Information on EC 6.2.1.1 - acetate-CoA ligase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
6.2.1.1
-
RECOMMENDED NAME
GeneOntology No.
acetate-CoA ligase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acid-thiol ligation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
acetate conversion to acetyl-CoA
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Biosynthesis of secondary metabolites
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Carbon fixation pathways in prokaryotes
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chitin degradation to ethanol
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cis-genanyl-CoA degradation
-
ethanol degradation II
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ethanol degradation III (oxidative)
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ethanol degradation IV
-
glutamate degradation VII (to butanoate)
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Glycolysis / Gluconeogenesis
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Metabolic pathways
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Methane metabolism
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Microbial metabolism in diverse environments
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Propanoate metabolism
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Pyruvate metabolism
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SYSTEMATIC NAME
IUBMB Comments
acetate:CoA ligase (AMP-forming)
Also acts on propanoate and propenoate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ACAS
-
-
AceCS
-
-
-
-
AceCS1
-
-
AceCS1
-
liver enzyme, 45.8% amino acid identity between AceCS1 and AceCS2
AceCS2
Q9NUB1
-
AceCS2
-
-
AceCS2
Q99NB1
heart enzyme, 45.8% amino acid identity between AceCS1 and AceCS2
Acetate thiokinase
-
-
-
-
Acetate--CoA ligase
-
-
-
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acetate:CoA ligase (AMP-forming)
-
-
acetate:CoA ligase (AMP-forming)
Q2XNL6
-
Acetic thiokinase
-
-
-
-
Acetyl activating enzyme
-
-
-
-
Acetyl CoA ligase
-
-
-
-
Acetyl CoA synthase
-
-
-
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acetyl coenzyme A synthase/carbon monoxide dehydrogenase
-
-
Acetyl coenzyme A synthetase
-
-
-
-
Acetyl coenzyme A synthetase
-
-
Acetyl coenzyme A synthetase
Aliivibrio fischeri ES114
-
-
-
Acetyl coenzyme A synthetase
-
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Acetyl-CoA synthase
-
-
-
-
Acetyl-CoA synthase
-
-
Acetyl-CoA synthetase
-
-
-
-
Acetyl-CoA synthetase
-
-
Acetyl-CoA synthetase
Aliivibrio fischeri ES114
-
-
-
Acetyl-CoA synthetase
Q9LTG4
-
Acetyl-CoA synthetase
-
-
Acetyl-CoA synthetase
-
-
Acetyl-CoA synthetase
-
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acetyl-CoA synthetase 2
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Acetyl-coenzyme A synthase
-
-
-
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Acetyl-coenzyme A synthase
-
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acetyl-coenzyme A synthase/carbon monoxide dehydrogenase
-
-
acetyl-coenzyme A synthetase
Q9LTG4
-
acetyl-coenzyme A synthetase
-
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ACS
-
-
-
-
ACS
Q9NR19
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Acyl-activating enzyme
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-
-
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adenosine monophosphate-forming acetyl-CoA synthetase
-
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adenosine monophosphate-forming acetyl-CoA synthetase
Q2XNL6
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ADP-forming acetyl-CoA synthetase
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-
AMP-forming acetyl-CoA synthetase
-
-
AMP-forming acetyl-CoA synthetase
-
-
AMP-forming acetyl-CoA synthetase
Q2XNL6
-
carbon monoxide dehydrogenase/acety-coenzyme A synthase
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bifunctional enzyme
carbon monoxide dehydrogenase/acetyl-CoA synthase
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-
MT-ACS1
Methanothermobacter thermautotrophicus Z245
-
-
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Short chain fatty acyl-CoA synthetase
-
-
-
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Short-chain acyl-coenzyme A synthetase
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-
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Synthetase, acetyl coenzyme A
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-
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CODH/ACS
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bifunctional enzyme
additional information
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acetyl-CoA synthase is a subunit of the bifunctional CO dehydrogenase/acetyl-CoA synthase, CODH/ACS, complex
additional information
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ACD belongs to the protein superfamily of nucleoside diphosphate-forming acyl-CoA synthetases
additional information
-
acetyl-CoA synthetase belongs to the superfamily of adenylate-forming enzymes, whose three-dimensional structures are analogous to one another
additional information
-
Acs is a member of the broadly distributed AMP-forming acyl-CoA synthetase family of enzymes
CAS REGISTRY NUMBER
COMMENTARY
9012-31-1
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain ATCC 8554
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-
Manually annotated by BRENDA team
strain ES114, gene acs
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-
Manually annotated by BRENDA team
Aliivibrio fischeri ES114
strain ES114, gene acs
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-
Manually annotated by BRENDA team
Amaranthus sp.
-
-
-
Manually annotated by BRENDA team
gene acs1
Q9LTG4
UniProt
Manually annotated by BRENDA team
gene acsA
-
-
Manually annotated by BRENDA team
-
Swissprot
Manually annotated by BRENDA team
several strains, overview
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-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
acetyl-coenzyme A synthetase 2-like, mitochondrial. Precursor
SwissProt
Manually annotated by BRENDA team
patients with hepatocellular carcinoma
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-
Manually annotated by BRENDA team
specific activity of the enzyme is high in cells grown with limited H2 and CO2 supply. It is low in exponentially grown cells
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-
Manually annotated by BRENDA team
Methanothermobacter thermautotrophicus Z245
strain Z245
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-
Manually annotated by BRENDA team
formerly Clostridium thermoaceticum strain ATCC 39073
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
pea
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-
Manually annotated by BRENDA team
strain U
Uniprot
Manually annotated by BRENDA team
genes acdIa and acdIb encoding the alpha and beta subunits
-
-
Manually annotated by BRENDA team
Roseovarius sp.
strain 217
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-
Manually annotated by BRENDA team
strain 217
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-
Manually annotated by BRENDA team
2 enzyme forms Acs1p and Acs2p. Under anaerobic glucose-limited conditions only the ACS2 gene is expressed. During carbon-limited growth on glucose, ethanol, and acetate under aerobic conditions both the ACS1 gene and the ACS2 gene are expressed
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-
Manually annotated by BRENDA team
different isoenzymes are elaborated under aerobic and nonaerobic conditions
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-
Manually annotated by BRENDA team
different isoenzymes are elaborated under aerobic and nonaerobic conditions; strain LK2G12
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-
Manually annotated by BRENDA team
strain LK2G12
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-
Manually annotated by BRENDA team
strain LK2G12; two immunologically distinct enzyme forms are elaborated under aerobic and under nonaerobic conditions
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae LK2G12
strain LK2G12
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-
Manually annotated by BRENDA team
gene acs, different strains
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-
Manually annotated by BRENDA team
Taxus sp.
-
-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
20
50
-
20C: about 45% of maximal activity, 50C: about 30% of maximal activity
45
75
Q2XNL6
45C: about 55% of maximal activity, 75C: about 50% of maximal activity
45
85
-
45C: about 55% of maximal activity, 85C: about 60% of maximal activity, AF-ACS2
PDB
SCOP
CATH
ORGANISM
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
60
-
-
5 min, 20% loss of activity
90
-
-
120 min, stable
98
-
-
half-life: 72 min
100
-
-
half-life: 8 min. Addition of 1 M (NH4)2SO4 stabilizes the enzyme to a half-life of 24 min
OXIDATION STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
the enzyme is O2-sensitive
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687824
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression of CO dehydrogenase/acetyl coenzyme A synthase in Methanosarcina spp. is coordinately regulated in response to substrate by differential transcription initiation and early elongation termination near the 3' end of a 371-bp leader sequence
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