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Information on EC 6.3.4.4 - adenylosuccinate synthase and Organism(s) Arabidopsis thaliana

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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.4 adenylosuccinate synthase
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This record set is specific for:
Arabidopsis thaliana
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylosuccinate synthetase, adssl1, adss1, adenylosuccinate synthase, pfadss, adss2, ampss, succino-amp synthetase, adenylosuccinate synthetase 1, mouse muscle synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Adenylosuccinate synthase
-
-
-
-
Adenylosuccinate synthetase
AMPSase
IMP--aspartate ligase
-
-
-
-
IMP-aspartate ligase
-
-
-
-
Succino-AMP synthetase
-
-
-
-
Succinoadenylic kinosynthetase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
IMP:L-aspartate ligase (GDP-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9023-57-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
show the reaction diagram
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
show the reaction diagram
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,4-dihydro-4-(beta-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one
-
-
Hydantocidin 5'-phosphate
-
-
N-Acetyl-5'-phosphohydantocidin
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PURA_ARATH
490
0
52964
Swiss-Prot
Chloroplast (Reliability: 3)
A0A7G2EXI6_ARATH
480
0
51877
TrEMBL
Mitochondrion (Reliability: 4)
A0A178VIV3_ARATH
439
0
47149
TrEMBL
Chloroplast (Reliability: 3)
Q8LEZ6_ARATH
490
0
52976
TrEMBL
Chloroplast (Reliability: 3)
A0A5S9XNF3_ARATH
490
0
52964
TrEMBL
Chloroplast (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
2 * 55000
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
space group I23, cell constants a = b = c = 212.76 A
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Siehl, D.L.; Subramanian, M.V.; Walters, E.W.; Lee, S.F.; Anderson, R.J.; Toschi, A.G.
Adenylosuccinate synthetase: site of action of hydantocidin, a microbial phytotoxin
Plant Physiol.
110
753-758
1996
Arabidopsis thaliana, Zea mays
Manually annotated by BRENDA team
Honzatko, R.B.; Stayton, M.M.; Fromm, H.J.
Adenylosuccinate synthetase: Recent developments
Adv. Enzymol. Relat. Areas Mol. Biol.
73
57-102
1999
Azotobacter vinelandii, Acidithiobacillus ferrooxidans, Arabidopsis thaliana, Bacillus subtilis, Oryctolagus cuniculus, Dictyostelium discoideum, Escherichia coli, Haemophilus influenzae, Homo sapiens, Leishmania donovani, Methanocaldococcus jannaschii, Mus musculus, Pyrococcus sp., Rattus norvegicus, Schizosaccharomyces pombe, Triticum aestivum, Trypanosoma cruzi, Zea mays, Pyrococcus sp. ST700
Manually annotated by BRENDA team
Prade, L.; Cowan-Jacob, S.W.; Chemla, P.; Potter, S.; Ward, E.; Fonne-Pfister, R.
Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana
J. Mol. Biol.
296
569-577
2000
Triticum aestivum (O24396), Triticum aestivum, Arabidopsis thaliana (Q96529), Arabidopsis thaliana
Manually annotated by BRENDA team
Schmitzer, P.R.; Graupner, P.R.; Chapin, E.L.; Fields, S.C.; Gilbert, J.R.; Gray, J.A.; Peacock, C.L.; Gerwick, B.C.
Ribofuranosyl triazolone: A natural product herbicide with activity on adenylosuccinate synthetase following phosphorylation
J. Nat. Prod.
63
777-781
2000
Amaranthus retroflexus, Arabidopsis thaliana, Avena fatua, Echinochloa crus-galli, Helianthus annuus, Setaria faberi, Alopecurus myosuroides, Ipomoea hederacea, Abutilon theophrasti
Manually annotated by BRENDA team