Information on EC 6.3.1.5 - NAD+ synthase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
6.3.1.5
-
RECOMMENDED NAME
GeneOntology No.
NAD+ synthase
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
NAD biosynthesis I (from aspartate)
-
Nicotinate and nicotinamide metabolism
-
SYSTEMATIC NAME
IUBMB Comments
Deamido-NAD+:ammonia ligase (AMP-forming)
L-Glutamine also acts, more slowly, as amido-donor [cf. EC 6.3.5.1].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ammonia-dependent NADS
-
-
ammonia-dependent nicotinamide adenine dinucleotide synthetase
-
-
ammonia-specific NAD synthase
-
-
ammonia-specific NAD synthetase
E07950
-
ammonia-specific NAD synthetase
Geobacillus stearothermophilus H-804
E07950
-
-
Diphosphopyridine nucleotide synthetase
-
-
-
-
NAD synthase
-
-
NAD synthase
E07950
-
NAD synthase
Geobacillus stearothermophilus H-804
E07950
-
-
NAD synthase
-
-
NAD synthase
-
-
-
NAD synthetase
-
-
-
-
NAD synthetase
-
-
NAD synthetase
E07950
-
NAD synthetase
Geobacillus stearothermophilus H-804
E07950
-
-
NAD synthetase
-
-
NAD synthetase
-
-
NAD synthetase
Staphylococcus aureus 8325-4
-
-
-
NAD synthetase
-
-
NAD synthetase
-
-
-
NAD+ synthetase
-
-
-
-
NAD+ synthetase
-
-
NadE
Staphylococcus aureus 8325-4
-
-
-
NH3-dependent NAD+ synthetase
-
-
NH3-dependent NAD+ synthetase
-
-
Nicotinamide adenine dinucleotide synthetase
-
-
-
-
Nicotinamide adenine dinucleotide synthetase
-
-
Nicotinamide adenine dinucleotide synthetase
-
-
Nicotinamide adenine dinucleotide synthetase
E07950
-
Nicotinamide adenine dinucleotide synthetase
Geobacillus stearothermophilus H-804
E07950
-
-
Nicotinamide adenine dinucleotide synthetase
-
-
Nicotinamide adenine dinucleotide synthetase
-
-
Nicotinamide adenine dinucleotide synthetase
-
-
-
Qns1
-
couples a glutamine amidotransferase domain to a second active site that requires ammonia as a reactant
Synthetase, nicotinamide adenine dinucleotide
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9032-69-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
purified recombinant enzyme
Uniprot
Manually annotated by BRENDA team
wild-type and mutant enzyme
-
-
Manually annotated by BRENDA team
strain B
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
H-804
E07950
GenBank
Manually annotated by BRENDA team
Geobacillus stearothermophilus H-804
H-804
E07950
GenBank
Manually annotated by BRENDA team
strain LT2, wild-type and mutant strains which are defective in NAD synthetase
-
-
Manually annotated by BRENDA team
strain 8325-4
-
-
Manually annotated by BRENDA team
Staphylococcus aureus 8325-4
strain 8325-4
-
-
Manually annotated by BRENDA team
strain 6715
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-, Q2A4B6
existence of an alternative route of NAD synthesis where the amidation of NaMN to nicotinamide mononucleotide occurs before the adenylylation reaction, which converts the intermediate to the NAD cofactor. The first step is catalyzed by Francisella tularensis NadE
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.25
-
deamido-NAD+
-, Q2A4B6
-
0.5
-
deamido-NMN
-, Q2A4B6
-
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8.2
8.7
-, Q81RP3
-
additional information
-
-
active in a broad pH range
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.3
-
E07950, -
isoelectric focusing
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Burkholderia pseudomallei (strain 1710b)
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Francisella tularensis subsp. holarctica (strain LVS)
Helicobacter pylori (strain ATCC 700392 / 26695)
Helicobacter pylori (strain ATCC 700392 / 26695)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Vibrio cholerae serotype O1 (strain MJ-1236)
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
50000
-
E07950, -
gel filtration