoic acid
-
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
-
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
-
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
-
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
-
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-6-morpholin-4-yl-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
7% inhibition at 0.01 mM
1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
16% inhibition at 0.01 mM
1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
51% inhibition at 0.005 mM
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
-
i.e. CP-640186 or bispiperidylcarboxamide derivative I with a tricyclic hydrophobic core, shows inhibition of both ACC1 and ACC2
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
44% inhibition at 0.01 mM
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-(1H-1,2,4-triazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
complete inhibition at 0.005 mM
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-[(1-methyl-1H-pyrazol-5-yl)amino]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
complete inhibition at 0.005 mM
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1,1,1-trifluoro-2-methylpropan-2-yl 4-(4-[[2-amino-6-(trifluoromethyl)-1-benzothiophen-3-yl]carbonyl]piperazin-1-yl)piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
selective and potent ACC1 inhibitor, shows acceptable solubility and CYP inhibition profiles. Oral administration significantly reduces the concentration of malonyl-CoA in HCT-116 xenograft tumors at doses of more than 30 mg/kg
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
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1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
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1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
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1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
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1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
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1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
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1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
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1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
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1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
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1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
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1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
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1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
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1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
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1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
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1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
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1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
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1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
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1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
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1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
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1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
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1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
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1-ethyl-3-[3-[(4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1-benzothiophen-2-yl]urea
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1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
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1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
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1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
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1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
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1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
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1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
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1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
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1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
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1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
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1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
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1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
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1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
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1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
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1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
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1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
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1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
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1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
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2'-tert-butyl-1-(1H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one
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2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]-methyl)cyclohexyl]methyl]carbamate
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2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
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2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
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2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
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3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
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4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
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4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
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4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
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4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
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5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
5-[1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]pyridine-3-carboxylic acid
-
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
6-morpholin-4-yl-1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
64% inhibition at 0.01 mM
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
Acyl carrier protein
-
acylated derivatives, acyls with chain lengths from C6:0 to C20:1 are inhibitory, 0.04 mM results in 60-70% inhibition, complete inhibition not achieved even with very high concentrations
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
beta,beta'-Tetramethyl-substituted hexadecanedioic acid
-
i.e. MEDICA, dead-end inhibitor
BODIPY-soraphen A
a soraphen A derivative, shows high activity against ACC2, synthesis, overview. BODIPY-soraphen A directly binds to the BC domain of the ACC enzyme by causing a 10°C increase in thermal stability of the protein using a differential scanning calorimetry assay
BRCA1 protein
-
BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction
-
CoASH
Q877I4; Q877I5; Q877I3
inhibits acetyl-CoA carboxylase activity 50 to 57% and propionyl-CoA carboxylase activity 11 to 13%
coenzyme A-carboxybiotin
-
coenzyme A is covalently attached to carboxybiotin, bisubstrate inhibitor
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
dithiothreitol
Q877I4; Q877I5; Q877I3
dithiothreitol inhibits the enzyme slightly, by approximately 12%, at a final concentration of 5 to 10 mM
Double-stranded DNA
-
inhibits catalysis by the carboxyltransferase subunit of acetyl-CoA carboxylase by complex formation and influencing the active site structure, while substrates malonyl-CoA and biocytin inhibit DNA-carboxyltransferase complex formation, overview. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclo-hexyl]-methyl]carbamate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
H2O2
-
dark enzyme completely inhibited at 2 mM, slight activity observed with light enzyme
heparin
-
the DNA mimic inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
High molecular weight protein
-
from rat liver cytosol, approximately 1500000-2000000 Da
-
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
-
-
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
-
-
N-(1-(2,2'-dimethyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)-1H-pyrazole-4-carboxamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)cyclopropanecarboxamide
-
-
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
-
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
-
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-(2-chloro-4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
-
moderate selective isoform ACC2 inhibitor
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
-
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
-
-
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
-
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
-
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
-
-
N-[1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
4% inhibition at 0.01 mM
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-N-methylbutanamide
-
83% inhibition at 0.01 mM
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide
-
-
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
-
-
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[4-oxo-1'-(10H-phenothiazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
48% inhibition at 0.01 mM
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
-
palmitoyl-acyl carrier protein
5 min, 55% inhibition, decrease of inhibition thereafter. Enzyme exhibits a significant hysteresis in presence of palmitoyl-acyl carrier protein. Allosteric inhibitor, the pantothenic acid moiety of palmitoyl-acyl carrier protein is responsible for the inhibition. Competitive with respect to acetyl-CoA
-
PII protein
-
recombinant Arabidopsis PII protein inhibits chloroplastic ACCase activity dose-dependently and noncompetitively via binding to its BCCP subunit, and this is completely reversed in the presence of 2-oxoglutarate, pyruvate, or oxaloacetate. PII protein decreases the Vmax of the ACCase reaction without altering the Km for acetyl-CoA
-
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
propionyl-CoA
-
below 0.1 mM almost as effective as substrate as acetyl-CoA, inhibitory at higher concentrations
single-stranded DNA
-
inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
tepraloxydim
a herbicide, binding mode and structure-activity relationship, molecular inhibition mechanism, overview
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
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-
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
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-
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
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tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]-methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)methyl]-carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]-carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)-methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]-cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclo-hexyl]methyl]carbamate acetate
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]-methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]-methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]-methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
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(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
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(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
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-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
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(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
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(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
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-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
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(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM, for the wild-type enzyme in crude extract 11 nM
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
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-
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM, for the wild-type enzyme in crude extract 288 nM
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
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1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
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1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
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1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
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-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
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1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
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-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5-(tetradecyloxy)-2-furoic acid
an ACC1 inhibitor e.g. in beta cells
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM, for the wild-type enzyme in crude extract 8 nM
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
i.e. CP-640186
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
-
ATP
Q877I4; Q877I5; Q877I3
an excess of ATP (2.0 mM) has an inhibitory effect on the enzymatic activities
citrate
Q877I4; Q877I5; Q877I3
citrate inhibits the enzyme activity by more than 50% at concentrations of 3 mM
citrate
-
9686 enzyme: below 3 mM no effect, inhibition above. Wayne enzyme: slight stimulation up to 5 mM, strong inhibition above
Clethodim
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Clodinafop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Clodinafop
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
CoA
-
inhibition requires the presence of MgATP2-, but is independent of phosphorylation of the enzyme, the effect is complete in about 5 min and is associated with depolymerization of acetyl-CoA carboxylase, half-maximal inhibition at 0.04 mM CoA, inhibition is partially reversed by incubation with citrate and more fully overcome by treatment of the enzyme with the insulin-stimulated acetyl-CoA carboxylase
CP-640186
-
inhibition of both isozymes Acc1 and Acc2, an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
herbicide, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure, binds to the biotin binding site
CP-640186
-
an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site
Cycloxydim
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Diclofop
-
Diclofop
herbicide, molecular inhibition mechanism, active site binding structure involving Tyr1738 and Phe1956, binding induces large conformational changes in the enzyme
fenoxaprop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
fenoxaprop
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
fenoxaprop
-
a specific inhibitor of the cytosolic ACCase, does not affect the activity of chloroplast ACCase
Fluazifop
-
Haloxyfop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Haloxyfop
-
Haloxyfop
herbicide, molecular inhibition mechanism, active site binding structure involving Tyr1738 and Phe1956, binding induces large conformational changes in the enzyme
Haloxyfop
-
herbicide, binding structure and inhibition mechanism, binds to an allosteric site
Haloxyfop
-
0.001 mM, 65-80% inhibition of acetyl-CoA carboxylase I, less than 50% inhibition of acetyl-CoA carboxylase II
K+
Q877I4; Q877I5; Q877I3
the enzyme shows less than 50% activity when the concentration is higher than 40 mM
malonyl-CoA
Q877I4; Q877I5; Q877I3
inhibits acetyl-CoA carboxylase activity 50 to 57% and propionyl-CoA carboxylase activity 11 to 13%
malonyl-CoA
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
Q5SWU9, Q6JIZ0
