Information on EC 5.99.1.3 - DNA topoisomerase (ATP-hydrolysing)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
5.99.1.3
-
RECOMMENDED NAME
GeneOntology No.
DNA topoisomerase (ATP-hydrolysing)
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
isomerization
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
DNA topoisomerase (ATP-hydrolysing)
The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase).
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
DNA gyrase
-
-
-
-
DNA gyrase
-
-
DNA gyrase
Escherichia coli K-12 RFM443
-
-
-
DNA gyrase
Pseudomonas aeruginosa AC1679-1682, Pseudomonas aeruginosa PAO
-
-
-
DNA gyrase
P66937, Q99XG5
-
DNA gyrase
Staphylococcus aureus CiproS
-
-
-
DNA Top IIbeta
-
-
DNA Topo II
-
-
DNA topo IIalpha
-
-
DNA topoisomerase II
-
-
-
-
DNA topoisomerase II
-, Q7M3G2
-
DNA topoisomerase II
-
-
DNA topoisomerase II
-
-
DNA topoisomerase II
-
-
DNA topoisomerase II alpha
-
-
DNA topoisomerase II beta
-
-
DNA topoisomerase IIalpha
-
-
DNA topoisomerase IIbeta
-
-
DNA topoisomerase IIbeta
-
-
DNA topoisomerase IV
-
type IIA DNA topoisomerase
DNA topoisomerase type II
-
-
-
-
DNA topoisomerase VI
-
-
DNA topoisomerase VI
O05208 and O05207
-
DNA topoisomerases II
-
-
DNA-topoisomerase II
-
-
GyrA
Escherichia coli K-12 RFM443
-
-
-
GyrA
P66937, Q99XG5
-
hTopoIIalpha
P11388
-
NP170 proteins
-
-
-
-
Nuclear proteins 170,000-mol.wt.
-
-
-
-
Protein Gp39
-
-
-
-
Protein Gp52
-
-
-
-
Protein Gp60
-
-
-
-
Proteins , NP170 (specific proteins and subclasses nuclear protein, 170,000-mol.-wt.)
-
-
-
-
PsTopII
-
-
-
-
top2a
-
-
top2a
Danio rerio AB
-
-
-
Top2b
-
-
Top2b
Danio rerio TL/WIK
-
-
-
topIIalpha
-
-
topo II
Q9XZN0
-
topo II
Leishmania donovani MHOM/80/IN/Dd8
Q9XZN0
-
-
topo II alpha
-
-
Topo IIalpha
-
isoform
Topo IIalpha
-
isozyme
Topo IIalpha
-
isoform
Topo IIbeta
-
-
Topo IIbeta
-
isoform
Topo IIbeta
-
isozyme
Topo IIbeta
-
isoform
Topo IIbeta
-
-
topo IV
-
-
topo-IIalpha
-
-
topo2alpha
P11388
-
TOPOII
-
-
-
-
topoIIalpha
-
-
topoIIalpha
-
isozyme
topoIIalpha
-
-
topoIIbeta
-
-
topoIIbeta
-
isozyme
topoIIbeta
-
-
topoisomerase 2 alpha
-
-
Topoisomerase II
-
-
-
-
Topoisomerase II
Chlorella virus Marburg
-
-
Topoisomerase II
-
-
Topoisomerase II
-
-
Topoisomerase II
-
-
Topoisomerase II
-
-
Topoisomerase II
-
-
Topoisomerase II
Q9XZN0
-
Topoisomerase II
Leishmania donovani MHOM/80/IN/Dd8
Q9XZN0
-
-
Topoisomerase II
-
-
Topoisomerase II
Paramecium bursaria chlorella virus
-
-
Topoisomerase II
-
-
Topoisomerase II
-
-
Topoisomerase II
Pseudomonas aeruginosa PAO
-
-
-
Topoisomerase II
-
-
Topoisomerase II
-
-
topoisomerase II alpha
-
-
topoisomerase II alpha
Danio rerio AB
-
-
-
topoisomerase II alpha
-
isoform
topoisomerase II alpha
P11388
-
topoisomerase IIA
-
-
topoisomerase IIalpha
-
isoform
topoisomerase IIalpha
-
isozyme
topoisomerase IIalpha
P11388
-
topoisomerase IIalpha
-
-
topoisomerase IIalpha
-
-
topoisomerase IIbeta
-
-
topoisomerase IIbeta
Danio rerio TL/WIK
-
-
-
topoisomerase IIbeta
-
-
topoisomerase IIbeta
-
isoform
topoisomerase IIbeta
-
isozyme
topoisomerase IIbeta
-
-
topoisomerase IIbeta
-
-
topoisomerase IV
-
-
Topoisomerase type II
-
-
-
-
topoisomerase-II
-
-
topoisomerase-II
Trypanosoma brucei Lister 427
-
-
-
toposiomerase II
-
-
type I topoisomerase
O29238
-
type II DNA topoisomerase
