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Information on EC 6.3.4.13 - phosphoribosylamine-glycine ligase and Organism(s) Drosophila melanogaster

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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.13 phosphoribosylamine-glycine ligase
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This record set is specific for:
Drosophila melanogaster
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Word Map
  • 6.3.4.13
  • transformylase
  • aminoimidazole
  • formyltransferase
  • amidotransferase
  • phosphoribosylaminoimidazole
  • phosphoribosylpyrophosphate
  • medicine
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
glycinamide ribonucleotide synthetase, gar synthetase, gar-syn, phosphoribosylglycinamide synthetase, phosphoribosylamine-glycine ligase, glycinamide ribotide synthetase, phosphoribosylglycineamide synthetase, prg synthetase, trifunctional purine biosynthetic protein adenosine-3, garsase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-Amino-N-ribosylacetamide 5'-phosphate kinosynthase
-
-
-
-
5'-Phosphoribosylglycinamide synthetase
-
-
-
-
GAR synthetase
-
-
-
-
GARS
-
-
-
-
GARSase
-
-
-
-
Glycinamide ribonucleotide synthetase
-
-
-
-
Glycineamide ribonucleotide synthetase
-
-
-
-
Phosphoribosylglycinamide synthetase
-
-
-
-
Phosphoribosylglycineamide synthetase
-
-
-
-
PRG synthetase
-
-
-
-
Synthetase, phosphoribosylglycinamide
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
show the reaction diagram
mechanism
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9032-01-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 5-phospho-D-ribosylamine + Gly
ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
show the reaction diagram
-
-
-
?
ATP + 5-phosphoribosylamine + Gly
ADP + phosphate + 5-phosphoribosylglycinamide
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
second step in de novo purine biosynthesis pathway
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR2_DROME
1353
0
144448
Swiss-Prot
Mitochondrion (Reliability: 5)
F3YDH3_DROME
1353
0
144572
TrEMBL
Mitochondrion (Reliability: 5)
X2J516_DROME
1353
0
144525
TrEMBL
Mitochondrion (Reliability: 5)
Q59DZ6_DROME
434
0
45864
TrEMBL
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
-
x * 45000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cheng, Y.S.; Murray, M.; Schendel, F.; Otvos, J.; Wehrli, S.; Stubbe, J.
Chemical characterization of phosphoribosylamine, a substrate for newly discovered trifunctional protein containing glycinamide ribonucleotide synthetase activity
Adv. Enzyme Regul.
26
319-333
1987
Gallus gallus, Drosophila melanogaster, Escherichia coli, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Kanai, S.; Toh, H.
Identification of new members of the GS ADP-forming family from the de novo purine biosynthesis pathway
J. Mol. Evol.
48
482-492
1999
Synechocystis sp., Arabidopsis thaliana, Archaeoglobus fulgidus, Bacillus subtilis, Saccharomyces cerevisiae, Yarrowia lipolytica, Gallus gallus, Drosophila melanogaster, Drosophila pseudoobscura, Escherichia coli, Haemophilus influenzae, Homo sapiens, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Mus musculus, Pyrococcus horikoshii, Salmonella enterica subsp. enterica serovar Typhimurium, Schizosaccharomyces pombe, Chironomus tentans, Pyrococcus horikoshii OT-3
Manually annotated by BRENDA team