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
Mg2+
Q877I4; Q877I5; Q877I3
an excess of Mg2+ (higher than 4.0 mM) has an inhibitory effect on the enzymatic activities
Mn2+
Q877I4; Q877I5; Q877I3
an excess of Mn2+ (higher than 2.0 mM) has an inhibitory effect on the enzymatic activities
moiramide B
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, competitive with respect to malonyl-CoA, noncompetitive to biocytin, IC50 for the purified recombinant subunits AccA and AccD is 6 nM, for the wild-type enzyme in crude extract 15 nM
moiramide B
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 96 nM
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
potent and selective inhibitor
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
Na+
Q877I4; Q877I5; Q877I3
the enzyme shows less than 50% activity when the concentration is higher than 40 mM
pinoxaden
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
Quizalofop
-
seed enzyme which carboxylates acety-CoA and propionyl-CoA has two separate active sites. One site binds either acetyl-CoA or propionyl-CoA and is inhibited by quizalofop. The other site is specific for acetyl-CoA and is much less inhibited by quizalofop. The leaf enzyme is not able to carboxylate propionyl-CoA and is insensitive to quizalofop
Quizalofop
-
ACCase2 isoform is about 1/2000 as sensitive as ACCase1 isoform. Mixed-type inhibition of ACCase1 isoform with respect to acetyl-CoA or ATP
Quizalofop
-
mesophyll chloroplast isoform reveals 1000fold greater sensitivity than non-mesophyll chloroplast isoform
Sethoxydim
-
Sethoxydim
-
0.01 mM, 65-80% inhibition of acetyl-CoA carboxylase I, less than 50% inhibition of acetyl-CoA carboxylase II
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
inhibitor reduces the levels of malonyl-CoA in endothelial cells
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
natural macrocyclic polyketid, inhibition mechanism, the inhibitor binds to an allosteric site in vicinity to the active site at the biotin carboxylase domain dimer interface causing only small coformational changes, binding structure and specificity
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
inhibits the enzyme allosterically by stabilizing a catalytically inactive conformation of the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
sulfate
Q877I4; Q877I5; Q877I3
sulfate inhibits the enzyme activity by more than 50% at concentrations of 25 mM
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tralkoxydim
-
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
-
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
subunit AccB is a negative autoregulator of the accBC operon, overview
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, overview, FOP herbicides are weak inhibitors of the human enzyme
-
additional information
-
product inhibition analysis, inhibition patterns, overview
-
additional information
-
synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases containing biphenyl or 3-phenyl pyridine cores
-
additional information
-
disubstituted (4-piperidinyl)-piperazine derivatives act as ACC1/2 non-selective inhibitors
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, effectively reduces ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells, overview
-
additional information
-
inhibition of stearoyl-CoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells, overview
-
additional information
-
cereal crops are resistant to FOP herbicides, overview
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, FOP herbicides are weak inhibitors of the murine enzyme
-
additional information
-
synthesis of spiro[chroman-2,4-piperidin]-4-one derivatives as ACC inhibitors, overview
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview
-
additional information
-
cereal crops are resistant to FOÜ herbicides, overview
-
additional information
-
3,3,14,14-tetramethylhexanedecadienoic acid treatment if animals inhibits activity in liver by activation of AMP-activated protein kinase, no effect in muscle
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, FOP herbicides are weak inhibitors of the rat enzyme
-
additional information
-
no inhibition of the rat enzyme by pyrrolidine dione moiramide B, i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, and its derivatve 6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
additional information
-
activated AMP-activated protein kinase, AMPK, phosphorylates and inhibits acetyl-CoA carboxylase. ACC is inhibited in Cu-deficient cerebella
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC in liver microsomes with IC50 = 0.03 mg/ml. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview
-
additional information
-
FOP herbicides are weak inhibitors of the yeast enzyme
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
no inhibition with Clethodim, Sethoxydim and Cethoxydim
-
additional information
-
no inhibition with Clethodim, Sethoxydim and Cethoxydim
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
dithiothreitol
-
light enzyme is activated 2fold, dark enzyme is activated 6fold, carboxyltransferase but not biotin carboxylase reaction found to be redox regulated
biotin
-
required for subunit AccB activity, biotin is not involved in regulation of operon accBC transcription
citrate
-
maximal stimulation of 25%, significant activity in absence of citrate
citrate
-
activates both by increasing kcat and kcat/KM for ATP and acetyl-CoA, has a putative regulatory function on ACC2
citrate
allosteric activation, presence of citrate leads to dose-dependent formation of dimers and tetramers
citrate
-
completely inactive in absence of the allosteric activator citrate
citrate
-
nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate
citrate
-
completely inactive in absence of the allosteric activator citrate
citrate
-
an intermediate metabolite, activates hypothalamic ACC and is involved in the control of energy mobilization
citrate
-
up to 1 mM no effect on isoform ACCase I activity, inhibitory above. 0.25-10 mM stimulates isoform ACCase 2 activity
glutamate
-
role as physiological activator postulated, 4fold activation in absence of citrate, affects phosphorylation of enzyme
isocitrate
-
nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate
palmitoyl-CoA
Q877I4; Q877I3; Q877I5
slight stimulative effect on acetyl-CoA carboxylase (116%) and propionyl-CoA carboxylase (135%)
palmitoyl-CoA
Q877I4; Q877I5; Q877I3
0.5 mM palmitoyl-CoA has a slight stimulative effect on acetyl-CoA carboxylase (116%) and propionyl-CoA carboxylase (135%) activities
additional information
Q877I4; Q877I5; Q877I3
NADP+, NADPH, 3-hydroxypropionate, succinate, fumarate, malate, and glyoxylate have no significant effect on acetyl-CoA carboxylase or propionyl-CoA carboxylase activities
-
additional information
-
NADP+, NADPH, 3-hydroxypropionate, succinate, fumarate, malate, and glyoxylate have no significant effect on acetyl-CoA carboxylase or propionyl-CoA carboxylase activities
-
additional information
-
highest activity when fed a high carbohydrate, low fat diet
-
additional information
-
3,5,3'-triiodothyronine stimulates a 7fold increase in transcription in embryo hepatocytes cell culture
-
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
human cytomegalovirus infection also induces isoform ACC1's enzymatic activity
-
additional information
-
stevioside does not influence activity in the presence of 11.1 mM glucose
-
additional information
-
more than 200% increase in activity when rats were treated with troglitazone for 18 days
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0002
acetyl-CoA
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
0.01
acetyl-CoA
-
cytosolic enzyme from strain Rothamsted, pH 8.0, 30°C
0.1
acetyl-CoA
-
wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30°C
0.14
acetyl-CoA
-
plastidic enzyme from strain Rothamsted, pH 8.0, 30°C
0.052
ATP
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
0.053
ATP
wild-type, pH 7.5, temperature not specified in the publication
0.074
ATP
mutant Y83A, pH 7.5, temperature not specified in the publication
0.11
ATP
mutant Q608R, pH 7.5, temperature not specified in the publication
0.15
ATP
mutant R656E, pH 7.5, temperature not specified in the publication
0.099
butyryl-CoA
-
wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30°C
0.092
propionyl-CoA
-
wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30°C
additional information
additional information
-
Km-values in presence and absence of 5% polyethylene glycol 3350
-
additional information
additional information
-
effect of citrate or isocitrate on Km-values
-
additional information
additional information
-
effect of citrate or isocitrate on Km-values
-
additional information
additional information
kinetics of recombinant wild-type and mutant enzymes
-
additional information
additional information
-
kinetics of recombinant wild-type and mutant enzymes
-
additional information
additional information
-
kinetics of chimeric complexes of wild-type and mutant propionyl-CoA carboxylase, EC 6.4.1.3, subunits and acetyl-CoA carboxylase subunits
-
additional information
additional information
-
steady-state kinetic analysis of ACC2, kinetic mechanism, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.192
acetyl-CoA
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
0.155
ATP
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25°C
1.6
ATP
mutant Y83A, pH 7.5, temperature not specified in the publication
5
ATP
mutant R656E, pH 7.5, temperature not specified in the publication
8.5
ATP
wild-type, pH 7.5, temperature not specified in the publication
16
ATP
mutant Q608R, pH 7.5, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.088
palmitoyl-acyl carrier protein
pH 7.8, temperature not specified in the publication
-
additional information
additional information
-
dissociation constants of inhibitors CP-640186 and CP-640188
-
additional information
additional information
soraphen A dissociation constant is 0.8 nM
-
additional information
additional information
-
product inhibition kinetics, detailed overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00029
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000157
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000155
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000248
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000869
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000434
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000842
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.000178 - 0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.000789 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
0.000071 - 0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.00258 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
0.000273 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
0.00183 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
0.000246 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
0.000335 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
0.000486 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
0.000227 - 0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
0.000355 - 0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
0.000231 - 0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000244 - 0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000037 - 0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000258 - 0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000159 - 0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.00891
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
Rattus norvegicus
-
ACC1
0.00301
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
Rattus norvegicus
-
ACC1
0.00127
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
Rattus norvegicus
-
ACC1
0.000075
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000004 - 0.000091
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
0.000037 - 0.00054
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
0.001 - 0.00162
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
0.000163 - 0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.001 - 0.00132
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.000562
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000634 - 0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.00253
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00085
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00221
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000055
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
Mus musculus
-
ACC1 and ACC2
0.000006
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000014
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000027
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000002
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000026
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000036
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000061
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.0012
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000303
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
Rattus norvegicus
-
ACC1
0.0000061 - 0.000031
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000075
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0000045 - 0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000074
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019 - 0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000017 - 0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000076 - 0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000031
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000062
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000027
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000058 - 0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
0.000045
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000041
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000012
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000038
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00000058
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
Homo sapiens
pH 7.5, 22°C
0.00017 - 0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000022 - 0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000043 - 0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000048 - 0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00013 - 0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.0002 - 0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.0000049 - 0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
0.0000061 - 0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
0.0000059 - 0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
0.001864
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000242
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0000081 - 0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.000043 - 0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00002 - 0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000023 - 0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000014 - 0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000016 - 0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000027 - 0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
0.000049 - 0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000075 - 0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000184
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000052
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000068
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000076
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000102
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
Homo sapiens
-
ACC1/2
0.000169
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
Homo sapiens
-
ACC1/2
0.000126
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000115
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
Homo sapiens
-
ACC1/2
0.000076
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000127
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000069
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000057
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000032
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000037
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000021
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000055
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000059
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000169
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000061
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000049
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000036
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000048
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000105
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000166 - 0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
