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ATP + 1-naphthoate + CoA
AMP + diphosphate + 1-naphthoyl-CoA
-
kcat/Km is 0.6% compared to the wild-type value
-
-
?
ATP + 2,7-dihydroxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2,7-dihydroxy-5-methyl-1-naphthoyl-CoA
ATP + 2,7-dihydroxy-5-methylnaphthalene-1-carboxylic acid + CoA
AMP + diphosphate + ?
-
47% activity compared to 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
?
ATP + 2-hydroxy-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-1-naphthoyl-CoA
ATP + 2-hydroxy-5,7-dimethoxy-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-5,7-dimethoxy-1-naphthoyl-CoA
-
kcat/Km is 35% compared to the wild-type value
-
-
?
ATP + 2-hydroxy-5,7-dimethoxynaphthalene-1-carboxylic acid + CoA
AMP + diphosphate + ?
-
35% activity compared to 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
?
ATP + 2-hydroxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-5-methyl-1-naphthoyl-CoA
-
kcat/Km is 50% compared to the wild-type value
-
-
?
ATP + 2-hydroxy-5-methylnaphthalene-1-carboxylic acid + CoA
AMP + diphosphate + ?
-
50% activity compared to 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
?
ATP + 2-hydroxy-7-methoxy-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-1-naphthoyl-CoA
-
kcat/Km is 5% compared to the wild-type value
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
ATP + 2-hydroxy-7-methoxynaphthalene-1-carboxylic acid + CoA
AMP + diphosphate + ?
-
4.8% activity compared to 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
?
ATP + 2-hydroxynaphthalene-1-carboxylic acid + CoA
AMP + diphosphate + ?
-
1.3% activity compared to 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
?
ATP + naphthalene-1-carboxylic acid + CoA
AMP + diphosphate + ?
-
0.58% activity compared to 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
?
ATP + 2,7-dihydroxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2,7-dihydroxy-5-methyl-1-naphthoyl-CoA
-
kcat/Km is 47% compared to the wild-type value
-
-
?
ATP + 2,7-dihydroxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2,7-dihydroxy-5-methyl-1-naphthoyl-CoA
-
kcat/Km is 47% compared to the wild-type value
-
-
?
ATP + 2-hydroxy-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-1-naphthoyl-CoA
-
kcat/Km is 1.3% compared to the wild-type value
-
-
?
ATP + 2-hydroxy-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-1-naphthoyl-CoA
-
kcat/Km is 1.3% compared to the wild-type value
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
-
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
100% activity
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
the enzyme is involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
-
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
100% activity
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
the enzyme is involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin
-
-
?
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ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
100% activity
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
the enzyme is involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
100% activity
-
-
?
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA
AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
-
the enzyme is involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin
-
-
?
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0.018
1-naphthoate
-
pH 8.0, 24°C
0.0031
2,7-dihydroxy-5-methyl-1-naphthoate
-
pH 8.0, 24°C
0.0031
2,7-dihydroxy-5-methylnaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.0034
2-hydroxy-1-naphthoate
-
pH 8.0, 24°C
0.0011
2-hydroxy-5,7-dimethoxy-1-naphthoate
-
pH 8.0, 24°C
0.0011
2-hydroxy-5,7-dimethoxynaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.00025
2-hydroxy-5-methyl-1-naphthoate
-
pH 8.0, 24°C
0.00025
2-hydroxy-5-methylnaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.0023
2-hydroxy-7-methoxy-1-naphthoate
-
pH 8.0, 24°C
0.00059
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
0.0023
2-hydroxy-7-methoxynaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.0034
2-hydroxynaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.018
Naphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.00059
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
pH 8.0, 24°C
0.00059
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
pH and temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.11
1-naphthoate
-
pH 8.0, 24°C
1.55
2,7-dihydroxy-5-methyl-1-naphthoate
-
pH 8.0, 24°C
1.55
2,7-dihydroxy-5-methylnaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.047
2-hydroxy-1-naphthoate
-
pH 8.0, 24°C
0.42
2-hydroxy-5,7-dimethoxy-1-naphthoate
-
pH 8.0, 24°C
0.42
2-hydroxy-5,7-dimethoxynaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.135
2-hydroxy-5-methyl-1-naphthoate
-
pH 8.0, 24°C
0.135
2-hydroxy-5-methylnaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.118
2-hydroxy-7-methoxy-1-naphthoate
-
pH 8.0, 24°C
0.63
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
0.12
2-hydroxy-7-methoxynaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.05
2-hydroxynaphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.11
Naphthalene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.63
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
pH and temperature not specified in the publication
0.63
2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
pH 8.0, 24°C
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Cooke, H.A.; Zhang, J.; Griffin, M.A.; Nonaka, K.; van Lanen, S.G.; Shen, B.; Bruner, S.D.
Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin
J. Am. Chem. Soc.
129
7728-7729
2007
Streptomyces carzinostaticus, Streptomyces carzinostaticus ATCC 15944
brenda