-
-
type II DNA topoisomerase
-
-
type II DNA topoisomerase
-
-
type II topoisomerase
-
-
type II topoisomerase
Escherichia coli K-12 RFM443
-
-
-
type II topoisomerase
-
-
type II topoisomerase
-
-
type II topoisomerase
-
-
Type II-DNA-topoisomerase
-
-
-
-
type IIA topoisomerase
P66937, Q99XG5
-
Isomerase, deoxyribonucleate topo-, II
-
-
-
-
additional information
-
topoisomerase II is an ATPase belonging to the GHKL family
CAS REGISTRY NUMBER
COMMENTARY
142805-56-9
-
80449-01-0
formerly not distinguished from EC 5.99.1.2
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ecotype Columbia, nuclear encoded enzyme
-
-
Manually annotated by BRENDA team
isoform IIA
-
-
Manually annotated by BRENDA team
fragments
UniProt
Manually annotated by BRENDA team
cauliflower
-
-
Manually annotated by BRENDA team
Chlorella virus Marburg
i.e. CVM-1
-
-
Manually annotated by BRENDA team
Citrobacter spp.
-
-
-
Manually annotated by BRENDA team
Clostridium difficile
-
-
-
Manually annotated by BRENDA team
strain AB, gene can4
-
-
Manually annotated by BRENDA team
Danio rerio AB
strain AB, gene can4
-
-
Manually annotated by BRENDA team
Danio rerio TL/WIK
-
-
-
Manually annotated by BRENDA team
Drosophila sp.
-
-
Manually annotated by BRENDA team
strain RFM443, gene gyrA encoding the A subunit
-
-
Manually annotated by BRENDA team
Escherichia coli K-12 RFM443
strain RFM443, gene gyrA encoding the A subunit
-
-
Manually annotated by BRENDA team
2 isoenzymes: IIalpha and IIbeta
-
-
Manually annotated by BRENDA team
DNA topoisomerase IIbeta
-
-
Manually annotated by BRENDA team
gene TOP2A
-
-
Manually annotated by BRENDA team
isoform IIA
-
-
Manually annotated by BRENDA team
isoform IIalpha
-
-
Manually annotated by BRENDA team
isoform IIalpha
SwissProt
Manually annotated by BRENDA team
isoform IIalpha, commercial product
-
-
Manually annotated by BRENDA team
isoform IIalpha, enzyme is activated in response to genotoxic stress, and enzyme expression is increased following DNA damage
-
-
Manually annotated by BRENDA team
isoform IIbeta
Uniprot
Manually annotated by BRENDA team
isoform topoisomerase IIalpha
-
-
Manually annotated by BRENDA team
isoforms II alpha and II beta
-
-
Manually annotated by BRENDA team
isoforms IIalpha and IIbeta
-
-
Manually annotated by BRENDA team
isoforms TopoIIalpha and TopoIIbeta
-
-
Manually annotated by BRENDA team
isozyme alpha
-
-
Manually annotated by BRENDA team
isozyme IIalpha
-
-
Manually annotated by BRENDA team
isozyme IIbeta
-
-
Manually annotated by BRENDA team
isozymes alpha and beta
-
-
Manually annotated by BRENDA team
isozymes IIalpha and IIbeta
-
-
Manually annotated by BRENDA team
isozymes topo IIalpha and beta
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
recombinant topoisomerase II
-
-
Manually annotated by BRENDA team
topoisomerase II, commercial product
-
-
Manually annotated by BRENDA team
topoisomerase IIalpha
-
-
Manually annotated by BRENDA team
topoisomerase IIalpha
SwissProt
Manually annotated by BRENDA team
two isozymes IIalpha and IIbeta
-
-
Manually annotated by BRENDA team
strain MHOM/80/IN/Dd8
SwissProt
Manually annotated by BRENDA team
Leishmania donovani MHOM/80/IN/Dd8
strain MHOM/80/IN/Dd8
SwissProt
Manually annotated by BRENDA team
two structurally related isoforms
-
-