0.000391 - 0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000037 - 0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
0.000079 - 0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000207
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000597
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032 - 0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000033 - 0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000064 - 0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000051 - 0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000022 - 0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00004 - 0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000144
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000015 - 0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000009 - 0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000017
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000018 - 0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000012 - 0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.000249
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000766
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000045 - 0.00003
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.0000246
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000154
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000085 - 0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000013 - 0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
0.0000044 - 0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
0.000015 - 0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000109
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000081
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000049
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000017 - 0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000017 - 0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000074
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
ACC1/2
0.0001
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000072
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000027
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00007
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000084
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00338
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.001
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00013
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.038 - 0.054
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
0.0025 - 0.0057
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.000073
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.0035 - 0.017
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
0.000067
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.00075 - 0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
0.01
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000169
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000095
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000151
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.00008
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000023 - 0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.000061
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000086
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000034 - 0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.0011
5-(tetradecyloxy)-2-furoyl-CoA
Rattus norvegicus
-
pH 7.5, 37°C, partially purified native enzyme
0.0009 - 0.0046
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
0.0018 - 0.028
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000012 - 0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000019 - 0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000051 - 0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000065 - 0.000104
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000026
5-methoxy-1'-{[2-(pyridin-2-yl)-1H-benzimidazol-6-yl]carbonyl}spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016 - 0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
0.000011 - 0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
0.0035 - 0.0043
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.000054
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000097
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000975
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.00135
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000182
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000366
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000036
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000022 - 0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000236
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.0000064 - 0.000013
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.00183
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00139 - 0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000001 - 0.00005
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
0.000099
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000059
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000208
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.00006
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000325
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.000091
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000095
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000161
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000239
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000121
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.00007 - 0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.000076
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000244
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000052
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000055
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0014 - 0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.000102
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000175
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00025 - 0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.00162
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
Homo sapiens
-
isozyme ACC2
0.00616
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000018
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000009
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000014
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000013
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00021
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00013
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00038
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00029
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0000044 - 0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00007
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00001
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00081
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000057
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000067
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00037
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035 - 0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000054 - 0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
0.000036 - 0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
0.000348 - 0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
0.000061
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide
Mus musculus
-
-
0.001
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0158
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000035
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000069
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000012
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000029
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000034
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00014
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000042
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000011
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00026
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000026
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000005 - 0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000013
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000007
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00063 - 0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019 - 0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.000259 - 0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
0.000013
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000119
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00004 - 0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.000024 - 0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.03
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0078 - 0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00006 - 0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.0002 - 0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.000015 - 0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00008 - 0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00006 - 0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.000006
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide
Mus musculus
-
-
0.00014 - 0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
0.00196
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00015
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000076
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00011
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000004
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00405
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00007 - 0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.00131
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00132
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00085
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000037
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.0017
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00047
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00034
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00057
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00019 - 0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.000101
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
Mus musculus
-
-
0.00015
PII protein
Arabidopsis thaliana
-
apparent value, in 100 mM Tricine (pH 8.2), at 30°C
-
0.000411
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000028
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00006
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0029
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000099 - 0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.000024
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0025
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00057 - 0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
0.0058 - 0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
0.0045 - 0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00024
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089 - 0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00073 - 0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00023 - 0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0017
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069 - 0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00033
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0038
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00021
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013 - 0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00021
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0011
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024 - 0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.000052
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00063 - 0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00011 - 0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.01
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00068
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0063
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0036
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000693
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
Homo sapiens
-
ACC1/2
0.03
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
Homo sapiens
-
isozyme ACC2
0.0265
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
Homo sapiens
-
isozyme ACC2
0.0099
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0017
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000178
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000789
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000071
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00258
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000273
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.00183
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000246
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000335
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000486
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000227
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000355
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000231
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000244
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000258
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000159
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000004
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM
0.000011
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the wild-type enzyme in crude extract 11 nM
0.000091
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
0.000037
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM
0.000288
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
, for IC50 for the wild-type enzyme in crude extract 288 nM
0.00054
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
0.001
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.00162
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000163
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.001
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.00132
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000634
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000061
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000031
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0000045
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000017
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000076
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000058
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00017
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00013
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0002
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000049
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000061
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000059
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0000081
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00002
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000023
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000014
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000016
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000027
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000049
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000166
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000391
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000079
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000032
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000033
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000064
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00004
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000009
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000018
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000012
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.0000045
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.00003
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000085
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000013
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000044
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.051
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
Setaria viridis
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
0.076
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
Eleusine indica
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
0.00184
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.00206
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000718
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000753
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000188
