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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylosuccinate synthetase, adssl1, adss1, adenylosuccinate synthase, pfadss, adss2, ampss, succino-amp synthetase, adenylosuccinate synthetase 1, as-synthetase,
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adenosylsuccinate synthetase
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Adenylosuccinate synthase
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Adenylosuccinate synthetase
IMP--aspartate ligase
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IMP-aspartate ligase
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Succino-AMP synthetase
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Succinoadenylic kinosynthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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AMPSase
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
random sequential binding mechanism
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IMP:L-aspartate ligase (GDP-forming)
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GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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function in adenine nucleotide biosynthesis
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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function in adenine nucleotide biosynthesis
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Cu2+
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10.9% of the activation relative to Mg2+
additional information
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Ca2+
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14.1% of the activation relative to Mg2+
Ca2+
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16.2% of the activation relative to Mg2+
Co2+
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34.8% of the activation relative to Mg2+
Co2+
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21.3% of the activation relative to Mg2+
Mg2+
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Mg2+
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full activity in presence of Mg2+
Mn2+
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37% of the activation relative to Mg2+
Mn2+
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43.2% of the activation relative to Mg2+
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Ca2+
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in presence of Mg2+
Cd2+
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in presence of Mg2+
Cu2+
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in presence of Mg2+
fructose 1,6-diphosphate
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basic type M isozym more strongly inhibited than acidic type L isozym
Hg2+
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reversed by addition of DTT
Mn2+
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in presence of Mg2+
nucleotides
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acidic type L isozyme more strongly inhibited than basic type M isozyme
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Pb2+
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in presence of Mg2+
Zn2+
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in presence of Mg2+
additional information
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overview
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0.25
Asp
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skeletal muscle
0.25 - 0.36
Asp
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muscle enzyme
0.33
Asp
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liver basic type L isozyme
0.36 - 1.47
Asp
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acidic liver type L isozym
1.47
Asp
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liver basic type M isozyme
0.004 - 0.38
GTP
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muscle enzyme
0.015 - 0.13
GTP
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liver acidic type L isozyme
0.09
GTP
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liver basic type L isozyme
0.12
GTP
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skeletal muscle
0.13
GTP
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liver basic type L isozyme
0.03 - 0.32
IMP
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liver acidic type L isozyme
0.2 - 0.7
IMP
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muscle enzyme
0.32
IMP
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liver basic type L isozyme
0.69
IMP
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liver basic isozyme
0.7
IMP
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skeletal muscle
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additional information
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5.5 - 8.5
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50% of maximal activity at pH 5.5 and 8.5
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brenda
2 isozymic forms: acidic type L, and basic type M
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brenda
rat
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
additional information
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tissue distribution of L-isozyme and M-isozyme
brenda
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A0A8I6A7H6_RAT
431
0
47763
TrEMBL
Mitochondrion (Reliability: 4)
A0A8I6GA01_RAT
362
0
40029
TrEMBL
other Location (Reliability: 3)
A0A8I6AT75_RAT
452
0
49558
TrEMBL
other Location (Reliability: 3)
A0A8I6G9X7_RAT
460
0
50261
TrEMBL
other Location (Reliability: 4)
D4AEP0_RAT
456
0
50085
TrEMBL
other Location (Reliability: 3)
A0A8I6G7N1_RAT
226
0
24461
TrEMBL
other Location (Reliability: 3)
M0R629_RAT
457
0
50250
TrEMBL
other Location (Reliability: 4)
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102000
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Yoshida sarcoma ascites tumor cells, sedimentation equilibrium analysis
104000
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sedimentation equilibrium analysis
47000
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2 * 47000, sedimentation equilibrium analysis in presence of 6 M guanidine-HCl
52000
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2 * 52000, SDS-PAGE
55000 - 60000
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liver and Novikoff ascites cells
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dimer
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2 * 47000, sedimentation equilibrium analysis in presence of 6 M guanidine-HCl
dimer
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2 * 52000, SDS-PAGE
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7
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most stable at pH 7.0 in phosphate buffer
1539
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-20°C, or 0°C, rapid loss of enzyme activity in dilute solution
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gene Adss1, quantitative RT-PCR analysis
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Cooper, B.F.; Fromm, H.J.; Rudolph, F.B.
Isotope exchange at equilibrium studies with rat muscle adenylosauccinate synthetase
Biochemistry
25
7323-7327
1986
Rattus norvegicus
brenda
Stayton, M.M.; Rudolph, F.B.; Fromm, H.J.
Regulation, genetics, and properties of adenylosuccinate synthetase
Curr. Top. Cell. Regul.
22
103-141
1983
Azotobacter vinelandii, Bacillus subtilis, Gallus gallus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Leishmania donovani, Rattus norvegicus, Schizosaccharomyces pombe, Sus scrofa, Triticum aestivum, Trypanosoma cruzi
brenda
Matsuda, Y.; Shimura, K.; Shiraki, H.; Nakagawa, H.
Purification and properties of adenylosuccinate synthetase from Yoshida sarcoma ascites tumor cells
Biochim. Biophys. Acta
616
340-350
1980
Rattus norvegicus
brenda
Matsuda, Y.; Ogawa, H.; Fukutome, S.; Shiraki, H.; Nakagawa, H.
Adenylosuccinate synthetase in rat liver: the existence of two types and their regulatory roles
Biochem. Biophys. Res. Commun.
78
766-771
1977
Rattus norvegicus
brenda
Ogawa, H.; Shiraki, H.; Matsuda, Y.; Kakiuchi, K.; Nakagawa, H.
Purification, crystallization, and properties of adenylosuccinate synthetase from rat skeletal muscle
J. Biochem.
81
859-869
1977
Rattus norvegicus
brenda
Honzatko, R.B.; Stayton, M.M.; Fromm, H.J.
Adenylosuccinate synthetase: Recent developments
Adv. Enzymol. Relat. Areas Mol. Biol.
73
57-102
1999
Azotobacter vinelandii, Acidithiobacillus ferrooxidans, Arabidopsis thaliana, Bacillus subtilis, Oryctolagus cuniculus, Dictyostelium discoideum, Escherichia coli, Haemophilus influenzae, Homo sapiens, Leishmania donovani, Methanocaldococcus jannaschii, Mus musculus, Pyrococcus sp., Rattus norvegicus, Schizosaccharomyces pombe, Triticum aestivum, Trypanosoma cruzi, Zea mays, Pyrococcus sp. ST700
brenda
Wen, H.Y.; Xia, Y.; Young, M.E.; Taegtmeyer, H.; Kellems, R.E.
The adenylosuccinate synthetase-1 gene is activated in the hypertrophied heart
J. Cell. Mol. Med.
6
235-243
2002
Mus musculus, Rattus norvegicus
brenda
6.3.4.4 adenylosuccinate synthase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
