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Information on EC 6.2.1.4 - succinate-CoA ligase (GDP-forming) and Organism(s) Rattus norvegicus

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.4 succinate-CoA ligase (GDP-forming)
IUBMB Comments
Itaconate can act instead of succinate, and ITP instead of GTP.
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This record set is specific for:
Rattus norvegicus
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
succinyl-coa synthetase, suclg1, suclg2, succinate-coa ligase, succinate thiokinase, succinyl coa synthetase, succinyl-coa synthase, succinic thiokinase, succinyl coenzyme a synthetase, g-scs, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G-STK
-
-
-
-
SCS-alpha
-
-
-
-
SCS-beta
-
-
-
-
SCS-betaG
-
-
-
-
Succinate thiokinase
-
-
-
-
Succinic thiokinase
-
-
-
-
Succinyl CoA synthetase
-
-
-
-
Succinyl coenzyme A synthetase
-
-
-
-
Succinyl coenzyme A synthetase (GDP-forming)
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-
-
-
Succinyl coenzyme A synthetase (guanosine diphosphate-forming)
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-
-
-
Succinyl-CoA synthetase
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Succinyl-CoA synthetase (GDP-forming)
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-
-
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Synthetase, succinyl coenzyme A (guanosine diphosphate-forming)
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinate:CoA ligase (GDP-forming)
Itaconate can act instead of succinate, and ITP instead of GTP.
CAS REGISTRY NUMBER
COMMENTARY hide
9014-36-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP + phosphate + succinyl-CoA
GTP + succinate + CoA
show the reaction diagram
-
GTP generated by the activation of succinyl-CoA synthetase could promote key functional roles in the mitochondrial metabolism leading to insulin secretion
-
?
GTP + succinate + CoA
?
show the reaction diagram
-
production of succinyl-CoA for ketone body metabolism and as a precursor for porphyrins
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
show the reaction diagram
additional information
?
-
-
the enzyme supports GTP-dependent anabolic processes
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP + phosphate + succinyl-CoA
GTP + succinate + CoA
show the reaction diagram
-
GTP generated by the activation of succinyl-CoA synthetase could promote key functional roles in the mitochondrial metabolism leading to insulin secretion
-
?
GTP + succinate + CoA
?
show the reaction diagram
-
production of succinyl-CoA for ketone body metabolism and as a precursor for porphyrins
-
-
?
additional information
?
-
-
the enzyme supports GTP-dependent anabolic processes
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
two distinct ATP-specific and GTP-specific succinyl-CoA synthetases
Manually annotated by BRENDA team
-
two distinct ATP-specific and GTP-specific succinyl-CoA synthetases
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUCA_RAT
346
1
36148
Swiss-Prot
Mitochondrion (Reliability: 3)
B1H270_RAT
434
0
46988
TrEMBL
Mitochondrion (Reliability: 1)
F1LPV8_RAT
425
0
46127
TrEMBL
Mitochondrion (Reliability: 1)
A0A8I6A4L2_RAT
361
0
37498
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I6AQ32_RAT
323
0
34237
TrEMBL
other Location (Reliability: 4)
A0A0H2UHE1_RAT
360
0
37560
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I5ZV34_RAT
401
0
43568
TrEMBL
Mitochondrion (Reliability: 1)
A0A8I6AHY6_RAT
424
0
46109
TrEMBL
Mitochondrion (Reliability: 1)
A0A8I6AIH6_RAT
438
0
47687
TrEMBL
Mitochondrion (Reliability: 1)
A0A8I6AAD9_RAT
328
0
34419
TrEMBL
Secretory Pathway (Reliability: 4)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
precursor of alpha-subunit 31630, calculation from nucleotide sequence
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
the alpha-subunit of succinyl-CoA synthetase undergoes autophosphorylation at a histidine residue. Coprovision of exogenous succinate and CoA results in pronounced dephosphorylation of the phosphorylated alpha-subunit of succinyl-CoA synthetase
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
48
-
10 min, about 40% loss of activity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cytoplasmic precursor of the alpha-subunit, amino acid sequence of the alpha subunit shows an extraordinary degree of homology to the alpha subunbit of Escherichia coli succinyl-CoA synthetase, with more than 70% of the residues identical
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Henning, W.D.; Upton, C.; McFadden, G.; Majumdar, R.; Bridger, W.A.
Cloning and sequencing of the cytoplasmic precursor to the alpha subunit of rat liver mitochondrial succinyl-CoA synthetase
Proc. Natl. Acad. Sci. USA
85
1432-1436
1988
Rattus norvegicus
Manually annotated by BRENDA team
Jenkins, T.M.; Weitzman, P.D.J.
Distinct physiological roles of animal succinate thiokinases: Association of guanine nucleotide-linked succinate thiokinase with ketone body utilization
FEBS Lett.
205
215-218
1986
Rattus norvegicus
Manually annotated by BRENDA team
Weitzman, P.D.J.; Jenkins, T.; Else, A.J.; Holt, R.A.
Occurrence of two distinct succinate thiokinases in animal tissues
FEBS Lett.
199
57-60
1986
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Kowluru, A.
Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion
Diabetologia
44
89-94
2001
Rattus norvegicus
Manually annotated by BRENDA team
Lambeth, D.O.; Tews, K.N.; Adkins, S.; Frohlich, D.; Milavetz, B.I.
Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues
J. Biol. Chem.
279
36621-36624
2004
Rattus norvegicus
Manually annotated by BRENDA team
Kibbey, R.G.; Pongratz, R.L.; Romanelli, A.J.; Wollheim, C.B.; Cline, G.W.; Shulman, G.I.
Mitochondrial GTP regulates glucose-stimulated insulin secretion
Cell Metab.
5
253-264
2007
Rattus norvegicus
Manually annotated by BRENDA team