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000214
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.038
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
0.054
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
0.0025
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
0.0057
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
0.0035
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
0.017
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
0.00075
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000023
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000034
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000126
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00146
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.000841
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00428
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.0009
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
Setaria viridis
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
0.0046
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
Eleusine indica
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
0.0018
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
Setaria viridis
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
0.028
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
Eleusine indica
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000012
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000019
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000051
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000065
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000104
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000016
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Rattus norvegicus
-
ACC1
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000011
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Rattus norvegicus
-
ACC1
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.0035
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
0.0043
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
0.000022
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000064
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000013
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00139
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000001
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM
0.000008
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Escherichia coli
-
IC 50 for the wild-type enzyme in crude extract 8 nM
0.00005
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
0.000013
andrimid
Escherichia coli
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
0.000305
andrimid
Staphylococcus aureus
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
0.00007
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00028
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00059
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000066
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.002112
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.008
CP-640186
Saccharomyces cerevisiae
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site
0.0014
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00025
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000006
moiramide B
Escherichia coli
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, competitive with respect to malonyl-CoA, noncompetitive to biocytin, IC50 for the purified recombinant su
0.000096
moiramide B
Staphylococcus aureus
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 96 nM
0.000089
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000035
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000113
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.000017
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000033
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.0000044
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000054
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000036
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC1
0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC2
0.000296
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC1
0.00055
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC2
0.000348
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000005
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.025
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00265
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00063
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000259
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
value above, pH and temperature not specified in the publication
0.00004
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000024
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0078
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0099
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0023
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0001
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00092
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0018
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000015
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00003
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00017
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00036
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00038
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
IC50 above 0.01 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC1
0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC2
0.00128
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00007
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.014
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0074
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.02
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00075
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00178
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00452
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0067
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0127
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00062
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00067
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0057
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.011
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000099
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00057
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0058
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00073
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00063
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00011
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.000086 - 0.000096
-
transgenic tubers highly overexpressing the Arabidopsis thaliana enzyme
0.0025
1.336
recombinant N-terminal deletion mutant treated with Lambda protein phosphatase, pH 7.4, 37°C
1.363
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 5 mM citrate
14.6
154.9
-
purified plastidic enzyme from strain Rothamsted, pH 8.0, 30°C
2.246
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 10 mM citrate
3.5
4.186
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 20 mM citrate
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.4 - 6.9
7.4
7.5
8 - 8.5
8.2
8.3
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
32
37
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50 - 75
Q877I4; Q877I3; Q877I5
50°C: about 60% of maximal activity, 75°C: about 60% of maximal activity
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
acetyl-CoA carboxylase and propionyl-CoA carboxylase are different enzymes
-
-
brenda
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
-
-
brenda
the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
-
-
brenda
Q877I4: biotin carboxyl carrier protein of acetyl-CoA carboxylase, Q877I3: carboxyltransferase subunit of acetyl-CoA carboxylase, Q877I5: biotin carboxylase subunit of acetyl-CoA carboxylase
Q877I4; Q877I3; Q877I5
UniProt
brenda
black grass, an arable weed, 297 populations distributed across six countries in central Europe and the Turkey
-
-
brenda
-
1430, 37593, 37606, 37615, 37617, 37618, 651675, 664193, 664350, 664564, 665523, 665526, 672120, 695014
-
-
brenda
P0ABD5 i.e. subunit alpha, P0A9Q5 i.e. subunit beta
UniProt
brenda
-
-
-
brenda
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
brenda
isozyme ACC2; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
brenda
fragment
UniProt
brenda
slighly different sequences found in different plants; herbicide resistant strain AUS92
SwissProt
brenda
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha
SwissProt
brenda
isozyme ACC2; gene ACACB, encoding isozyme ACC2 or ACC-beta
Q6JIZ0
SwissProt
brenda
-
37571, 37579, 37584, 37585, 37586, 37590, 37591, 37592, 37593, 37599, 37603, 37607, 37609, 37612, 665526, 671950, 676971, 691556
-
-
brenda
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha
GenBank
brenda
isozyme ACC2; gene ACACB, encoding isozyme ACC2 or ACC-beta
GenBank
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
ACC1 is the predominant isoform in human umbilical vein endothelial cells as well as in human microvascular endothelial cells
brenda
-
circulating, of nondiabetic and type 2 diabetic individuals, female and male
brenda
additional information
-
ACC and other lipogenic enzymes are present n the hypothalamus, the human tissue shows 2-3fold lower actiivity compared to the rat tissue
brenda
-
brenda
-
2 isoforms: non-mesophyll chloroplast form and mesophyll chloroplast form
brenda
-
-
37571, 37579, 37586, 37592, 37593, 37599, 37609, 37612, 665526, 671950, 693951, 702619, 705505, 714466, 715851
brenda
-
maximal activity in seed line 9686 is around 40 days after flowering, maximal activity in seed line Wayne is around 30 days after flowering
brenda
additional information
-
ACC1 is found primarily in lipogenic tissues such as the liver and adipose tissue whereas ACC2 is the predominate form found in oxidative tissues, skeletal muscle and heart
brenda
additional information
-
differential distribution of acetyl-CoA carboxylase isoforms in mammalian tissues
brenda
additional information
tissue-specific expression of isozymes
brenda
additional information
tissue-specific expression of isozymes
brenda
additional information
ACC1 and ACC2 tissue expression pattern, overview
brenda
additional information
-
ACC1 is found primarily in lipogenic tissues such as the liver and adipose tissue whereas ACC2 is the predominate form found in oxidative tissues, skeletal muscle and heart
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
gene accD encoding the beta-subunit is located in the plastid
brenda
additional information
-
gene accD encoding the beta-subunit is located in the plastid
brenda
-
plastidic isozyme, associated with the chloroplast envelope
brenda
-
2 isoforms: non-mesophyll chloroplast form and mesophyll chloroplast form
brenda
-
plastidic isozyme, associated with the chloroplast envelope
brenda
-
plastidic isozyme, associated with the chloroplast envelope
brenda
-
plastidic isozyme, associated with the chloroplast envelope
brenda
-
plastidic isozyme, associated with the chloroplast envelope
brenda
-
plastidic isozyme, associated with the chloroplast envelope
brenda
-
the enzyme is anchored to the outer membrane of the mitochondrion
brenda
-
Hfa1p is a mitochondrion-specific enzyme and contains a canonical mitochondrial targeting sequence with a matrix protease cleavage site
brenda
-
Hfa1p is a mitochondrion-specific enzyme and contains a canonical mitochondrial targeting sequence with a matrix protease cleavage site
-
brenda
presence of a chloroplast transit peptide
brenda
-
brenda
additional information
subcellular location of isozymes, overview
-
brenda
additional information
Q6JIZ0
subcellular location of isozymes, overview
-
brenda
additional information
subcellular location of isozymes, overview
-
brenda
additional information
subcellular location of isozymes, overview
-
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
malfunction
-
in procyclic forms, ACC RNAi results in 50-75% reduction in fatty acid elongation and a 64% reduction in growth in low-lipid media. In bloodstream forms, ACC RNAi results in a minor 15% decrease in fatty acid elongation and no growth defect in culture, even in low-lipid media. ACC RNAi does attenuate virulence in a mouse model of infection
malfunction
-
inhibition of ACC1 through either RNA interference or inhibitor treatment (0.01 mg/ml 5-tetradecyloxy-2-furoic acid) attenuates human cytomegalovirus replication
malfunction
-
transfer DNA insertional alleles that completely eliminate the accumulation of subunit BCCP2 have no perceptible effect on plant growth, development, and fatty acid accumulation. In contrast, transfer DNA insertional null allele of the CAC1A gene for subunit BCCP1 is embryo lethal and deleteriously affects pollen development and germination. Reducing BCCP1 accumulation to 35% of wild type levels, decreases fatty acid accumulation and severely affects normal vegetative plant growth
malfunction
-
reducing ACC1 expression results in globally increased histone acetylation and altered transcriptional regulation
metabolism
-
acetyl-CoA carboxylase is the rate limiting enzyme in de novo lipid synthesis
metabolism
-
ACC is required for elongation of fatty acids, both laurate and myristate are elongated to products up to 18 carbons
physiological function
-
acetyl-CoA carboxylase plays important roles in modulating energy metabolism
physiological function
-
ACC is required by procyclic forms for growth in culture under lipid-limited conditions and by bloodstream forms for full virulence in mice
physiological function
-
ACCase is a key enzyme initiating the synthesis of fatty acids in plastids
physiological function
-
Acc1p activity regulates the availability of acetyl-CoA for histone acetyltransferases and provide an additional link between intermediary metabolism and histone acetylation and transcriptional regulation
physiological function
in a biotype resistant to five ACCase inhibitor herbicides tested the transcription of ACCase is 3.4-9.3 times higher than in the susceptible biotype. ACCase gene copy number is 5-7 times higher in the resistant compared with the susceptible biotype. ACCase gene overexpression is directly related to the increase of the ACCase gene copy number
physiological function
inactivation of the putative mitochondrial targeting sequence leads to decreased lipoylation and mitochondrial fragmentation
physiological function
inhibition of Acc1 in endotheial cells shifts the lipid composition of membranes. Membrane fluidity, filopodia formation, and migratory capacity are reduced. The antimigratory action of inhibition depends on an increase in the cellular proportion of polyunsaturated fatty acids and on a decreased level of phosphatidylglycerol
physiological function
specific knockdown of Acc1 leads to decreased lipoylation and mitochondrial fragmentation. Simultaneous knockdown of ACSF3, encoding a mitochondrial malonyl-CoA synthetase, results in almost complete ablation of protein lipoylation
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10000000
-
gel filtration enzyme exists in two polymeric forms of MW 2000000 and 10000000, interconvertible by phosphorylation and dephosphorylation. The 10000000 MW form predomionantly exists in preparations of freeze-clamped liver
110000
-
x * 110000, ultracentrifugation in presence of 6 M guanidine hydrochloride and 0.1 M 2-mercaptoethanol
12000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
200000
2000000
-
gel filtration enzyme exists in two polymeric forms of MW 2000000 and 10000000,interconvertible by phosphorylation and dephosphorylation. The 2000000 MW form predominates in preparations of unfrozen liver and is converted to the 10000000 MW form by dephosphorylation
210000
219000
220000
227000
230000
240000
250000
252000
265000
272000
-
x * 272000, and a minor band at 265000 MW, hindlimb muscle, SDS-PAGE
280000
47000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
480000
500000
528000
540000
57000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
600000
-
greater than 600000 Da, gel filtration, complex from alpha and beta subunit of caroxyltransferase
65000
72000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
800000
-
greater than 800000 Da, gel filtration, complex from biotin carboxylase and biotin carboxyl carrier protein
230000
-
2 * 230000, nonidentical, SDS-PAGE. The enzyme exists as a protomer of 480000 MW and as polymeric filaments
250000
-
x * 250000, SDS-PAGE, 2 polymeric forms of MW 2000000 Da, and MW 10000000 Da
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
heteromer
-
the enzyme is composed of four subunits: biotin carboxyl carrier protein, biotin carboxylase, alpha-carboxyltransferase, and beta-carboxyltransferase
monomer
multimer
oligomer
polymer
tetramer
additional information
?
