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Information on EC 6.3.3.1 - phosphoribosylformylglycinamidine cyclo-ligase and Organism(s) Drosophila melanogaster

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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.3 Cyclo-ligases
                6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
air synthetase, aminoimidazole ribonucleotide synthetase, phosphoribosylaminoimidazole synthetase, phosphoribosylformylglycinamidine cyclo-ligase, 5'-phosphoribosyl-5-aminoimidazole synthetase, phosphoribosyl-aminoimidazole synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5'-Aminoimidazole ribonucleotide synthetase
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-
-
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5'-Phosphoribosyl-5-aminoimidazole synthetase
-
-
-
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AIR synthase
-
-
-
-
AIR synthetase
-
-
-
-
AIRS
-
-
-
-
Phosphoribosyl-aminoimidazole synthetase
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-
-
-
Phosphoribosylaminoimidazole synthetase
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-
-
-
Synthetase, phosphoribosylaminoimidazole
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-
-
-
PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9023-53-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
overproduces a large protein with AIR synthetase activity, phosphoribosylglycinamide synthetase activity, and phosphoribosylglycinamide transformylase activity
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR2_DROME
1353
0
144448
Swiss-Prot
Mitochondrion (Reliability: 5)
F3YDH3_DROME
1353
0
144572
TrEMBL
Mitochondrion (Reliability: 5)
K7Z4R2_DROME
329
0
35465
TrEMBL
other Location (Reliability: 3)
X2J516_DROME
1353
0
144525
TrEMBL
Mitochondrion (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Henikoff, S.; Keene, M.A.; Sloan, J.S.; Bleskan, J.; Hards, R.; Patterson, D.
Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila
Proc. Natl. Acad. Sci. USA
83
720-724
1986
Drosophila melanogaster
Manually annotated by BRENDA team