Reference on EC 6.3.2.26 - N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kallow, W.; Neuhof, T.; Arezi, B.; Jungblut, P.; von Doehren, H.
Penicillin biosynthesis: intermediates of biosynthesis of delta-L-alpha-aminoadipyl-L-cysteinyl-D-valine formed by ACV synthetase from Acremonium chrysogenum
FEBS Lett.
414
74-78
1997
Acremonium chrysogenum
Kallow, W.; Von Dohren, H.; Kleinkauf, H.
Penicillin biosynthesis: energy requirement for tripeptide precursor formation by delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Acremonium chrysogenum
Biochemistry
37
5947-5952
1998
Acremonium chrysogenum
MacCabe, A.P.; Van Liempt, H.; Palissa, H.; Unkles, S.E.; Riach, M.B.R.; Pfeifer, E.; Von Doehren, H.; Kinghorn, J.R.
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway
J. Biol. Chem.
266
12646-12654
1991
Aspergillus nidulans
Banko, G.; Demain, A.L.; Wolfe, S.
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase (ACV synthetase): a multifunctional enzyme with broad substrate specificity for the synthesis of penicillin and cephalosporin precursors
J. Am. Chem. Soc.
109
2858-2860
1987
Acremonium chrysogenum
-
Baldwin, J.E.; Shiau, C.Y.; Byford, M.F.; Schofield, C.J.
Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products
Biochem. J.
301
367-372
1994
Acremonium chrysogenum, Streptomyces clavuligerus
-
Zhang, J.; Demain, A.L.
Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites
Arch. Microbiol.
158
364-369
1992
Acremonium chrysogenum, Streptomyces clavuligerus
-
Shiau, C.Y.; Byford, M.F.; Baldwin, J.E.; Schofield, C.J.
Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase
Biochem. Soc. Trans.
23
629S
1995
Acremonium chrysogenum
Shiau, C.Y.; Byford, M.F.; Aplin, R.T.; Baldwin, J.E.; Schofield, C.J.
L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation
Biochemistry
36
8798-8806
1997
Acremonium chrysogenum
Zhang, J.; Wolfe, S.; Demain, A.L.
Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus
Biochem. J.
283
691-698
1992
Streptomyces clavuligerus
Coque, J.J.R.; De la Fuente, J.L.; Liras, P.; Martin, J.F.
Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide
Eur. J. Biochem.
242
264-270
1996
Amycolatopsis lactamdurans
Zhang, J.; Demain, A.L.
In vitro stabilization of ACV synthetase activity from Streptomyces clavuligerus
Appl. Biochem. Biotechnol.
37
97-110
1992
Streptomyces clavuligerus
-
Theilgaard, H.B.A.; Kristiansen, K.N.; Henriksen, C.M.; Nielsen, J.
Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum
Biochem. J.
327
185-191
1997
Penicillium chrysogenum
-
Aharonowitz, Y.; Bergmeyer, J.; Cantoral, J.M.; Cohen, G.; Demain, A.L.; Fink, U.; Kinghorn, J.; Kleinkauf, H.; MacCabe, A.; et al.
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase, the multienzyme integrating the four primary reactions in b-lactam biosynthesis, as a model peptide synthetase
Bio/Technology
11
807-810
1993
Acremonium chrysogenum, Acremonium persicinum, Amycolatopsis lactamdurans, Aspergillus nidulans, Lysobacter lactamgenus, Penicillium chrysogenum
Byford, M.F.; Baldwin, J.E.; Shiau, C.Y.; Schofield, C.J.
The mechanism of ACV synthetase
Chem. Rev.
97
2631-2649
1997
Acremonium chrysogenum, Aspergillus nidulans, Penicillium chrysogenum, Streptomyces clavuligerus
Liras, P.; Demain, A.L.
Enzymology of beta-lactam compounds with cephem structure produced by actinomycete
Methods Enzymol.
458
401-429
2009
Actinomyces sp.
Siewers, V.; Chen, X.; Huang, L.; Zhang, J.; Nielsen, J.
Heterologous production of non-ribosomal peptide LLD-ACV in Saccharomyces cerevisiae
Metab. Eng.
11
391-397
2009
Penicillium chrysogenum
Gidijala, L.; Kiel, J.A.; Douma, R.D.; Seifar, R.M.; van Gulik, W.M.; Bovenberg, R.A.; Veenhuis, M.; van der Klei, I.J.
An engineered yeast efficiently secreting penicillin
PLoS ONE
4
e8317
2009
Penicillium chrysogenum
Fernandez-Aguado, M.; Teijeira, F.; Martin, J.F.; Ullan, R.V.
A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum
Appl. Microbiol. Biotechnol.
97
795-808
2013
Penicillium chrysogenum (B6HLU1), Penicillium chrysogenum, Penicillium chrysogenum Wisconsin 54-1255 (B6HLU1)
Wu, X.; Garcia-Estrada, C.; Vaca, I.; Martin, J.F.
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
Biochimie
94
354-364
2012
Penicillium chrysogenum (B6HLU1), Penicillium chrysogenum, Penicillium chrysogenum Wisconsin 54-1255 (B6HLU1)
Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H.
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea
Extremophiles
16
819-828
2012
Thermococcus kodakarensis (Q5JIZ8), Thermococcus kodakarensis
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