-
multisubunit complex consisting of a 1. biotin carboxylase subunit, 2. a biotin-carboxyl carrier protein, 3. carboxyltransferase alpha- and beta-subunits
?
-
plastid-localized enzyme, 4 different types of subunits: 1. biotin carboxyl carrier subunit, 2. biotin carboxylase subunit, 3. alpha-subunit of carboxyltransferase, 4. beta-subunit of carboxyltransferase
?
-
4 component polypeptides: 1. Biotin carrier protein, MW 170000, 2. biotin carboxylase, which assembles as a dimer of two 49000 MW subunits, 3. and 4. the alpha-subunit and beta-subunit of carboxyl transferase, which assemble as a 130000 MW alpha2beta2 tetramer
?
-
x * 265000-280000, exist minimally as dimers under non-denaturing conditions. When activated by dicarboxylic acids and tricarboxylic acids, which induce aggregation into elongated polymers it consists of 5-20 dimers. Two major form of animal acety-CoA carboxylase: ACC1 is the 265000 MW ACC-alpha-isoform, ACC-2 is the 275000-280000 MW ACC-beta-isoform
?
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
?
-
x * 240000-260000, SDS-PAGE of enzyme dissociated in 1% SDS, 8 M urea and 5 mM DTT
?
-
x * 110000, ultracentrifugation in presence of 6 M guanidine hydrochloride and 0.1 M 2-mercaptoethanol
dimer
-
2 * 230000, nonidentical, SDS-PAGE. The enzyme exists as a protomer of 480000 MW and as polymeric filaments
dimer
wild-type enzyme, and L1705I and V1967I mutant enzymes, light scattering
multimer
-
most likely (alpha,beta,gamma)4 composition, two large subunits of 57000 Da: biotin carboxylase (alpha subunit) and carboxyl transferase (gamma subunit), 18600 Da biotin carrier protein (beta subunit)
multimer
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
most likely (alpha,beta,gamma)4 composition, two large subunits of 57000 Da: biotin carboxylase (alpha subunit) and carboxyl transferase (gamma subunit), 18600 Da biotin carrier protein (beta subunit)
-
multimer
most likely (alpha,beta,gamma)4 composition, two large subunits of 57000 Da: biotin carboxylase (alpha subunit) and carboxyl transferase (gamma subunit), 18600 Da biotin carrier protein (beta subunit)
multimer
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
most likely (alpha,beta,gamma)4 composition, two large subunits of 57000 Da: biotin carboxylase (alpha subunit) and carboxyl transferase (gamma subunit), 18600 Da biotin carrier protein (beta subunit)
-
multimer
-
most likely (alpha,beta,gamma)4 composition, two large subunits of 57000 Da: biotin carboxylase (alpha subunit) and carboxyl transferase (gamma subunit), 18600 Da biotin carrier protein (beta subunit)
polymer
-
x * 250000, SDS-PAGE, 2 polymeric forms of MW 2000000 Da, and MW 10000000 Da
polymer
-
x * 240000-260000, SDS-PAGE, polymeric form shows filamentous structure
tetramer
-
heterotetrameric plastidic enzyme form, the heterotetramer is composed of the subunits biotin carboxyl carrier protein BCCP, biotin carboxylase BC, and alpha and beta subunits of the carboxyltransferase CT
tetramer
-
heterotetrameric plastidic enzyme form, the heterotetramer is composed of the subunits biotin carboxyl carrier protein BCCP, biotin carboxylase BC, and alpha and beta subunits of the carboxyltransferase CT
tetramer
-
the four subunits are encoded by genes accA, accB, accC, and accD
tetramer
-
the heterotetramer is composed of the subunits biotin carboxyl carrier protein BCCP of 17 kDa, biotin carboxylase BC of 49 kDa, and alpha and beta subunits of the carboxyltransferase CT of 35 kDa and 33 kDa
tetramer
-
heterotetrameric plastidic enzyme form, the heterotetramer is composed of the subunits biotin carboxyl carrier protein BCCP, biotin carboxylase BC, and alpha and beta subunits of the carboxyltransferase CT
tetramer
-
heterotetrameric plastidic enzyme form, the heterotetramer is composed of the subunits biotin carboxyl carrier protein BCCP of 21 kDa, biotin carboxylase BC of 53 kDa, and alpha and beta subunits of the carboxyltransferase CT of 91 kDa and 67 kDa
additional information
-
plants possess a homomeric single polypeptide enzyme form in the cytosol, and a heterotetrameric plastidic enzyme form
additional information
-
plants possess a homomeric single polypeptide enzyme form in the cytosol, and a heterotetrameric plastidic enzyme form
additional information
-
MW of biotin carboxylase subunit of acetyl-CoA carboxylase: 16688, calculation from nucleotide sequence
additional information
-
domain structure, evolution and functional domains, overview
additional information
-
multisubunit enzyme consisting of biotin carboxylase, biotin carboxyl carrier protein and the alpha and beta subunits of carboxyltransferase, protein dissociates into two complexes in presence of 0.5 M KCl, when subunit complexes of biotin carboxylase and biotin carboxyl carrier protein and alpha and beta subunits of carboxyltransferase are expressed separately the activity of full size protein can be achieved by mixing the enzyme subunit complexes
additional information
-
a large, multi-domain single polypeptide enzyme which forms complexes of several protomers, domain organization, overview, polymerization is promoted by citrate, isocitrate, malonate, sulfate, and phosphate, while long-chain fatty acids promote the complex dissociation
additional information
domain structure and organization, evolution and functional domains, overview
additional information
domain structure and organization, evolution and functional domains, overview
additional information
-
a large, multi-domain single polypeptide enzyme which forms complexes of several protomers, overview, polymerization is promoted by citrate, isocitrate, malonate, sulfate, and phosphate, while long-chain fatty acids promote the complex dissociation
additional information
domain structure and organization, evolution and functional domains, overview
additional information
Q6JIZ0
domain structure and organization, evolution and functional domains, overview
additional information
-
plants possess a homomeric single polypeptide enzyme form in the cytosol, and a heterotetrameric plastidic enzyme form
additional information
-
multisubunit enzyme consisting of biotin carboxylase, biotin carboxyl carrier protein and the alpha and beta subunits of carboxyltransferase
additional information
-
plants possess a homomeric single polypeptide enzyme form in the cytosol, and a heterotetrameric plastidic enzyme form
additional information
-
a large, multi-domain single polypeptide enzyme which forms complexes of several protomers, overview, polymerization is promoted by citrate, isocitrate, malonate, sulfate, and phosphate, while long-chain fatty acids promote the complex dissociation
additional information
domain structure and organization of the isozyme, evolution and functional domains, overview
additional information
domain structure and organization of the isozyme, evolution and functional domains, overview
additional information
-
a large, multi-domain enzyme, domain organization, structure analysis, overview
additional information
-
domain structure, evolution and functional domains, overview
additional information
-
domain structure determination of beta-subunit encoded by accD, the enzyme contains five motifs at the C-terminus but none at the N-terminus, overview
additional information
-
the alpha- and beta-subunits of the carboxyltransferase domain are shared with the propionyl-CoA carboxylase, EC 6.4.1.3
additional information
-
the core catalytic beta-subunit is a homohexameric complex of 360 kDa, structure overview, the dimeric interaction is crucial for enzyme catalysis, stability, and substrate specificity, interaction between alpha- and beta-subunits, overview
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
additional information
phosphoprotein
-
Acc1 and Acc2 can be phosphorylated by protein kinase A and cAMP depndent protein kinase, overview
phosphoprotein
reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview
phosphoprotein
-
ACC is phosphorylated at Ser79 and thereby inactivated by AMP-activated protein kinase, AMPK, which is induced by UV light and H2O2. AMPK phosphorylates both isozymes of ACC, ACC1 and ACC2
phosphoprotein
-
Ser1263 of ACCA is phosphorylated in vivo, in a cell cycle-dependent manner, by the BRCA1 protein leading to reduced ACCA activity, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
phosphoprotein
phosphorylation decreases ACC2 catalytic activity whereas dephosphorylation activates the enzymatic function by 2fold. Recombinant protein expressed in Bombyx mori exhibits posttranslational phosphorylation
phosphoprotein
-
Acc1 and Acc2 can be phosphorylated by protein kinase A and cAMP depndent protein kinase, overview
phosphoprotein
Q5SWU9, Q6JIZ0
reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview
phosphoprotein
