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The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylosuccinate synthetase, adssl1, adss1, adenylosuccinate synthase, pfadss, adss2, ampss, succino-amp synthetase, adenylosuccinate synthetase 1, as-synthetase,
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Adenylosuccinate synthase
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Adenylosuccinate synthetase
IMP--aspartate ligase
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IMP-aspartate ligase
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Succino-AMP synthetase
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Succinoadenylic kinosynthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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AMPSase
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
fully random terter mechanism
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IMP:L-aspartate ligase (GDP-forming)
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GTP + IMP + L-Asp
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plays an important role in the interconversion of purines
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GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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GTP + IMP + L-Asp
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plays an important role in the interconversion of purines
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GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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Formycin B monophosphate
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guanosine 5'-(beta,gamma-imino)triphosphate
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Hadacidin
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5 mM, 100% inhibition
N-(Thiocarboxy)-L-aspartic anhydride
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5 mM, 27.5% inhibition
N-Acetyl-N-hydroxyglycine
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5 mM, 72.9% inhibition
N-acetylglycine
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5 mM, 51.2% inhibition
N-benzoylglycine
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5 mM, 6% inhibition
N-formylglycine
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5 mM, 61.1% inhibition
N-hydroxyglycine
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5 mM, 49.3% inhibition
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0.03
Asp
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IMP
0.023
GTP
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PURA_DICDI
427
0
47285
Swiss-Prot
other Location (Reliability: 1)
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-70°C, stable for more than 2 years
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Jahngen, E.G.E.; Rossomando, E.F.
Adenylosuccinate synthetase from Dictyostelium discoideum: effects of hadacidin analogs and binding of [14C]hadacidin
Arch. Biochem. Biophys.
229
145-154
1984
Dictyostelium discoideum
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Wiesmuller, L.; Wittbrodt, J.; Noegel, A.A.; Schleicher, M.
Purification and cDNA-derived sequence of adenylosuccinate synthetase from Dictyostelium discoideum
J. Biol. Chem.
266
2480-2485
1991
Dictyostelium discoideum
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Honzatko, R.B.; Stayton, M.M.; Fromm, H.J.
Adenylosuccinate synthetase: Recent developments
Adv. Enzymol. Relat. Areas Mol. Biol.
73
57-102
1999
Azotobacter vinelandii, Acidithiobacillus ferrooxidans, Arabidopsis thaliana, Bacillus subtilis, Oryctolagus cuniculus, Dictyostelium discoideum, Escherichia coli, Haemophilus influenzae, Homo sapiens, Leishmania donovani, Methanocaldococcus jannaschii, Mus musculus, Pyrococcus sp., Rattus norvegicus, Schizosaccharomyces pombe, Triticum aestivum, Trypanosoma cruzi, Zea mays, Pyrococcus sp. ST700
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