Reference on EC 6.3.2.2 - glutamate-cysteine ligase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sriram, R.; Ali-Osman, F.
Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line
Biochem. Mol. Biol. Int.
30
1053-1060
1993
Homo sapiens
Griffith, O.W.; Mulcahy, R.T.
The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase
Adv. Enzymol. Relat. Areas Mol. Biol.
73
209-267
1999
Ascaris suum, Bos taurus, [Candida] boidinii, Ovis aries, Nicotiana tabacum, no activity in Entamoeba histolytica, Proteus mirabilis, Sus scrofa, Xenopus sp., no activity in Giardia sp., Mus musculus (A0A0H2UNM8), Mus musculus (P97494), Escherichia coli (P0A6W9), Rattus norvegicus (P19468), Rattus norvegicus (P48508), Saccharomyces cerevisiae (P32477), Arabidopsis thaliana (P46309), Homo sapiens (P48506), Homo sapiens (P48507), Homo sapiens, Leishmania tarentolae (P90557), Schizosaccharomyces pombe (Q09768), Trypanosoma brucei (Q26820), Acidithiobacillus ferrooxidans (Q56277)
Tu, Z.; Anders, M.W.
Expression and characterization of human glutamate-cysteine ligase
Arch. Biochem. Biophys.
354
247-254
1998
Homo sapiens
Tu, Z.; Anders, M.W.
Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis
Biochem. J.
336
675-680
1998
Homo sapiens
-
Wild, A.C.; Mulcahy, R.T.
Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels
Biochem. J.
338
659-665
1999
Homo sapiens
-
Hamilton, D.; Wu, J.H.; Alaoui-Jamali, M.; Batist, G.
A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production
Blood
102
725-730
2003
Homo sapiens
Myhrstad, M.C.; Carlsen, H.; Nordstrom, O.; Blomhoff, R.; Moskaug, J.O.
Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter
Free Radic. Biol. Med.
32
386-393
2002
Homo sapiens
Dickinson, D.A.; Iles, K.E.; Watanabe, N.; Iwamoto, T.; Zhang, H.; Krzywanski, D.M.; Forman, H.J.
4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells
Free Radic. Biol. Med.
33
974-987
2002
Homo sapiens
Wild, A.C.; Mulcahy, R.T.
Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses
Free Radic. Res.
32
281-301
2000
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Mari, M.; Cederbaum, A.I.
CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase
J. Biol. Chem.
275
15563-15571
2000
Homo sapiens
Misra, I.; Griffith, O.W.
Expression and purification human g-glutamylcysteine synthetase
Protein Expr. Purif.
13
268-276
1998
Homo sapiens
Walsh, A.C.; Feulner, J.A.; Reilly, A.
Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel
Toxicol. Sci.
61
218-223
2001
Homo sapiens
Tiitto, L.H.; Peltoniemi, M.J.; Kaarteenaho-Wiik, R.L.; Soini, Y.M.; Paakko, P.K.; Sormunen, R.T.; Kinnula, V.L.
Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases
Hum. Pathol.
35
832-839
2004
Homo sapiens
Chik, K.; Flourie, F.; Arab, K.; Steghens, J.P.
Kinetic measurement by LC/MS of gamma-glutamylcysteine ligase activity
J. Chromatogr. B
827
32-38
2005
Rattus norvegicus (P19468), Homo sapiens (P48506), Homo sapiens
Takamura, Y.; Fatma, N.; Kubo, E.; Singh, D.P.
Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75
Am. J. Physiol.
290
C554-C566
2006
Homo sapiens
Aguirre, P.; Valdes, P.; Aracena-Parks, P.; Tapia, V.; Nunez, M.T.
Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells
Am. J. Physiol.
292
C2197-C2203
2007
Homo sapiens
Andringa, K.K.; Coleman, M.C.; Aykin-Burns, N.; Hitchler, M.J.; Walsh, S.A.; Domann, F.E.; Spitz, D.R.
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose
Cancer Res.
66
1605-1610
2006
Homo sapiens
Katayama, S.; Ishikawa, S.; Fan, M.Z.; Mine, Y.
Oligophosphopeptides derived from egg yolk phosvitin up-regulate gamma-glutamylcysteine synthetase and antioxidant enzymes against oxidative stress in Caco-2 cells
J. Agric. Food Chem.
55
2829-2835
2007
Homo sapiens
Das, G.C.; Bacsi, A.; Shrivastav, M.; Hazra, T.K.; Boldogh, I.
Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity
Mol. Carcinog.
45
635-647
2006
Homo sapiens
Benassi, B.; Zupi, G.; Biroccio, A.
gamma-Glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells
Mol. Pharmacol.
72
1015-1023
2007
Homo sapiens
Rinna, A.; Forman, H.J.
SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase
Am. J. Respir. Cell Mol. Biol.
39
97-104
2008
Homo sapiens
Siedlinski, M.; Postma, D.S.; van Diemen, C.C.; Blokstra, A.; Smit, H.A.; Boezen, H.M.
Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes
Am. J. Respir. Crit. Care Med.
178
13-19
2008
Homo sapiens
Kishi, T.; Ikeda, M.; Kitajima, T.; Yamanouchi, Y.; Kinoshita, Y.; Kawashima, K.; Inada, T.; Harano, M.; Komiyama, T.; Hori, T.; Yamada, M.; Iyo, M.; Sora, I.; Sekine, Y.; Ozaki, N.; Ujike, H.; Iwata, N.
Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population
Ann. N. Y. Acad. Sci.
1139
63-69
2008
Homo sapiens
Zhang, H.; Shih, A.; Rinna, A.; Forman, H.J.
Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells
Arch. Biochem. Biophys.