-
reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview
phosphoprotein
-
AMP-activated protein kinase phosphorylates and inactivates enzyme activity
phosphoprotein
-
AMP-activated protein kinase phosphorylates and inactivates enzyme activity in liver
phosphoprotein
-
enzyme is phosphorylated and inactivated by AMP-activated protein kinase
phosphoprotein
-
Acc1 and Acc2 can be phosphorylated by protein kinase A and cAMP depndent protein kinase, overview
phosphoprotein
the enzyme in liver is regulated by reversible phosphorylation, differential phosphorylation of isozymes, overview
phosphoprotein
-
ACC is inactivated by phosphorylation through AMP-activated protein kinase, AMPK, citrate treatment inhibits 75% of control hypothalamic AMPK phosphorylation during fasting, overview
phosphoprotein
-
activated AMP-activated protein kinase, AMPK, phosphorylates and inhibits acetyl-CoA carboxylase, AMPK is itself regulated by reversible phosphorylation
phosphoprotein
-
enzyme is phosphorylated and inactivated by AMP-activated protein kinase
-
additional information
-
the enzyme is biotinylated at the biotinyl domain of subunit AccB by the biotin-[acetyl-CoA carboxylase] ligase BirA, EC 6.3.4.15
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of Escherichia coli biotinylated biotin carboxyl carrier protein (BCCP) complexed with biotin carboxylase (BC) to a resolution of 2.49 A. The protein-protein complex shows a unique quaternary structure and two distinct interfaces for each biotinylated biotin carboxyl carrier protein monomer
crystal structure of humanized mutant of yeast CT (yCT-H9) in complex with a human ACC2-selective small molecule inhibitor is determined
crystallization of the carboxyltranferase domain CT in complex with CoA, inhibitor CP-640186, or herbicides haloxyfop or diclofop
-
enzyme CT domain in complex with inhibitor tepraloxydim, hanging drop vapour diffusion method, at 4°C, 10 mg/ml protein in solution containing 0.1 M sodium citrate, pH 7.5, 8% w/v PEG 8000, 10% v/v glycerol, 5 mM tepraloxydim, and 5% v/v dimethyl sulfoxide, is mixed with reservoir solution containing 0.1 M sodium citrate, pH 5.5,8% w/v PEG 8000, and 10% v/v glycerol, X-ray diffraction structure determination and analysis at 2.3 A resolution
purified recombinant carboxyltransferase domain comprising residues 1476-2233 in complex with CP-640186, hanging drop vapour diffusion method, crystallization of the free enzyme in a 10 mg/ml solution using a reservoir solution containing 0.1 M sodium citrate, pH 5.5, 0.2 M NaCl, 8% w/v PEG 8000, and 10% v/v glycerol, soaking of the crystals in 1 mM inhibitor CP-640186, X-ray diffraction structure determination and analyis at 2.8 A resolution
-
purified selenomethionyl biotin carboxylase domain free and with bound inhibitor soraphen A, sitting drop vapour diffusion method for crystallization of free enzyme: 4°C, the reservoir solution contains 0.1 M Bis-Tris propane, pH 6.0, 23% w/v PEG 3350, 0.2 M NaCl, 0.4 M MgCl2, and 5% glycerol, 12-18 days, followed by microseeding, which is essential, sitting drop vapour diffusion method for crystallization of inhibitor-bound enzyme: 50 mg/ml protein are incubated with 0.88 mM soraphen A at 4°C for 1 h prior to crystallization, the reservoir solution for crystallization at 22°C contains 0.1 M Bis-Tris, pH 5.8, 26% w/v PEG 3350, 0.1 M NaCl, 0.2 M MgCl2, 8% glycerol, and 2 mM DTT, as for the free enzyme microseeding is essential, X-ray diffraction structure determination and analysis at 1.8-2.9 A resolution, selenomethionyl multiwavelength anomalous diffraction method
purified wild-type enzyme and mutant enzymes, free or in complex with inhibitors haloxyfop or diclofop, 10 mg/ml protein with reservoir solution containing 0.1 M sodium citrate, pH 5.5, 0.2 M NaCl, 8% w/v PEG 8000, and 10% v/v glycerol, complexing by soaking of crystals in 5 mM inhibitor solution, cryoprotection by 25% v/v ethylene glycol, X-ray diffraction structure determination and analysis at 2.5-2.8 A resolution
structure of the full-length, 500 kD holoenzyme dimer. The central region contains five domains and is important for positioning the biotin carboxylase and carboxyltransferase domains for catalysis. The structure reveals a dimer of the biotin carboxylase domain
structure of the non-catalytic central domain, to 3.0 A resolution. Structure shows a four-domain organization. A regulatory loop, which is phosphorylated at the key functional phosphorylation site, wedges into a crevice between two domains of the central domain. Large-scale conformational changes are required for substrate turnover. comparison with structure of human enzyme
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
D2078G
-
naturally occuring mutation that confers resistance to ACCase inhibitors fenoxaprop, clodinafop, haloxyfop, cycloxydim, clethodim
G2096A
-
naturally occuring mutation that confers resistance to ACCase inhibitors fenoxaprop, clodinafop and haloxyfop, and probably also to clethodim
I1781L
-
naturally occuring mutation that confers resistance to ACCase inhibitors fenoxaprop, clodinafop and haloxyfop, and to cycloxydim, and probably also to clethodim
I1781L/W2027C/I2041N/D2078G/G2096A
-
naturally occuring mutant ACCase isoforms in Alopecurus myosuroides show resistance to five ACCase inhibitors, i.e. fenoxaprop, clodinafop, haloxyfop, cycloxydim, clethodim, phenotypes, overview
I2041N
-
naturally occuring mutation that confers resistance to ACCase inhibitors fenoxaprop, clodinafop and haloxyfop
W2027C
-
naturally occuring mutation that confers resistance to ACCase inhibitors fenoxaprop, clodinafop and haloxyfop
G199S
-
construction and isolation of a mutant strain less sensitive to moiramide B derivative cpd2 compared to the wild-type strain
C5493T
the single nucleotide polymorphism is associated with fat yield but not with a structural change in the enzyme
I1781L
Q1756E
resistant to sethoxydim
K73E
mutation in the biotin carboxylase domain dimer interface, loss of catalytic activity
L1705I
site-directed mutagenesis, the mutant enzyme shows 100fold decreased activity and 10fold increased Km for malonyl-CoA, but unaltered Ki for haloxyfop compared to the wild-type enzyme
L1705I/V1967I
P1760S/I1762L/M1765V/E1919Q/P1920A/H1925F/Q2028E/M2030T/G2032E
humanized mutant of yeast CT domain is generated by replacing nine active site residues of yeast CT domain with corresponding human ACC2 CT domain residues. This humanized yeast CT domain (yCT-H9) exhibits an inhibitor sensitivity profile similar to that of human ACC while maintaining high recombinant expression yields and robust crystallizability
R76E
mutation in the biotin carboxylase domain dimer interface, loss of catalytic activity
S1157A
-
mutation in potential site of phosphorylation, results in 9fold higher specific activity following glucose depletion
V1967I
site-directed mutagenesis, the mutant enzyme shows 100fold decreased activity and 10fold increased Km for malonyl-CoA, but unaltered Ki for haloxyfop compared to the wild-type enzyme
W487A
mutation in the biotin carboxylase domain dimer interface, loss of catalytic activity
G196S
-
construction and isolation of a mutant strain less sensitive to moiramide B derivative (E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide compared to the wild-type strain
I420D
-
site-directed mutagenesis of AccB, exchange of a single amino acid results in interconversion of substrate specificity of acetyl-CoA carboxylase ACC and propionyl-CoA carboxylase, PCC, EC 6.4.1.3, thus the mutant enzyme does not utilize acetyl-CoA as a substrate, but propionyl-CoA
additional information
I1781L
resistant to sethoxydim
L1705I/V1967I
site-directed mutagenesis, the mutant enzyme shows 100fold decreased activity and 10fold increased Km for malonyl-CoA, but unaltered Ki for haloxyfop compared to the wild-type enzyme
L1705I/V1967I
-
the mutant is not more sensitive to FOP herbicides than the wild-type enzyme
additional information
-
five mutant ACCase isoforms in black-grass: Leu1781, Cys2027, Asn2041, Gly2078, and Ala2096, genotyping, overview
additional information
-
construction of transgenic potato plants by overexpression of the Arabidopsis thaliana isozyme ACC1 in the amyloplast of Solanum tuberosum tubers leads to an increased fatty acid synthesis and a 5fold increased amount of triacylglycerol in the tubers
additional information
-
missense mutation of the biotin carboxylase domain located at the active site disrupts catalysis
additional information
mutations gurke, gk-SC allele, and pasticcino3, pas3-1 and pas3-2 alleles, affect cell division and the bilateral symmetry due to severe defects in the apical region, the mutations are allelic to the lethal acc1 mutation, acc1-1 and acc1-2 alleles, leading to a similar phenotype in embryos, altered fatty acid composition, the phenotype can be partially complemented by malonate, overview
