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Information on EC 5.4.2.2 - phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) and Organism(s) Dictyostelium discoideum

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EC Tree
IUBMB Comments
Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. The enzyme also catalyses (more slowly) the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5, phosphoglucomutase (glucose-cofactor).
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Dictyostelium discoideum
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphoglucomutase, phosphoglucomutase 1, phosphomannomutase/phosphoglucomutase, pmm/pgm, alpha-phosphoglucomutase, pgm/pmm, alpha-pgm, phosphoglucose mutase, phosphoglucomutase1, plastidic phosphoglucomutase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Glucose phosphomutase
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-
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PGM
-
-
-
-
PGM1
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-
-
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PGM2
-
-
-
-
Phosphoglucose mutase
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-
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Phosphomutase, glucose
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
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SYSTEMATIC NAME
IUBMB Comments
alpha-D-glucose 1,6-phosphomutase
Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. The enzyme also catalyses (more slowly) the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5, phosphoglucomutase (glucose-cofactor).
CAS REGISTRY NUMBER
COMMENTARY hide
9001-81-4
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PGM1_DICDI
572
0
63230
Swiss-Prot
other Location (Reliability: 2)
PGM2_DICDI
603
0
67535
Swiss-Prot
other Location (Reliability: 1)