Manually annotated by BRENDA team
isoform IIalpha
-
-
Manually annotated by BRENDA team
isoform topoisomerase IIbeta
-
-
Manually annotated by BRENDA team
isozyme IIbeta
-
-
Manually annotated by BRENDA team
mouse skin carcinogenesis model, isoforms 2alpha, 2beta
-
-
Manually annotated by BRENDA team
two isoforms of topoisomerase II, termed alpha and beta
-
-
Manually annotated by BRENDA team
encoded by 2 orfs TopoM and TopoN
-
-
Manually annotated by BRENDA team
Paramecium bursaria chlorella virus
i.e. PBCV-1
-
-
Manually annotated by BRENDA team
Paramecium bursaria Chlorella virus-1
-
-
-
Manually annotated by BRENDA team
chloroquine-sensitive and chloroquine-resistant strains
-
-
Manually annotated by BRENDA team
strain PAO1 and a nalidixic acid-resistant mutant strain 10, genes nalA and nalB
-
-
Manually annotated by BRENDA team
strains AC1679-1682
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa AC1679-1682
strains AC1679-1682
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa PAO
strain PAO
-
-
Manually annotated by BRENDA team
isozyme topo IIbeta
-
-
Manually annotated by BRENDA team
topoiomerase IIalpha
-
-
Manually annotated by BRENDA team
haploid strain BY4741
-
-
Manually annotated by BRENDA team
isoform topoisomerase II
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
strains CiproS and CiproR, and a methicillin-resistant strain
-
-
Manually annotated by BRENDA team
subunit A
UniProt
Manually annotated by BRENDA team
subunit B
UniProt
Manually annotated by BRENDA team
Staphylococcus aureus CiproS
strains CiproS and CiproR, and a methicillin-resistant strain
-
-
Manually annotated by BRENDA team
wild-type and a methicillin-resistant strain
-
-
Manually annotated by BRENDA team
wild-type strain and strain Pen I/R
-
-
Manually annotated by BRENDA team
type II DNA topoisomerase VI subunit A and B
O05208 and O05207
SwissProt
Manually annotated by BRENDA team
strain B12
-
-
Manually annotated by BRENDA team
Sulfolobus sp. B12
strain B12
-
-
Manually annotated by BRENDA team
cell line 29-13
-
-
Manually annotated by BRENDA team
clone 221a
-
-
Manually annotated by BRENDA team
Trypanosoma brucei Lister 427
clone 221a
-
-
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
-
Chlorella virus Marburg
-
assay at
50
80
-
50C: no activity, 70-80C: maximal activity
75
85
-
no DNA relaxing activity below 75C and above 80C
PDB
SCOP
CATH
ORGANISM
Acinetobacter baumannii (strain AYE)
Acinetobacter baumannii (strain AYE)
Aquifex aeolicus (strain VF5)
Bacillus subtilis (strain 168)
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Enterococcus faecalis (strain ATCC 700802 / V583)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Francisella tularensis subsp. holarctica (strain LVS)
Francisella tularensis subsp. holarctica (strain LVS)
Francisella tularensis subsp. holarctica (strain LVS)
Francisella tularensis subsp. holarctica (strain LVS)
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Staphylococcus aureus (strain N315)
Staphylococcus aureus (strain N315)
Staphylococcus aureus (strain N315)
Staphylococcus aureus (strain N315)
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pneumoniae serotype A19 (strain TCH8431)
Vibrio fischeri (strain ATCC 700601 / ES114)
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)