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EC Tree
The taxonomic range for the selected organisms is: Gallus gallus The enzyme appears in selected viruses and cellular organisms
Synonyms
glycinamide ribonucleotide synthetase, gar synthetase, gar-syn, phosphoribosylglycinamide synthetase, phosphoribosylamine-glycine ligase, glycinamide ribotide synthetase, phosphoribosylglycineamide synthetase, 5'-phosphoribosylglycinamide synthetase, prg synthetase, trifunctional purine biosynthetic protein adenosine-3,
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2-Amino-N-ribosylacetamide 5'-phosphate kinosynthase
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5'-Phosphoribosylglycinamide synthetase
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Glycinamide ribonucleotide synthetase
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Glycineamide ribonucleotide synthetase
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Phosphoribosylglycinamide synthetase
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Phosphoribosylglycineamide synthetase
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Synthetase, phosphoribosylglycinamide
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ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
mechanism
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5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
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ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
ATP + 5-phospho-D-ribosylamine + glycine
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ADP in form of MgADP-
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r
ATP + 5-phospho-D-ribosylamine + Gly
ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
ATP + 5-phosphoribosylamine + beta-Ala
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ATP + 5-phosphoribosylamine + Gly
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
ATP + 5-phosphoribosylamine + sarcosine
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ATP + carbocyclic 5-phosphoribosylamine + Gly
ADP + phosphate + carbocyclic glycinamide ribonucleotide
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r
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additional information
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ATP + 5-phospho-D-ribosylamine + Gly
ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
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ATP + 5-phospho-D-ribosylamine + Gly
ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
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ATP + 5-phosphoribosylamine + Gly
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enzyme of purine biosynthetic pathway
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ATP + 5-phosphoribosylamine + Gly
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enzyme of the de novo purine biosynthetic pathway
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
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ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
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additional information
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requirement for ATP and a substrate with a carboxyl group or its relatives, transfer of a phosphate group from ATP to the carboxyl group or its relatives
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additional information
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second step in de novo purine biosynthesis pathway
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ATP + 5-phosphoribosylamine + Gly
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additional information
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second step in de novo purine biosynthesis pathway
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ATP + 5-phosphoribosylamine + Gly
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enzyme of purine biosynthetic pathway
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ATP + 5-phosphoribosylamine + Gly
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enzyme of the de novo purine biosynthetic pathway
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0.04588
(+/-)-carbocyclic glycinamide ribonucleotide
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0.00247 - 0.13
5'-phosphoribosylglycinamide
0.00247
5'-phosphoribosylglycinamide
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0.02
5'-phosphoribosylglycinamide
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0.03
5'-phosphoribosylglycinamide
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0.13
5'-phosphoribosylglycinamide
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2.3
5'-phosphoribosylglycinamide
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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brenda
trifunctional enzyme with phosphoribosylamine-glycine ligase activity, glycinamide ribonucleotide transformylase activity, and aminoimidazole ribonucleotide synthetase activity
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brenda
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brenda
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PUR2_CHICK
1003
0
106544
Swiss-Prot
other Location (Reliability: 4 )
C5J075_CHICK
368
0
39072
TrEMBL
other Location (Reliability: 4 )
A0A1D5NU16_CHICK
863
0
93387
TrEMBL
Mitochondrion (Reliability: 5 )
A0A3Q2U3P5_CHICK
433
0
45990
TrEMBL
other Location (Reliability: 4 )
A0A547_CHICK
1003
0
106529
TrEMBL
other Location (Reliability: 4 )
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additional information
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MW 49000, GAR domain of the trifunctional enzyme, gel filtration
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GAR domain of the multifunctional enzyme has a MW of 49000, SDS-PAGE, the multifunctional enzyme has a MW of 110000, SDS-PAGE
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on repeated freeze-thawing activity is lost due to the precipitation of protein
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-20°C, stable for many weeks
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copurification of phosphoribosylamine-glycine ligase and glycinamide ribonucleotide transformylase
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Schrimsher, J.L.; Schendel, F.J.; Stubbe, J.
Isolation of a multifunctional protein with aminoimidazole ribonucleotide synthetase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase activities: characterization of aminoimidazole ribonucleotide synthetase
Biochemistry
25
4356-4365
1986
Gallus gallus
brenda
Daubner, S.C.; Young, M.; Sammons, R.D.; Courtney, L.F.; Benkovic, S.J.
Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis
Biochemistry
25
2951-2957
1986
Gallus gallus, Homo sapiens
brenda
Daubner, S.C.; Schrimsher, J.L.; Schendel, F.J.; Young, M.; Henikoff, S.; Patterson, D.; Stubbe, J.; Benkovic, S.J.
A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis
Biochemistry
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7059-7062
1985
Gallus gallus
brenda
Cheng, Y.S.; Murray, M.; Schendel, F.; Otvos, J.; Wehrli, S.; Stubbe, J.
Chemical characterization of phosphoribosylamine, a substrate for newly discovered trifunctional protein containing glycinamide ribonucleotide synthetase activity
Adv. Enzyme Regul.
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319-333
1987
Gallus gallus, Drosophila melanogaster, Escherichia coli, Schizosaccharomyces pombe
brenda
Antle, V.D.; Liu, D.; McKellar, B.R.; Caperelli, C.A.; Hua, M.; Vince, R.
Substrate specificity of glycinamide ribonucleotide synthetase from chicken liver
J. Biol. Chem.
271
8192-8195
1996
Gallus gallus
brenda
Caperelli, C.A.; Liu, D.
Carbocyclic substrates for de novo purine biosynthesis. Enantiospecific synthesis and enantiospecificity of enzymatic utilization
J. Biol. Chem.
267
9783-9787
1992
Gallus gallus
brenda
Kanai, S.; Toh, H.
Identification of new members of the GS ADP-forming family from the de novo purine biosynthesis pathway
J. Mol. Evol.
48
482-492
1999
Synechocystis sp., Arabidopsis thaliana, Archaeoglobus fulgidus, Bacillus subtilis, Saccharomyces cerevisiae, Yarrowia lipolytica, Gallus gallus, Drosophila melanogaster, Drosophila pseudoobscura, Escherichia coli, Haemophilus influenzae, Homo sapiens, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Mus musculus, Pyrococcus horikoshii, Salmonella enterica subsp. enterica serovar Typhimurium, Schizosaccharomyces pombe, Chironomus tentans, Pyrococcus horikoshii OT-3
brenda