Information on EC 5.4.2.8 - phosphomannomutase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
5.4.2.8
-
RECOMMENDED NAME
GeneOntology No.
phosphomannomutase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
show the reaction diagram
-
-
-
-
alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
show the reaction diagram
the cosubstrate glucose-1,6-diphosphate is converted to the corresponding sugar monophosphate while the substrate is converted to the sugar biphosphate in each reaction cycle
-
alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
show the reaction diagram
enzyme is activated by transfer of a phosphate group from mannose-1,6-diphosphate
-
PATHWAY
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
-
Biosynthesis of secondary metabolites
-
Fructose and mannose metabolism
-
GDP-mannose biosynthesis
-
L-ascorbate biosynthesis I (L-galactose pathway)
-
Metabolic pathways
-
SYSTEMATIC NAME
IUBMB Comments
alpha-D-mannose 1,6-phosphomutase
alpha-D-Mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
alpha-phosphomannomutase1
Q92871
-
EC 2.7.5.7
-
-
formerly
-
IMP-sensitive glucose-1,6-bisphosphatase
-
-
ORF17
-
-
-
-
PGM/PMM
Sphingobium chungbukense DJ77
-
-
-
PGM2
-
Giardia has two proteins with phosphoglucomutase activity, one of which (PGM2) also has phosphomannomutase activity
phosphomannomutase
O80840
-
phosphomannomutase
-
-
phosphomannomutase
-
-
phosphomannomutase
Q9KZL6
-
phosphomannomutase
B6Z254
-
phosphomannomutase 1
-
-
phosphomannomutase 2
O15305
-
phosphomannomutase/phosphoglucomutase
-
-
Phosphomannose mutase
-
-
-
-
Phosphomutase, mannose
-
-
-
-
PMM
-
-
-
-
PMM
C8C16, C8CK15, C8CK16
-
PMM
C8CK06, C8CK09, C8CK10
-
PMM
-, C8CK11, C8CK12, C8CK13
-
PMM
-
-
PMM-1
-
isoform
PMM-2
O15305
-
PMM-A1
C8CK06
isoform
PMM-A1
C8CK11
isoform
PMM-A1
-
isoform
PMM-B1
C8CK12
isoform
PMM-B2
C8CK13
isoform
PMM-D1
C8CK15
isoform
PMM-D1
C8CK09
isoform
PMM-D2
C8C16, C8CK16
isoform
PMM-D2
C8CK10
isoform
PMM/PGM
-
bifunctinal enzyme
PMM/PGM
-
bifunctional enzyme
PMM/PGM
-
bifunctional enzyme
PMM/PGM
Pyrococcus horikoshii OT-3
-
bifunctional enzyme
-
PMM1
-
multifunctional enzyme
PMMH-22
-
-
-
-
SP-2
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase activities
SP-2
Sphingobium chungbukense DJ77
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase activities
-
CAS REGISTRY NUMBER
COMMENTARY
59536-73-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
isoform PMM-D1; cultivars AS67 and AS91
UniProt
Manually annotated by BRENDA team
isoform PMM-D2; cultivars AS67 and AS91
C8C16, C8CK16
UniProt
Manually annotated by BRENDA team
syncytia induced by nematode Heterodera schachtii
UniProt
Manually annotated by BRENDA team
cultivar Bd21
-
-
Manually annotated by BRENDA team
Cassia corymbosa
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
human liver enzyme and recombinant PMM1 from individuals with carbohydrate-deficient glycoprotein syndrome type I
-
-
Manually annotated by BRENDA team
isoform alpha-PMM1
SwissProt
Manually annotated by BRENDA team
isoform alpha-PMM2
SwissProt
Manually annotated by BRENDA team
cultivar Betzes
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
bifunctional phosphomannomutase/phosphoglucomutase
-
-
Manually annotated by BRENDA team
wild-type strains and alginate-producing strains
-
-
Manually annotated by BRENDA team
Pyrococcus horikoshii OT-3
OT3
-
-
Manually annotated by BRENDA team
sec53 cells are deficient in phosphomannomutase
-
-
Manually annotated by BRENDA team
Sphingobium chungbukense DJ77
strain DJ77
-
-
Manually annotated by BRENDA team
isoform PMM-A1; cultivars Xiaoyan 54 and Chinese Spring
UniProt
Manually annotated by BRENDA team
isoform PMM-D1; cultivars Xiaoyan 54 and Chinese Spring
UniProt
Manually annotated by BRENDA team
isoform PMM-D2; cultivars Xiaoyan 54 and Chinese Spring
UniProt
Manually annotated by BRENDA team
cultivar Langdon
-
-
Manually annotated by BRENDA team
isoform PMM-A1; cultivar Langdon
UniProt
Manually annotated by BRENDA team
isoform PMM-B1; cultivar Langdon
UniProt
Manually annotated by BRENDA team
isoform PMM-B2; cultivar Langdon
UniProt
Manually annotated by BRENDA team
cultivars DV877 and IE29-1
-
-
Manually annotated by BRENDA team
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.12
-
C0JP35, -
calculated from amino acid sequence
PDB
SCOP
CATH
ORGANISM
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.5
-
-
maximal stability
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Mg2+ stabilizes
-
higly unstable during storage
-
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, stable for at least 2 months
-
0-4°C, 50% glycerol, 12 h, 70% loss of activity
-
0-4°C, 50% glycerol, 3-4 d, complete loss of activity
-