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Information on EC 6.2.1.5 - succinate-CoA ligase (ADP-forming) and Organism(s) Rattus norvegicus

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.5 succinate-CoA ligase (ADP-forming)
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This record set is specific for:
Rattus norvegicus
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
sucla2, succd, a-scs, cg11963, scact, adp-forming succinyl-coa synthetase, scs-betaa, a-stk, succinyl-coa synthetase (adp-forming), succinyl-coa ligase (atp-forming), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A-SCS
-
-
-
-
A-STK
-
-
-
-
SCS-alpha
-
-
-
-
SCS-beta
-
-
-
-
SCS-betaA
-
-
-
-
STK
-
-
-
-
Succinate thiokinase
-
-
-
-
Succinic thiokinase
-
-
-
-
Succinyl coenzyme A synthetase
-
-
-
-
Succinyl coenzyme A synthetase (adenosine diphosphate-forming)
-
-
-
-
Succinyl-CoA synthetase
-
-
-
-
Succinyl-CoA synthetase (ADP-forming)
-
-
-
-
Synthetase, succinyl coenzyme A (adenosine diphosphate-forming)
-
-
-
-
VEG239
-
-
-
-
VEG63
-
-
-
-
Vegetative protein 239
-
-
-
-
Vegetative protein 63
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinate:CoA ligase (ADP-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9080-33-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
show the reaction diagram
-
generation of ATP is critical for the beta-cell mitochondrial metabolism
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
show the reaction diagram
-
generation of ATP is critical for the beta-cell mitochondrial metabolism
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.017 - 1.6
ATP
0.056
CoA
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
two distinct ATP-specific and GTP-specific succinyl-CoA synthetases
Manually annotated by BRENDA team
-
two distinct ATP-specific and GTP-specific succinyl-CoA synthetases
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUCA_RAT
346
1
36148
Swiss-Prot
Mitochondrion (Reliability: 3)
A0A8I6A4L2_RAT
361
0
37498
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I6AQ32_RAT
323
0
34237
TrEMBL
other Location (Reliability: 4)
A0A0H2UHE1_RAT
360
0
37560
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I6A1U8_RAT
458
0
49396
TrEMBL
Mitochondrion (Reliability: 1)
F1LM47_RAT
465
0
50306
TrEMBL
Mitochondrion (Reliability: 1)
A0A8I6AAD9_RAT
328
0
34419
TrEMBL
Secretory Pathway (Reliability: 4)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
the alpha-subunit of succinyl-CoA synthetase undergoes autophosphorylation at a histidine residue. Coprovision of exogenous succinate and CoA results in pronounced dephosphorylation of the phosphorylated alpha-subunit of succinyl-CoA synthetase
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Krivanek, J.; Novakova, L.
A novel effect of vanadium ions: inhibition of succinyl-CoA synthetase
Gen. Physiol. Biophys.
10
71-82
1991
Rattus norvegicus
Manually annotated by BRENDA team
Krivanek, J.; Novakova, L.
Differential sensitivity of the brain ATP-dependent and GTP-dependent succinyl-CoA synthetase to vanadium ions. Developmental aspects
Physiol. Res.
41
345-350
1992
Rattus norvegicus
Manually annotated by BRENDA team
Kowluru, A.
Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion
Diabetologia
44
89-94
2001
Rattus norvegicus
Manually annotated by BRENDA team