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Information on EC 6.3.3.1 - phosphoribosylformylglycinamidine cyclo-ligase and Organism(s) Homo sapiens

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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.3 Cyclo-ligases
                6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
air synthetase, aminoimidazole ribonucleotide synthetase, phosphoribosylaminoimidazole synthetase, phosphoribosylformylglycinamidine cyclo-ligase, 5'-phosphoribosyl-5-aminoimidazole synthetase, phosphoribosyl-aminoimidazole synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5'-Aminoimidazole ribonucleotide synthetase
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-
-
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5'-Phosphoribosyl-5-aminoimidazole synthetase
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-
-
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AIR synthase
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-
-
-
AIR synthetase
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-
-
-
AIRS
-
-
-
-
Phosphoribosyl-aminoimidazole synthetase
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-
-
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Phosphoribosylaminoimidazole synthetase
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-
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Synthetase, phosphoribosylaminoimidazole
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-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
show the reaction diagram
mechanism
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9023-53-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR2_HUMAN
1010
0
107767
Swiss-Prot
Mitochondrion (Reliability: 5)
Q3B7A7_HUMAN
1010
0
107723
TrEMBL
Mitochondrion (Reliability: 5)
Q59HH3_HUMAN
1046
1
112138
TrEMBL
Mitochondrion (Reliability: 5)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
copurification of AIR synthetase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of the trifunctional enzyme with AIR synthetase activity, phosphoribosylglycinamide synthetase activity, and phosphoribosylglycinamide transformylase activity, in mutant CHO cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Daubner, S.C.; Young, M.; Sammons, R.D.; Courtney, L.F.; Benkovic, S.J.
Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis
Biochemistry
25
2951-2957
1986
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Chang, F.H.; Barnes, T.S.; Schild, D.; Gnirke, A.; Bleskam, J.; Patterson, D.
Expression of a human cDNA encoding a protein containing GAR synthetase, AIR synthetase, and GAR transformylase corrects the defects in mutant Chinese hamster ovary cells lacking these activities
Somat. Cell Mol. Genet.
17
411-420
1991
Homo sapiens
Manually annotated by BRENDA team