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ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide
?
ATP + (R)-4'-phosphopantothenate + 2-methylcysteine
N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate
ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine
phosphopantetheine + ADP + phosphate
ATP + (R)-4'-phosphopantothenate + cystine
(R)-4'-phosphopantothenoyl-L-cystine + ADP + phosphate
-
5% of activity compared to L-Cys
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
CTP + (R)-4'-phosphopantothenate + L-cysteine
-
-
-
-
r
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
CTP + (R)-4'-phosphopantothenate + L-Cys
?
-
Brown´s pathway of CoA synthesis
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
additional information
?
-
-
ATP, GTP, and UTP cannot substitute for CTP
-
-
?
ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide
?
-
10% of activity compared to L-Cys
-
-
?
ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide
?
-
-
-
-
?
ATP + (R)-4'-phosphopantothenate + 2-methylcysteine
N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate
-
10% of the activity compared to L-cysteine
-
?
ATP + (R)-4'-phosphopantothenate + 2-methylcysteine
N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate
-
-
-
-
?
ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine
phosphopantetheine + ADP + phosphate
-
25% of activity compared to L-Cys
-
?
ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine
phosphopantetheine + ADP + phosphate
-
-
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
8% of the activity with CTP
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
-
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
human enzyme can use both ATP and CTP with similar affinity. Catalysis under CTP conditions displays Michaelis-Menten kinetics
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
mammalian enzyme differs from the bacterial enzyme in that it can use any of the other nucleotide triphosphates equally as well as CTP
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
-
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
-
-
?
ATP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
mammalian enzyme differs from the bacterial enzyme in that it can use any of the other nucleotide triphosphates equally as well as CTP
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
CTP specifically required
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
CTP specifically required
-
-
r
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
human enzyme can use both ATP and CTP with similar affinity. Enzyme shows cooperative binding of ATP, measured as a Hill constant of 1.7
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
CTP specifically required
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-Cys
(R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
CTP specifically required
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
-
r
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
detection of the 4'-phosphopantothenoyl-CMP intermediate
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
detection of the 4'-phosphopantothenoyl-CMP intermediate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
CTP + (R)-4'-phosphopantothenate + L-cysteine
-
-
-
-
r
CTP + (R)-4'-phosphopantothenate + L-Cys
?
-
Brown´s pathway of CoA synthesis
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
-
r
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
?
CTP + (R)-4'-phosphopantothenate + L-cysteine
CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
-
-
?
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Brown, G.M.
The metabolism of pantothenic acid
J. Biol. Chem.
234
370-378
1959
Bacteria, Escherichia coli, Mammalia, Morganella morganii, no activity in Saccharomyces cerevisiae, no activity in Lactobacillus arabinosus, no activity in Lactobacillus helveticus, Rattus norvegicus
brenda
Brohn, F.H.; Trager, W.
Coenzyme A requirement of malaria parasites: enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae
Proc. Natl. Acad. Sci. USA
72
2456-2458
1975
Anas platyrhynchos
brenda
Nishimura, N.; Kakimoto, T.; Chibata, I.
Mechanism of coenzyme A biosynthesis by Sarcina lutea
J. Ferment. Technol.
61
95-99
1983
Micrococcus luteus
-
brenda
Shimizu, S.; Tani, Y.; Ogata, K.
Synthesis of coenzyme A and its biosynthetic intermediates by microbial processes
Methods Enzymol.
62
236-245
1979
Corynebacterium ammoniagenes
brenda
Abiko, Y.
Pantothenic acid and coenzyme A: phosphopantothenoylcysteine synthetase from rat liver (pantothenate 4-phosphate: L-cysteine ligase, EC 6.3.2.5)
Methods Enzymol.
18A
350-354
1976
Rattus norvegicus
-
brenda
Abiko, Y.; Tomikawa, M.; Shimizu, M.
Further studies on phosphopantothenoylcysteine synthetase
J. Biochem.
64
115-117
1968
Rattus norvegicus
brenda
Abiko, Y.
Investigation on pantothenic acid and its related compounds
J. Biochem.
61
290-299
1967
Rattus norvegicus
brenda
Shimizu, S.; Morioka, H.; Tani, Y.; Ogata, K.
A microbial synthesis of pantothenylalcohol 4-phosphate
Agric. Biol. Chem.
42
889-890
1978
Corynebacterium ammoniagenes
-
brenda
Kupke, T.
Active-site residues and amino acid specificity of the bacterial 4'-phosphopantothenoylcysteine synthetase CoaB
Eur. J. Biochem.
271
163-172
2004
Escherichia coli
brenda
Manoj, N.; Strauss, E.; Begley, T.P.; Ealick, S.E.
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution
Structure
11
927-936
2003
Homo sapiens
brenda
Strauss, E.; Kinsland, C.; Ge, Y.; McLafferty, F.W.; Begley, T.P.
Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria
J. Biol. Chem.
276
13513-13516
2001
Escherichia coli
brenda
Kupke, T.
Molecular Characterization of the 4'-Phosphopantothenoylcysteine Synthetase Domain of Bacterial Dfp Flavoproteins
J. Biol. Chem.
277
36137-36145
2002
Escherichia coli
brenda
Stanitzek, S.; Augustin, M.A.; Huber, R.; Kupke, T.; Steinbacher, S.
Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase
Structure
12
1977-1988
2004
Escherichia coli (P0ABQ0), Escherichia coli
brenda
Kupke, T.; Schwarz, W.
4-Phosphopantetheine biosynthesis in archaea
J. Biol. Chem.
281
5435-5444
2006
Methanocaldococcus jannaschii (Q58323), Methanocaldococcus jannaschii DSM 2661 (Q58323)
brenda
Bosveld, F.; Rana, A.; Lemstra, W.; Kampinga, H.H.; Sibon, O.C.
Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis
BMC Res. Notes
1
75
2008
Drosophila melanogaster
brenda
Yao, J.; Patrone, J.D.; Dotson, G.D.
Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis
Biochemistry
48
2799-2806
2009
Enterococcus faecalis
brenda
Yao, J.; Dotson, G.D.
Kinetic characterization of human phosphopantothenoylcysteine synthetase
Biochim. Biophys. Acta
1794
1743-1750
2009
Homo sapiens
brenda
Balibar, C.J.; Hollis-Symynkywicz, M.F.; Tao, J.
Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa
J. Bacteriol.
193
3304-3312
2011
Escherichia coli, Pseudomonas aeruginosa
brenda