Reference on EC 6.3.2.13 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Linnett, P.E.; Tipper, D.J.
Cell wall polymers of Bacillus sphaericus: activities of enzymes involved in peptidoglycan precursor synthesis during sporulation
J. Bacteriol.
120
342-354
1974
Lysinibacillus sphaericus, Lysinibacillus sphaericus 9602
Abo-Ghalia, M.; Michaud, C.; Blanot D.; van Heijenoort, J.
Specificity of the uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate synthetase from Escherichia coli
Eur. J. Biochem.
153
81-87
1985
Escherichia coli
Mizuno, Y.; Ito, E.
Diaminopimelic-adding enzyme (Bacillus cereus)
Methods Enzymol.
17B
150-154
1971
Bacillus cereus
-
Mizuno, Y.; Ito, E.
Purification and properties of uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase
J. Biol. Chem.
243
2665-2672
1968
Bacillus cereus
Tipper, D.J.; Linnett, P.E.
Distribution of peptidoglycan synthetase activities between sporangia and forespores in sporulating cells of Bacillus sphaericus
J. Bacteriol.
126
213-221
1976
Lysinibacillus sphaericus, Lysinibacillus sphaericus 9602
Mengin-Lecreulx, D.; van Heijenoort, J.; Park, J.T.
Identification of the mpl gene encoding UDP-N-acetylmuramate:L-alanyl-gamma-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan
J. Bacteriol.
178
5347-5352
1996
Escherichia coli
Banerjee, R.V.; Shane, B.; McGuire, J.J.; Coward, J.K.
Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates
Biochemistry
27
9062-9070
1988
Escherichia coli
le Roux, P.; Auger, G.; van Heijenoort, J.; Blanot, D.
Synthesis of new peptide inhibitors of the meso-diaminopimelate-adding enzyme
Eur. J. Med. Chem.
27
899-907
1992
Escherichia coli
-
Abo-Ghalia, M.; Flegel, M.; Blanot, D.; van Heijenoort, J.
Synthesis of inhibitors of the meso-diaminopimelate-adding enzyme from Escherichia coli
Int. J. Pept. Protein Res.
32
208-222
1988
Escherichia coli
Mengin-Lecreulx, D.; Blanot, D.; van Heijenoort, J.
Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coli
J. Bacteriol.
176
4321-4327
1994
BRENDA: Escherichia coli
Textmining: Chalaropsis
Michaud, C.; Mengin-Lecreulx, D.; van Heijenoort, J.; Blanot, D.
Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase from Escherichia coli
Eur. J. Biochem.
194
853-861
1990
Escherichia coli
Mengin-Lecreulx, D.; Flouret, B.; Van Heijenoort, J.
Cytoplasmic steps of peptidoglycan synthesis in Escherichia coli
J. Bacteriol.
151
1109-1117
1982
Escherichia coli
Reusch, V.M.; Hale, S.G.; Hurly, B.J.
Levels of cell wall enzymes in endospores and vegetative cells of Bacillus subtilis
J. Bacteriol.
152
1147-1153
1982
Bacillus subtilis
Azzolina, B.A.; Yuan, X.; Anderson, M.S.; El-Sherbeini, M.
The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: Cloning, production, and purification of active enzymes
Protein Expr. Purif.
21
393-400
2001
Pseudomonas aeruginosa
Dementin, S.; Bouhss, A.; Auger, G.; Parquet, C.; Mengin-Lecreulx, D.; Dideberg, O.; van Heijenoort, J.; Blanot, D.
Evidence of a functional requirement for a carbamoylated lysine residue in MurD, MurE and MurF synthetases as established by chemical rescue experiments
Eur. J. Biochem.
268
5800-5807
2001
Escherichia coli
Gordon, E.; Flouret, B.; Chantalat, L.; van Heijenoort, J.; Mengin-Lecreulx, D.; Dideberg, O.
Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase from Escherichia coli
J. Biol. Chem.
276
10999-11006
2001
Escherichia coli (P22188)
Ludovice, A.M.; Wu, S.W.; de Lencastre, H.
Molecular cloning and DNA sequencing of the Staphylococcus aureus UDP-N-acetylmuramyl tripeptide synthetase (murE) gene, essential for the optimal expression of methicillin resistance
Microb. Drug Resist.
4
85-90
1998
BRENDA: Staphylococcus aureus
Textmining: insertion sequences
Herve, M.; Boniface, A.; Gobec, S.; Bianot, D.; Mengin-Lecreulx, D.
Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
J. Bacteriol.
189
3987-3995
2007
Escherichia coli
Boniface, A.; Bouhss, A.; Mengin-Lecreulx, D.; Blanot, D.
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity
J. Biol. Chem.
281
15680-15686
2006
Thermotoga maritima
Paradis-Bleau, C.; Beaumont, M.; Boudreault, L.; Lloyd, A.; Sanschagrin, F.; Bugg, T.D.; Levesque, R.C.
Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme
Peptides
27
1693-1700
2006
Pseudomonas aeruginosa, Middle East respiratory syndrome-related coronavirus
Humljan, J.; Kotnik, M.; Boniface, A.; Solmajer, T.; Urleb, U.; Blanot, D.; Gobec, S.
A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE
Tetrahedron
62
10980-10988
2006
Staphylococcus aureus
-
Paradis-Bleau, C.; Lloyd, A.; Sanschagrin, F.; Maaroufi, H.; Clarke, T.; Blewett, A.; Dowson, C.; Roper, D.I.; Bugg, T.D.; Levesque, R.C.
Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor
Biochem. J.
