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Information on EC 6.2.1.4 - succinate-CoA ligase (GDP-forming) and Organism(s) Dictyostelium discoideum

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     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.4 succinate-CoA ligase (GDP-forming)
IUBMB Comments
Itaconate can act instead of succinate, and ITP instead of GTP.
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This record set is specific for:
Dictyostelium discoideum
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
succinyl-coa synthetase, suclg1, suclg2, succinate-coa ligase, succinate thiokinase, succinyl coa synthetase, succinic thiokinase, succinyl-coa synthase, succinyl coenzyme a synthetase, g-scs, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G-STK
-
-
-
-
SCS
-
-
-
-
SCS-alpha
-
-
-
-
SCS-beta
-
-
-
-
SCS-betaG
-
-
-
-
Succinate thiokinase
-
-
-
-
Succinic thiokinase
-
-
-
-
Succinyl CoA synthetase
-
-
-
-
Succinyl coenzyme A synthetase
-
-
-
-
Succinyl coenzyme A synthetase (GDP-forming)
-
-
-
-
Succinyl coenzyme A synthetase (guanosine diphosphate-forming)
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-
-
-
Succinyl-CoA synthetase (GDP-forming)
-
-
-
-
Synthetase, succinyl coenzyme A (guanosine diphosphate-forming)
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinate:CoA ligase (GDP-forming)
Itaconate can act instead of succinate, and ITP instead of GTP.
CAS REGISTRY NUMBER
COMMENTARY hide
9014-36-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
show the reaction diagram
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-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUCA_DICDI
315
0
33174
Swiss-Prot
Mitochondrion (Reliability: 3)
SUCB2_DICDI
420
0
45664
Swiss-Prot
other Location (Reliability: 4)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
p36, i.e. alpha-subunit of succinyl-CoA synthetase
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alpha-subunit, the deduced amino acid sequence shows 75% identity to that of rat liver, which represents a GTP-utilizing form of SCS, and 62% identity to the Escherichia coli protein, which is an ATP-utilizing form
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Um, H.D.; Klein, C.
Evidence for allosteric regulation of succinyl-CoA synthetase
Biochem. J.
295
821-826
1993
Dictyostelium discoideum
Manually annotated by BRENDA team
Anschutz, A.L.; Um, H.D.; Siegel, N.R.; Veron, M.; Klein, C.
P36, a Dictyostelium discoideum protein whose phosphorylation is stimulated by GDP, is homologous to the alpha-subunit of succinyl-CoA synthetase
Biochim. Biophys. Acta
1162
40-46
1993
Dictyostelium discoideum
Manually annotated by BRENDA team
Um H.D.; Klein, C.
Regulatory role of GDP in the phosphoenzyme formation of guanine nucleotide: specific form of succinyl coenzyme A synthetase
J. Protein Chem.
13
177-185
1994
Dictyostelium discoideum, Sus scrofa
Manually annotated by BRENDA team
Birney, M.A.; Klein, C.
Cloning and expression of the alpha subunit of succinyl-CoA synthetase from Dictyostelium discoideum
Arch. Biochem. Biophys.
319
93-101
1995
Dictyostelium discoideum
Manually annotated by BRENDA team