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Information on EC 6.2.1.4 - succinate-CoA ligase (GDP-forming) and Organism(s) Bos taurus

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.4 succinate-CoA ligase (GDP-forming)
IUBMB Comments
Itaconate can act instead of succinate, and ITP instead of GTP.
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This record set is specific for:
Bos taurus
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The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
succinyl-coa synthetase, suclg1, suclg2, succinate-coa ligase, succinate thiokinase, succinyl coa synthetase, succinic thiokinase, succinyl-coa synthase, g-scs, succinyl coenzyme a synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G-STK
-
-
-
-
SCS
-
-
-
-
SCS-alpha
-
-
-
-
SCS-beta
-
-
-
-
SCS-betaG
-
-
-
-
Succinate thiokinase
-
-
-
-
Succinic thiokinase
-
-
-
-
Succinyl CoA synthetase
-
-
-
-
Succinyl coenzyme A synthetase
-
-
-
-
Succinyl coenzyme A synthetase (GDP-forming)
-
-
-
-
Succinyl coenzyme A synthetase (guanosine diphosphate-forming)
-
-
-
-
Succinyl-CoA synthetase (GDP-forming)
-
-
-
-
Synthetase, succinyl coenzyme A (guanosine diphosphate-forming)
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinate:CoA ligase (GDP-forming)
Itaconate can act instead of succinate, and ITP instead of GTP.
CAS REGISTRY NUMBER
COMMENTARY hide
9014-36-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + succinate + CoA
?
show the reaction diagram
-
recycling of succinate to succinyl-CoA at the expense of GTP, involvement in heme biosynthesis
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + succinate + CoA
?
show the reaction diagram
-
recycling of succinate to succinyl-CoA at the expense of GTP, involvement in heme biosynthesis
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ADP
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUCA_BOVIN
346
0
36167
Swiss-Prot
Mitochondrion (Reliability: 1)
SUCB2_BOVIN
432
0
46691
Swiss-Prot
Mitochondrion (Reliability: 2)
F1MZ38_BOVIN
346
0
36139
TrEMBL
Mitochondrion (Reliability: 1)
A0A3Q1N238_BOVIN
334
0
34986
TrEMBL
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jenkins, T.M.; Weitzman, P.D.J.
Physiological role of animal succinate thiokinase
FEBS Lett.
230
6-8
1988
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Weitzman, P.D.J.; Jenkins, T.; Else, A.J.; Holt, R.A.
Occurrence of two distinct succinate thiokinases in animal tissues
FEBS Lett.
199
57-60
1986
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team