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Information on EC 6.2.1.5 - succinate-CoA ligase (ADP-forming) and Organism(s) Drosophila melanogaster

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.5 succinate-CoA ligase (ADP-forming)
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
sucla2, succd, a-scs, cg11963, scact, adp-forming succinyl-coa synthetase, scs-betaa, a-stk, succinyl-coa synthetase (adp-forming), succinyl-coa ligase (atp-forming), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A-SCS
-
-
-
-
A-STK
-
-
-
-
SCS-alpha
-
-
-
-
SCS-beta
-
-
-
-
SCS-betaA
-
-
-
-
STK
-
-
-
-
Succinate thiokinase
-
-
-
-
Succinic thiokinase
-
-
-
-
Succinyl coenzyme A synthetase
-
-
-
-
Succinyl coenzyme A synthetase (adenosine diphosphate-forming)
-
-
-
-
Succinyl-CoA synthetase
Succinyl-CoA synthetase (ADP-forming)
-
-
-
-
Synthetase, succinyl coenzyme A (adenosine diphosphate-forming)
-
-
-
-
VEG239
-
-
-
-
VEG63
-
-
-
-
Vegetative protein 239
-
-
-
-
Vegetative protein 63
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinate:CoA ligase (ADP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9080-33-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
a Drosophila orthologue of succinyl-CoA synthetase beta-subunit is a modulator of Drosophila KCNQ channels responsible for slowly activating potassium currents in heart, brain, and other tissues, direct interaction with the intracellular C-terminal tail KCNQ channel, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
a Drosophila orthologue of succinyl-CoA synthetase beta-subunit is a modulator of Drosophila KCNQ channels responsible for slowly activating potassium currents in heart, brain, and other tissues, direct interaction with the intracellular C-terminal tail KCNQ channel, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene CG11963
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUCA_DROME
328
0
34389
Swiss-Prot
Mitochondrion (Reliability: 4)
A0AMM0_DROME
342
0
35889
TrEMBL
Mitochondrion (Reliability: 3)
A0A126GUR6_DROME
452
0
49087
TrEMBL
other Location (Reliability: 4)
Q9VDW7_DROME
342
0
35871
TrEMBL
Mitochondrion (Reliability: 3)
Q95U38_DROME
503
0
54911
TrEMBL
other Location (Reliability: 4)
A0A0B4JCW4_DROME
451
0
48984
TrEMBL
other Location (Reliability: 4)
Q9VHJ8_DROME
502
0
54808
TrEMBL
other Location (Reliability: 4)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene CG11963, expression as GST-tagged enzyme in Escherichia coli strain BL21(DE3), interaction analysis of Myc-tagged CG11963 and FLAG-tagged dKCNQ using the yeast two-hybrid system
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gao, L.; Fei, H.; Connors, N.C.; Zhang, J.; Levitan, I.B.
Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels
J. Neurophysiol.
99
2736-2740
2008
Drosophila melanogaster
Manually annotated by BRENDA team