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Information on EC 6.2.1.2 - medium-chain acyl-CoA ligase and Organism(s) Homo sapiens

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.2 medium-chain acyl-CoA ligase
IUBMB Comments
Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
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Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
elongase, macs2, mig protein, medium chain acyl-coa synthetase, butyryl-coa synthetase, xm-ligase, short-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid:coa ligase, medium chain acyl-coenzyme a synthetase, butyryl-coenzyme a synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl-activating enzyme
-
-
-
-
butanoate:CoA ligase (AMP-forming)
-
-
-
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butyrate-CoA ligase
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-
-
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Butyryl-CoA synthetase
-
-
-
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Butyryl-coenzyme A synthetase
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-
-
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Fatty acid thiokinase (medium chain)
-
-
-
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L-(+)-3-Hydroxybutyryl CoA ligase
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-
-
-
MACS2
-
-
Medium chain acyl-coenzyme A synthetase
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-
-
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medium-chain acyl-CoA synthetase 2
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Short-chain acyl-CoA synthetase
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-
-
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Synthetase, butyryl conzyme A
-
-
-
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xenobiotic/medium-chain fatty acid:CoA ligase
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-
XM-ligase
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
medium-chain fatty acid:CoA ligase (AMP-forming)
Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
CAS REGISTRY NUMBER
COMMENTARY hide
9080-51-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
show the reaction diagram
-
-
-
?
ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACS2A_HUMAN
577
0
64223
Swiss-Prot
Mitochondrion (Reliability: 2)
ACS2B_HUMAN
577
0
64271
Swiss-Prot
Mitochondrion (Reliability: 2)
ACSL3_HUMAN
720
1
80420
Swiss-Prot
Secretory Pathway (Reliability: 3)
ACSM4_HUMAN
580
0
65703
Swiss-Prot
Mitochondrion (Reliability: 2)
ACSM5_HUMAN
579
0
64760
Swiss-Prot
Mitochondrion (Reliability: 1)
ACSM6_HUMAN
480
0
53585
Swiss-Prot
Mitochondrion (Reliability: 3)
ACSM1_HUMAN
577
0
65273
Swiss-Prot
Mitochondrion (Reliability: 2)
ACSM3_HUMAN
586
0
66153
Swiss-Prot
Mitochondrion (Reliability: 1)
ACSF2_HUMAN
615
0
68125
Swiss-Prot
Mitochondrion (Reliability: 1)
A0A2Z4T009_HUMAN
40
0
4482
TrEMBL
other Location (Reliability: 1)
A0A2Z4SXE8_HUMAN
25
0
2682
TrEMBL
other Location (Reliability: 1)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
enzyme form HXM-A and HXM-B
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of HXM-A in COS cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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involvement of the MACS2 Leu513Ser polymorphism in the development of the metabolic syndrome
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vessey, D.A.; Lau, E.; Kelley, M.; Warren, R.S.
Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria
J. Biochem. Mol. Toxicol.
17
1-6
2003
Homo sapiens
Manually annotated by BRENDA team
Lindner, I.; Rubin, D.; Helwig, U.; Nitz, I.; Hampe, J.; Schreiber, S.; Schrezenmeir, J.; Doering, F.
The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population
Mol. Nutr. Food Res.
50
270-274
2006
Homo sapiens
Manually annotated by BRENDA team