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Information on EC 6.3.2.8 - UDP-N-acetylmuramate-L-alanine ligase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC6.3.2.8
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IUBMB Comments
Involved in the synthesis of a cell-wall peptide in bacteria.
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This record set is specific for:
Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
udp-n-acetylmuramate:l-alanine ligase, murc ligase, udp-n-acetylmuramate-l-alanine ligase, udp-n-acetylmuramoyl:l-alanine ligase, udp-n-acetylmuramic acid l-alanine ligase, l-alanine adding enzyme, uridine diphosphate n-acetylmuramate:l-alanine ligase, udp-n-acetylmuramoyl-l-alanine synthetase, udp-n-acetylmuramyl:l-alanine ligase, udp-murnac:l-alanine ligase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Alanine-adding enzyme
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L-Ala ligase
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L-Alanine adding enzyme
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Synthetase, uridine diphospho-N-acetylmuramoylalanine
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UDP-acetylmuramoyl-L-alanine synthetase
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UDP-MurNAc:L-alanine ligase
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UDP-N-acetylmuramate-alanine ligase
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UDP-N-acetylmuramic acid L-alanine ligase
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UDP-N-acetylmuramoyl-L-alanine synthetase
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UDP-N-acetylmuramoylalanine synthetase
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UDP-N-acetylmuramyl:L-alanine ligase
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Uridine 5´-diphosphate-N-acetylmuramyl-L-alanine synthetase
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Uridine diphosphate N-acetylmuramate:L-alanine ligase
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Uridine diphospho-N-acetylmuramoylalanine synthetase
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Uridine-diphosphate-N-acetylmuramate:L-alanine ligase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxamide formation
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carboxylic acid amide formation
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
Involved in the synthesis of a cell-wall peptide in bacteria.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-52-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
show the reaction diagram
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-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
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(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
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(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
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a pyrazolopyrimidine, is a potent inhibitor of the enzyme and is active against an efflux pump mutant of Pseudomonas aeruginosa, but cellular activity against Pseudomonas aeruginosa is not observed. MIC values for (2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol are over 0.2 mM for wild-type Pseudomonas aeruginosa and 0.0065 mM against the Pseudomonas aeruginosa mutant strain DELTAmexADCDXY
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
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-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
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-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
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(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
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(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
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(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
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(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
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(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
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(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
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(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
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2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
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2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
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additional information
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a class of pyrazolopyrimidines with subnanomolar potency against both Escherichia coli and Pseudomonas aeruginosa MurC enzymes is constructed, which demonstrate a concomitant bactericidal activity against efflux-deficient strains. The compounds selectively inhibit peptidoglycan biosynthesis. In the presence of permeability enhancers such as colistin, pyrazolopyrimidines exhibit low micromolar MIC against the wild-type bacteria, thereby, indicating permeability and efflux as major challenges for this chemical series. Inhibitors evaluation and binding mode of pyrazolopyrimidines, docking study, overview. The antibiotics linezolid, erythromycin, meropenem, ampicillin, and ofloxacin modulate the MIC values of pyrazolopyrimidine compounds in strain Pae546
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000005
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
Pseudomonas aeruginosa
-
below, pH and temperature not specified in the publication
0.0000007
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
Pseudomonas aeruginosa
-
pH 8.0, 25°C, recombinant enzyme
0.0000012
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
Pseudomonas aeruginosa
-
below, pH and temperature not specified in the publication
0.000007
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000009
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000001
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000007
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000002
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000013
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000007
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
Pseudomonas aeruginosa
-
below, pH and temperature not specified in the publication
0.00001
(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008
(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000005
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.00005
(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0001
(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000011
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000013
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
the enzyme is essentially involved in the bacterial peptidoglycan biosynthesis pathway. MurC, the first of four Mur ligases, ligates L-alanine to UDP-N-acetylmuramic acid, initiating the synthesis of pentapeptide precursor
physiological function
-
the enzyme is essential for peptidoglycan biosynthesis. Peptidoglycan is an essential cell wall component of both gram-positive and gram-negative bacteria that protects the cytoplasmic membrane from osmotic stress
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A2R3IPL7_PSEAI
469
1
50796
TrEMBL
-
A0A0A8RLH1_PSEAI
487
1
52974
TrEMBL
-
A0A4P0TDF9_PSEAI
480
1
52068
TrEMBL
-
A0A8G3P1E5_PSEAI
480
1
52010
TrEMBL
-
A0A485GBM0_PSEAI
799
1
86413
TrEMBL
-
A0A431X9J0_PSEAI
480
1
52010
TrEMBL
-
A0A0F6UHG2_PSEAI
480
1
51982
TrEMBL
-
A0A8B5AD24_PSEAI
480
1
52004
TrEMBL
-
A0A8F9JW18_PSEAI
480
1
51966
TrEMBL
-
A0A8F9VAQ0_PSEAI
480
1
51963
TrEMBL
-
A0A8G3ZZZ9_PSEAI
480
1
51952
TrEMBL
-
A0A8G7INR8_PSEAI
480
1
51952
TrEMBL
-
A0A8G3VRS3_PSEAI
480
1
51998
TrEMBL
-
A0A8G2VVI4_PSEAI
480
1
52010
TrEMBL
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
R151W
-
site-directed mutagenesis
Y246C
-
site-directed mutagenesis
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli strain BL21
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
El Zoeiby, A.; Sanschagrin, F.; Lamoureux, J.; Darveau, A.; Levesque, R.C.
Cloning, over-expression and purification of Pseudomonas aeruginosa murC encoding uridine diphosphate N-acetylmuramate: L-alanine ligase
FEMS Microbiol. Lett.
183
281-288
2000
Pseudomonas aeruginosa, Pseudomonas aeruginosa CPAO1
Manually annotated by BRENDA team
Hameed P, S.; Manjrekar, P.; Chinnapattu, M.; Humnabadkar, V.; Shanbhag, G.; Kedari, C.; Mudugal, N.V.; Ambady, A.; de Jonge, B.L.; Sadler, C.; Paul, B.; Sriram, S.; Kaur, P.; Guptha, S.; Raichurkar, A.; Fleming, P.; Eyermann, C.J.; McKinney, D.C.; Sambandamurthy, V.K.; Panda, M.; Ravishankar, S.
Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli
ACS Chem. Biol.
9
2274-2282
2014
Escherichia coli, Pseudomonas aeruginosa, Pseudomonas aeruginosa Pae546
Manually annotated by BRENDA team
Humnabadkar, V.; Prabhakar, K.R.; Narayan, A.; Sharma, S.; Guptha, S.; Manjrekar, P.; Chinnapattu, M.; Ramachandran, V.; Hameed, S.P.; Ravishankar, S.; Chatterji, M.
UDP-N-acetylmuramic acid L-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death
Antimicrob. Agents Chemother.
58
6165-6171
2014
Escherichia coli, Pseudomonas aeruginosa
Manually annotated by BRENDA team