additional information
-
a constructed truncation mutant of subunit AccB comprising the 68 N-terminal residues is sufficient for negative regulation of accBC operon transcription, an accA and accB null mutant strain expressing the accB gene of Rhizobium trifolii is not reduced in growth under conditions that result in highly reduced growth for the wild-type strain
additional information
-
construction and isolation of mutant a strain resistant to moiramide B derivative (E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
additional information
-
construction and isolation of mutant a strain resistant to moiramide B derivative (E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
additional information
-
deletion of downstream sequences affects the response to 3,5,3'-triiodothyronine
additional information
deletion of the N-terminal 148 hydrophobic amino acids to enhance the solubility of heterologous protein expressed in Bomby mori. Expression of the deletion mutant leads to a high yield of recombinant protein
additional information
-
deletion of the N-terminal 148 hydrophobic amino acids to enhance the solubility of heterologous protein expressed in Bomby mori. Expression of the deletion mutant leads to a high yield of recombinant protein
additional information
-
ACC2 knockout mutant mice are protected against diet-induced obesity and diabetes and show a 80% increased palmitate oxidation level in adipocytes which remains increased in presence of insulin, also the glucose oxidation is 2fold increased in mutant mice compared to wild-type mice
additional information
-
ACC2-deficient mice show continous fatty acid oxidation and reduced body weight and body fat
additional information
downregulation of the enzyme by siRNA transfected into the INS-1-derived cell line 832/13 affects insulin secretion, the enzyme activity in 832/13 cells and islets is reduced by 46-80% compared to the untreated cells, and glucose-stimulated insulin secretion is reduced by 70% in 832/13 cells and by 33% in islets, phenotypes, overview
additional information
-
mutants of genes HFA1 and ACC1 shows different phenotypes and the enzymes cannot complement each other, the mitochondrial enzyme Hfa1p disruption mutant strain shows about 90% reduced lipoic acid concentration and does not grow on lactate or glycerol, complementation of hfa1 null mutants require full length HFA1 DNA including the mitochondrial targeting sequence, without the sequence the cDNA encoding the mitochondrial enzyme can complement the cytoplasmic acc1-defective mutant, overview
additional information
deletion of the alpha-helical hairpin (alpha8-alpha9, residues 940-972) in domain AC1 or the beta4A-beta4B loop in the C domain of carboxyltransferase (residues 1902-1916) abolishes the catalytic activity
additional information
-
deletion of the alpha-helical hairpin (alpha8-alpha9, residues 940-972) in domain AC1 or the beta4A-beta4B loop in the C domain of carboxyltransferase (residues 1902-1916) abolishes the catalytic activity
additional information
-
mutants of genes HFA1 and ACC1 shows different phenotypes and the enzymes cannot complement each other, the mitochondrial enzyme Hfa1p disruption mutant strain shows about 90% reduced lipoic acid concentration and does not grow on lactate or glycerol, complementation of hfa1 null mutants require full length HFA1 DNA including the mitochondrial targeting sequence, without the sequence the cDNA encoding the mitochondrial enzyme can complement the cytoplasmic acc1-defective mutant, overview
-
additional information
-
construction of transgenic potato plants by overexpression of the Arabidopsis thaliana isozyme ACC1 in the amyloplast of tubers leads to an increased fatty acid synthesis and a 5fold increased amount of triacylglycerol in the tubers, up to 10fold increased enzyme activity in transgenic plants
additional information
-
formation of chimeric complexes with subunits, wild-type and mutant D422I, of the propionyl-CoA carboxylase, PCC, EC 6.4.1.3, and with mutant subunit AccB I420D of the acetyl-CoA carboxylase
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8
-
rapid inactivation above. Dissociation of the tetrameric native enzyme in a mixture of monomers, dimers and trimers
37583
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
50 - 90
Q877I4; Q877I5; Q877I3
the activity of the enzyme gradually decreases at 50°C, with a residual activity of around 60% after 2 h of incubation. At 60°C, the residual activity of the enzyme is 50% after incubation for 35 to 40 min, whereas the residual activities at 70 and 80°C are less than 15%. The enzyme completely loses its activity within 10 min when it is incubated at 90°C or above
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
bovine serum albumin, HCO3-, citrate, and glycerol required for stabilization
-
DTT, glycerol, Triton X-100, and high concentrations of the enzyme are required for stability
-
high concentrations of enzyme are required for stability as well as the presence of DTT, glycerol, HCO3-, Triton X-100, and polyvinylpyrrolidone
-
low ionic strength and alkaline pH favor the rapid inactivation of the enzyme
-
requires bovine serum albumin, HCO3-, citrate, and glycerol for stabilization
-
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ORGANIC SOLVENT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Glycerol
20 and 30% glycerol can stabilize the enzyme for a period up to 4 weeks
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 0.1 M potassium phosphate, 0.5 mM EDTA, pH 7.3, 1 mM DTT, 10 mM trisodium citrate, 15 mM NaHCO3, 0.1% bovine serum albumin, 15% v/v glycerol, stable for 2 months
-
-20°C, 0.3 M potassium phosphate, 50% glycerol, pH 6.5, stable for at least 1 year
-
-20°C, 100 mM sodium phosphate, 25 mM sodium citrate, pH 7.0, 35% ethanediol, stable for at least 1 month
-
-30C or -70C, 20% glycerol or ethylene glycol, 100 mM KCl, 7 or 14 mM 2-mercaptoethanol, stable for at least several weeks
-80°C, in 20 mM Tris-HCl (pH 7.5) containing 0.3M NaCl, 10% glycerol, and 5 mM DTT, 4 days, rapid loss of activity
20°C, 100 mM sodium phosphate, 25 mM sodium citrate, pH 7.0, stable for several days
-
20°C, 50 mM imidazole HCl, 0.1 mM EDTA, 0.02% sodium azide, 20% glycerol, 25 mM citrate, pH 7.5, stable for up to 1 week
-
5°C, under N2, 20 mM sodium citrate, 10 mM potassium phosphate buffer, pH 7.5, 1 mM EDTA, 1 mM DTT, protein concentration greater than 2 mg/ml, stable for 1 week
-
-30C or -70C, 20% glycerol or ethylene glycol, 100 mM KCl, 7 or 14 mM 2-mercaptoethanol, stable for at least several weeks
-
-30C or -70C, 20% glycerol or ethylene glycol, 100 mM KCl, 7 or 14 mM 2-mercaptoethanol, stable for at least several weeks
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
478fold by ammonium sulfate fractionation, ion exchange chromatography, ultrafiltration, and gel filtration
-
c-Myc-5 monoclonal IgG column chromatography and Sephacryl S-300 gel filtration
large-scale purification of of intact 156-residue biotin carboxyl carrier subunit of the acetyl-CoA carboxylase and the truncated 87000 residue COOH-terminal fragment
-
native enzyme from liver by two steps of ammonium sulfate fractionation, and anion exchange chromatography
-
Ni affinity resin column chromatography, Q Sepharose HP column chromatography, and Superdex 200 gel filtration
Ni-affinity column chromatography and gel filtration
partial
partially from liver by avidin affinity chromatography including a batch step
-
partially from young leaves by ammonium sulfate fractionation
rapid purification is of particular use in the isolation of acetyl CoA carboxylase from plant tissues which are prone to proteolysis
-
recombinant enzyme from Sf9 insect cells by ammonium sulfate fractionation and anion exchange chromatography
-
recombinant full length enzyme and His-tagged BC domain from Escherichia coli, the latter by nickel affinity chromatography
recombinant His-tagged biotin carboxylase domain from Escherichia coli strain BL21(DE3) by nickel affinity chromatography, anion exchange chromatography, and gel filtration
recombinant His-tagged carboxyltransferase domain comprising residues 1548-2346 from Escherichia coli by nickel affinity and ion exchange chromatography
-
recombinant His-tagged enzyme from Escherichia coli strain XL 1-Blue by nickel affinity chromatography
-
recombinant His-tagged enzyme subunits AccA and AccD from Escherichia coli strain XL 1-Blue by nickel affinity chromatography
-
recombinant His-tagged enzyme subunits AccA and AccD from strain XL 1-Blue by nickel affinity chromatography
-
separation of two isoforms
Streptavidin column chromatography and Superose 6 gel filtration