481
110-115
2008
Homo sapiens
Chappell, S.; Daly, L.; Morgan, K.; Guetta-Baranes, T.; Roca, J.; Rabinovich, R.; Lotya, J.; Millar, A.B.; Donnelly, S.C.; Keatings, V.; MacNee, W.; Stolk, J.; Hiemstra, P.S.; Miniati, M.; Monti, S.; OConnor, C.M.; Kalsheker, N.
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD
Eur. Respir. J.
32
931-937
2008
Homo sapiens
Langston, W.; Circu, M.L.; Aw, T.Y.
Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Influence of low glucose
Free Radic. Biol. Med.
45
1591-1599
2008
Homo sapiens
Nichenametla, S.N.; Ellison, I.; Calcagnotto, A.; Lazarus, P.; Muscat, J.E.; Richie, J.P.
Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase
Free Radic. Biol. Med.
45
645-650
2008
Homo sapiens
Franklin, C.C.; Backos, D.S.; Mohar, I.; White, C.C.; Forman, H.J.; Kavanagh, T.J.
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
Mol. Aspects Med.
30
86-98
2008
Arabidopsis thaliana, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Liu, X.P.; Goldring, C.E.; Wang, H.Y.; Copple, I.M.; Kitteringham, N.R.; Park, B.K.; Wei, W.
Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC)
Phytother. Res.
22
367-371
2008
Homo sapiens
Asano, T.; Tsutsuda-Asano, A.; Fukunaga, Y.
Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells
Cancer Chemother. Pharmacol.
64
715-721
2009
Homo sapiens
Jackson, R.M.; Gupta, C.
Hypoxia and kinase activity regulate lung epithelial cell glutathione
Exp. Lung Res.
36
45-56
2010
Homo sapiens
Park, H.; Nam, M.; Lee, H.; Jun, W.; Hendrich, S.; Lee, K.
Isolation of caffeic acid from Perilla frutescens and its role in enhancing ?-glutamylcysteine synthetase activity and glutathione level
Food Chem.
119
724-730
2010
Homo sapiens
Biterova, E.I.; Barycki, J.J.
Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase
J. Biol. Chem.
284
32700-32708
2009
Homo sapiens, Saccharomyces cerevisiae (P32477), Saccharomyces cerevisiae
Krejsa, C.M.; Franklin, C.C.; White, C.C.; Ledbetter, J.A.; Schieven, G.L.; Kavanagh, T.J.
Rapid activation of glutamate cysteine ligase following oxidative stress
J. Biol. Chem.
285
16116-16124
2010
Homo sapiens
Kumar, A.; Bachhawat, A.K.
A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
J. Biosci.
35
21-25
2010
Homo sapiens
Oliveira, C.P.; Stefano, J.T.; Cavaleiro, A.M.; Zanella Fortes, M.A.; Vieira, S.M.; Rodrigues Lima, V.M.; Santos, T.E.; Santos, V.N.; de Azevedo Salgado, A.L.; Parise, E.R.; Ferreira Alves, V.A.; Carrilho, F.J.; Correa-Giannella, M.L.
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease
J. Gastroenterol. Hepatol.
25
357-361
2010
Homo sapiens
de Tudela, M.V.; Delgado-Esteban, M.; Cuende, J.; Bolanos, J.P.; Almeida, A.
Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase
J. Neurochem.
113
819-825
2010
Homo sapiens
Cortes-Wanstreet, M.M.; Giedzinski, E.; Limoli, C.L.; Luderer, U.
Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death
Mutagenesis
24
211-224
2009
Homo sapiens
Kimura, T.; Kawasaki, Y.; Okumura, F.; Sone, T.; Natsuki, R.; Isobe, M.
Ethanol-induced expression of glutamate-cysteine ligase catalytic subunit gene is mediated by NF-kappaB
Toxicol. Lett.
185
110-115
2009
Homo sapiens
Willis, M.N.; Liu, Y.; Biterova, E.I.; Simpson, M.A.; Kim, H.; Lee, J.; Barycki, J.J.
Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits
Biochemistry
50
6508-6517
2011
Homo sapiens
Backos, D.S.; Fritz, K.S.; Roede, J.R.; Petersen, D.R.; Franklin, C.C.
Posttranslational modification and regulation of glutamate-cysteine ligase by the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal
Free Radic. Biol. Med.
50
14-26
2011
Homo sapiens, Mus musculus
Le, T.M.; Willis, A.S.; Barr, F.E.; Cunningham, G.R.; Canter, J.A.; Owens, S.E.; Apple, R.K.; Ayodo, G.; Reich, D.; Summar, M.L.
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
Mol. Genet. Metab.
101
55-61
2010
Homo sapiens
Sikalidis, A.K.; Mazor, K.M.; Lee, J.I.; Roman, H.B.; Hirschberger, L.L.; Stipanuk, M.H.
Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits
Amino Acids
46
1285-1296
2014
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Li, M.; Zhang, Z.; Yuan, J.; Zhang, Y.; Jin, X.
Altered glutamate cysteine ligase expression and activity in renal cell carcinoma
Biomed. Rep.
2
831-834
2014
Homo sapiens (P48506 AND P48507), Homo sapiens
Song, W.; Yuan, J.; Zhang, Z.; Li, L.; Hu, L.
Altered glutamate cysteine ligase activity in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
Exp. Ther. Med.
8
195-200
2014
Homo sapiens (P48506 AND P48507), Homo sapiens
Dequanter, D.; van de Velde, M.; Bar, I.; Nuyens, V.; Rousseau, A.; Nagy, N.; Vanhamme, L.; Vanhaeverbeek, M.; Brohee, D.; Delree, P.; Boudjeltia, K.; Lothaire, P.; Uzureau, P.
Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma
Oncol. Lett.
11
3660-3668
2016
Homo sapiens (P48506 AND P48507)