421
263-272
2009
BRENDA: Pseudomonas aeruginosa
Textmining: Escherichia virus M13
Guzman, J.D.; Wube, A.; Evangelopoulos, D.; Gupta, A.; Huefner, A.; Basavannacharya, C.; Rahman, M.M.; Thomaschitz, C.; Bauer, R.; McHugh, T.D.; Nobeli, I.; Prieto, J.M.; Gibbons, S.; Bucar, F.; Bhakta, S.
Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics
J. Antimicrob. Chemother.
66
1766-1772
2011
Mycobacterium tuberculosis
Shanmugam, A.; Natarajan, J.
Comparative modeling of UDP-N-acetylmuramoyl-glycyl-D-glutamate-2,6-diaminopimelate ligase from Mycobacterium leprae and analysis of its binding features through molecular docking studies
J. Mol. Model.
18
115-125
2012
Mycobacterium leprae, Mycobacterium leprae (O69557)
Basavannacharya, C.; Moody, P.R.; Munshi, T.; Cronin, N.; Keep, N.H.; Bhakta, S.
Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis
Protein Cell
1
1011-1022
2010
Mycobacterium tuberculosis
Basavannacharya, C.; Robertson, G.; Munshi, T.; Keep, N.; Bhakta, S.
ATP-dependent MurE ligase in Mycobacterium tuberculosis: Biochemical and structural characterisation
Tuberculosis
90
16-24
2010
Mycobacterium tuberculosis (P9WJL3), Mycobacterium tuberculosis H37Rv (P9WJL3)
Munshi, T.; Gupta, A.; Evangelopoulos, D.; Guzman, J.D.; Gibbons, S.; Keep, N.H.; Bhakta, S.
Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis
PLoS ONE
8
e60143
2013
Mycobacterium tuberculosis (P9WJL3), Mycobacterium tuberculosis H37Rv (P9WJL3)
Blasiak, L.; Clardy, J.
Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression
J. Am. Chem. Soc.
132
926-927
2010
Pseudoalteromonas tunicata
Patin, D.; Turk, S.; Barreteau, H.; Mainardi, J.L.; Arthur, M.; Gobec, S.; Mengin-Lecreulx, D.; Blanot, D.
Unusual substrate specificity of the peptidoglycan MurE ligase from Erysipelothrix rhusiopathiae
Biochimie
121
209-218
2016
Erysipelothrix rhusiopathiae (E7FUC9), Erysipelothrix rhusiopathiae
Paradis-Bleau, C.; Beaumont, M.; Boudreault, L.; Lloyd, A.; Sanschagrin, F.; Bugg, T.D.; Levesque, R.C.
Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme
Peptides
27
1693-1700
2006
Pseudomonas aeruginosa, Middle East respiratory syndrome-related coronavirus
Wang, N; Yang, G; Che, C; Liu, Y
Heterogenous expression of poly-gamma-glutamic acid synthetase complex gene of Bacillus licheniformis WBL-3.
Prikl Biokhim Mikrobiol
47
424-8
0
Bacillus licheniformis, Bacillus subtilis
Michaud, C; Parquet, C; Flouret, B; Blanot, D; van Heijenoort, J
Revised interpretation of the sequence containing the murE gene encoding the UDP-N-acetylmuramyl-tripeptide synthetase of Escherichia coli.
Biochem J
269
277-8
1990
Escherichia coli
Auger, G; van Heijenoort, J; Vederas, JC; Blanot, D
Effect of analogues of diaminopimelic acid on the meso-diaminopimelate-adding enzyme from Escherichia coli.
FEBS Lett
391
171-4
1996
Escherichia coli
Ma, C; Redfield, RJ
Point mutations in a peptidoglycan biosynthesis gene cause competence induction in Haemophilus influenzae.
J Bacteriol
182
3323-30
2000
Haemophilus influenzae
Jana, M; Luong, TT; Komatsuzawa, H; Shigeta, M; Lee, CY
A method for demonstrating gene essentiality in Staphylococcus aureus.
Plasmid
44
100-4
2000
Staphylococcus aureus, Escherichia coli, Bacillus licheniformis, Bacillus subtilis
Bhattacharjee, B; Simon, RM; Gangadharaiah, C; Karunakar, P
Chemogenomics profiling of drug targets of peptidoglycan biosynthesis pathway in Leptospira interrogans by virtual screening approaches.
J Microbiol Biotechnol
23
779-84
2013
Bacteria
Todorova, K; Maurer, P; Rieger, M; Becker, T; Bui, NK; Gray, J; Vollmer, W; Hakenbeck, R
Transfer of penicillin resistance from Streptococcus oralis to Streptococcus pneumoniae identifies murE as resistance determinant.
Mol Microbiol
97
866-80
2015
Streptococcus oralis, Streptococcus pneumoniae, Transformation
Leprohon, P; Gingras, H; Ouennane, S; Moineau, S; Ouellette, M
A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages.
BMC Genomics
16
972
2015
Streptococcus pneumoniae
Ashiuchi, M; Misono, H
Biochemistry and molecular genetics of poly-gamma-glutamate synthesis.
Appl Microbiol Biotechnol
59
9-14
2002
Bacillus subtilis
ink, R; Barreteau, H; Patin, D; Mengin-Lecreulx, D; Gobec, S; Blanot, D
MurD enzymes: some recent developments.
Biomol Concepts
4
539-56
2013
Escherichia coli
Perdih, A; Hrast, M; Pureber, K; Barreteau, H; Grdadolnik, SG; Kocjan, D; Gobec, S; Solmajer, T; Wolber, G
Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC-MurF): experimental and computational characterization.
J Comput Aided Mol Des
29
541-60
2015
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