Q877I4; Q877I5; Q877I3
using Ni-NTA chromatography
c-Myc-5 monoclonal IgG column chromatography and Sephacryl S-300 gel filtration
-
c-Myc-5 monoclonal IgG column chromatography and Sephacryl S-300 gel filtration
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
ACCase genotyping, frequencies of plants resistant to two broadly used ACCase inhibitors, identification of seven mutant, resistant ACCase alleles, referred to as C-L1781, T-L1781, C-C2027, T-C2027, N2041, G2078 and A2096. Resistance and ACCase allele distribution patterns are characterized by mosaicism, and not endowed by mutant ACCase alleles, overview
-
carboxyltransferase and biotin carboxylase subunit, expressed in Escherichia coli
-
cloning and expression of the CT domain comprising residues 1476-2233
DNA and amino acid sequence determination and analysis
DNA and amino acid sequence determination and analysis of the plastidic isozyme
-
DNA and amino acid sequence determination and analysis of the plastidic isozyme, genes accA-accD encode the 4 subunits, expression of the carboxyltransferase subunit
-
DNA and amino acid sequence determination and analysis, alternative splicing, overview
DNA and amino acid sequence determination and analysis, alternative splicing, the gene encoding isozyme ACC-beta is located on chromosome 12q24, overview
DNA and amino acid sequence determination and analysis, chromosome 12 of all genotypes contains an ACACA pseudogene named acaca-psi, alternative splicing, overview
Q5SWU9, Q6JIZ0
DNA and amino acid sequence determination and analysis, one gene encodes both isozymes, alternative splicing, long and short enzyme forms with different subcellular localization
-
DNA and amino acid sequence determination and analysis, sequence determination of promoter III of the goat gene encoding the enzyme, genotyping of 211 samples of different races for the single nucleotide polymorphism C5493T, realtive allele frequency, overview
DNA of different subunits imported into isolated chloroplast from Pisum sativum, proteins expressed in Escherichia coli accumulate in inclusion bodies
-
each subunit individually cloned, carboxyl transferase expressed in Escherichia coli
expressed in baculovirus-infected High Five insect cells as N-terminal His-tagged fusion proteins
expressed in Escherichia coli as a His-tagged fusion protein
expressed in Sf9 cells
expression analysis of biotin-related genes in leukocytes related to biotin deficiency, overview
expression analysis of genes involved in energy metabolism, including gene Acc2, in wild-type and Acc2-knockout mutant mice
-
expression in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method
-
expression of His-tagged enzyme subunits AccA and AccD in Escherichia coli strain XL 1-Blue
-
expression of His-tagged enzyme subunits AccA and AccD in strain XL 1-Blue
-
expression of subunits AccA2, AccB, and AccE, and of mutant AccB in Escherichia coli
-
expression of the BC domains in Escherichia coli strain BL21(DE3)
expression of the His-tagged carboxyltransferase domain comprising residues 1548-2346 in Escherichia coli
-
functional expression of the full length enzyme, and expression of the His-tagged BC domain in Escherichia coli
gene ACC1, DNA and amino acid sequence determination of wild-type and mutants acc1, gk, and pas
gene accD, constitutive expression, transcription analysis, DNA and amino acid sequence determination and analysis
-
gene dedB, i.e. accD, encoding the beta subunit of the carboxyltransferase
-
gene hfa1, expression analysis, complementation of an acc1-defective mutant yeast strain
-
genes acc1 and acc2, Oryza sativa lacks the accD gene which encodes for the biotin carboxyl carrier protein in plants other than the Gramineae
-
genes acc1 and acc2, Triticum aestivum lacks the accD gene which encodes for the biotin carboxyl carrier protein in plants other than the Gramineae
-
genes accA, accB, accC, and accD, operon accBC shows nonlinear response to the gene copy number so that 50 or more copies result in an only 2-3fold increase in subunits AccB and AccC, AccB is a negative regulator for transcription of the accBC operon
-
humanized mutant of yeast CT domain is expressed in Escherichia coli
overexpression of a biotin-domain peptide from the biotin carboxy carrier protein of acetyl-CoA carboxylase
-
overexpression of isozyme ACC1 in the amyloplast of Solanum tuberosum tubers using the Agrobacterium transfection system
-
overexpression of the His-tagged biotin carboxylase domain in Escherichia coli strain BL21(DE3) and as selenomethionyl enzyme in strain B834(DE3)
regulation of acc expression, overview
subunit BCCP is encoded by 2 genes, while the other 3 subunits are single gene-encoded
-
DNA and amino acid sequence determination and analysis, alternative splicing, overview
-
DNA and amino acid sequence determination and analysis, alternative splicing, overview
expressed in baculovirus-infected High Five insect cells as N-terminal His-tagged fusion proteins
-
expressed in baculovirus-infected High Five insect cells as N-terminal His-tagged fusion proteins
-
expression of the BC domains in Escherichia coli strain BL21(DE3)
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
accumulation of BCCP1 is 5ffold higher than that of BCCP2 in developing siliques
-
human cytomegalovirus infection activates ACC1 expression about 3fold 72 h post infection, increasing the abundance of both ACC1 mRNA and protein. Viral gene expression but not viral DANN replication is necessary for human cytomegalovirus-mediated induction of ACC1 levels
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
agriculture
biofuel production
biotechnology
drug development
pharmacology
-
pharmacological inhibition of the ACC system is of potential use for treatment of key components of the metabolic syndrome, plasma and hepatic metabolic parameters after fasting and after the hyperinsulinaemic euglycaemic clamp, overview
synthesis
agriculture
in a biotype resistant to five ACCase inhibitor herbicides tested the transcription of ACCase is 3.4-9.3 times higher than in the susceptible biotype. ACCase gene copy number is 5-7 times higher in the resistant compared with the susceptible biotype. ACCase gene overexpression is directly related to the increase of the ACCase gene copy number
biofuel production
-
Saccharomyces cerevisiae is engineered to produce fatty acid-derived biofuels and chemicals from simple sugars. All three primary genes involved in fatty acid biosynthesis, namely ACC1, FAS1 and FAS2 are overexpressed. Combining this metabolic engineering strategy with terminal converting enzymes (diacylglycerol-acyltransferase,fatty acyl-CoA thioesterase,fatty acyl-CoA reductase, and wax ester synthase for TAG,fatty acid, fatty alcohol and FAEE production, respectively) improves the production levels of all biofuel molecules and chemicals, Saccharomyces cerevisiae provides a compelling platform for a scalable, controllable and economic route to biofuel molecules and chemicals
biofuel production
-
Saccharomyces cerevisiae is engineered to produce fatty acid-derived biofuels and chemicals from simple sugars. All three primary genes involved in fatty acid biosynthesis, namely ACC1, FAS1 and FAS2 are overexpressed. Combining this metabolic engineering strategy with terminal converting enzymes (diacylglycerol-acyltransferase,fatty acyl-CoA thioesterase,fatty acyl-CoA reductase, and wax ester synthase for TAG,fatty acid, fatty alcohol and FAEE production, respectively) improves the production levels of all biofuel molecules and chemicals, Saccharomyces cerevisiae provides a compelling platform for a scalable, controllable and economic route to biofuel molecules and chemicals
-
drug development
-
the enzyme is a target for drug development in case of obesity, diabetes, and other symptoms of the metabolic syndrome
drug development
-
the structure of the enzyme's active site can be used for drug discovery
drug development
-
inhibition of ACC demonstrates promising therapeutic potential for treating obesity and type 2 diabetes mellitus in transgenic mice and preclinical animal models
drug development
-
the enzyme is a target for drug development in treatment of obesity
synthesis
expression in Bombyx mori using the silkworm NPV bacmid system. Recombinant protein shows biotinylation capacity,and exhibits posttranslational biotinylation and phosphorylation
synthesis
-
in yeast engineered to produce the polyketide 6-methylsalisylic acid (6-MSA), both 6-MSA and native fatty acid levels increase by 3fold in presence of mutant S1157A which is not deactivated when glucose is depleted
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Release 2023.1 (January 2023)
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