Information on EC 5.3.4.1 - Protein disulfide-isomerase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
5.3.4.1
-
RECOMMENDED NAME
GeneOntology No.
Protein disulfide-isomerase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
intramolecular oxidoreduction
-
-
-
-
isomerization
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Protein disulfide-isomerase
Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5'-MD
-
-
-
-
58 kDa glucose regulated protein
-
-
-
-
58 kDa microsomal protein
-
-
-
-
AGR2
-
-
anterior gradient homolog 2
-
-
BPA-binding protein
-
-
CaBP1
-
-
-
-
CaBP2
-
-
-
-
CaBP2
P13667
-
CaBP2
P38659
-
Cellular thyroid hormone binding protein
-
-
-
-
cotyledon-specific chloroplast biogenesis factor CYO1
Q93YN0
-
disulfide bond isomerase
-
-
disulfide bond-forming enzyme
-
-
Disulfide interchange enzyme
-
-
-
-
disulfide isomerase
-
-
Disulfide isomerase ER-60
-
-
-
-
disulfide-bond isomerase
-
-
DsbA
-
-
-
-
DsbC
-
-
-
-
DsbD
-
-
-
-
Endoplasmic reticulum protein EUG1
-
-
-
-
ER protein 57
-
-
ER58
-
-
-
-
ERcalcistorin/protein-disulfide isomerase
-
i.e. ECaSt/PDI
ERcalcistorin/protein-disulfide isomerase
-
-
ERcalcistorin/protein-disulfide isomerase
Sea urchin
-
i.e. ECaSt/PDI
ERP-57
-
-
ERp-72 homolog
-
-
-
-
ERp18
-
-
ERp27
Q96DN0
-
ERp44
-
-
ERp57
-
-
-
-
ERp57
P30101
-
ERp57
-
-
ERp57
P38659
-
ERP59
-
-
-
-
ERP60
-
-
-
-
ERp72
-
-
-
-
ERp72
P13667
-
ERp72
P38659
-
fibronectin
-
extracellular matrix protein fibronectin contains an intrinsic protein-disulfide isomerase activity
gPDI-1
O97451
-
gPDI-2
O97452
-
gPDI-3
Q9U015
-
HIP-70
-
-
-
-
multifunctional protein disulfide isomerase
P07237, P13667, P30101, Q13087
-
P5
-
PDI homologue
P55
-
-
-
-
P58
-
-
-
-
pancreas-specific protein disulfide isomerase
-
-
pancreas-specific protein disulfide isomerase
Q13087
-
pancreas-specific protein disulfide isomerase
-
-
PDI
-
-
-
-
PDI
Q1HGL1
-
PDI
A5LHV9, A5LHW0, A5LHW1
-
PDI
P13667
-
PDI
A7YBW7, A7YBX0, A7YBX2, A7YBX4
-
PDI
Q53LQ0, Q67UF5
-
PDI
Q4Z2V7
-
PDI
Q4Z2V7
-
-
PDI
AY919669
-
PDI
Plasmodium knowlesi H
Q2XQR5
-
-
PDI
Q2XQR3
-
PDI
Plasmodium vivax Sal1
Q2XQR3
-
-
PDI
Q7RRT0
-
PDI
Saccharomyces cerevisiae trg1/TRG1
-
-
-
PDI
Schizosaccharomyces pombe KP1
O13811
-
-
PDI
Streptomyces sp. NCIM 5127
-
-
-
PDI A4
P13667
-
PDI I
-
-
PDI II
-
-
pdi-15
A7YBX4
-
pdi-40
A7YBX2
-
pdi-47
A7YBX0
-
pdi-52
A7YBW7
-
PDI-P5
E1CAJ6
-
PDI-related protein
-
-
PDIA1
P07237
-
PDIA2
Q13087
-
PDIA3
-
-
PDIA3
D0QEL0
-
PDIA3
E1CAJ6
-
PDIA4
P13667
-
PDIL-1
-
-
PDIL-2
-
-
PDIL1-1
Q53LQ0
-
PDIL2-3
Q67UF5
-
PDILT
-
-
PDIp
-
-
-
-
PDIp
Q13087
-
PDIp
-
-
PDIp
-
-
PDIr
-
-
protein disulfide isomaerase
-
-
protein disulfide isomaerase
Saccharomyces cerevisiae trg1/TRG1
-
-
-
protein disulfide isomerase
A0SHR2
-
protein disulfide isomerase
-
-
protein disulfide isomerase
Q93YN0
-
protein disulfide isomerase
-
-
protein disulfide isomerase
-, A3RMS2
-
protein disulfide isomerase
-
-
protein disulfide isomerase
Chlamydomonas reinhardtii 2137a
-
-
-
protein disulfide isomerase
Q1HGL1
-
protein disulfide isomerase
-
-
protein disulfide isomerase
-
-
protein disulfide isomerase
-
-
protein disulfide isomerase
-
-
protein disulfide isomerase
-
-
protein disulfide isomerase
P13667
-
protein disulfide isomerase
-
-
protein disulfide isomerase
Q9C1Z8
-
protein disulfide isomerase
-
-
protein disulfide isomerase
-
-
protein disulfide isomerase
P27773
-
protein disulfide isomerase
-
-
protein disulfide isomerase
Q53LQ0, Q67UF5
-
protein disulfide isomerase
Q4Z2V7
-
protein disulfide isomerase
Q4Z2V7
-
-
protein disulfide isomerase
Q5UAH0
-
protein disulfide isomerase
-
-
protein disulfide isomerase
AY919669
-
protein disulfide isomerase
Q2XQR5
-
protein disulfide isomerase
Plasmodium knowlesi H
Q2XQR5
-
-
protein disulfide isomerase
Q2XQR3
-
protein disulfide isomerase
Plasmodium vivax Sal1
Q2XQR3
-
-
protein disulfide isomerase
Q7RRT0
-
protein disulfide isomerase
P38659
-
protein disulfide isomerase
-
-
protein disulfide isomerase
D0EJL8
-
protein disulfide isomerase
O13811
-
protein disulfide isomerase
Schizosaccharomyces pombe KP1
O13811
-
-
protein disulfide isomerase
-
-
protein disulfide isomerase
Streptomyces sp. NCIM 5127
-
-
-
protein disulfide isomerase
P12865
-
protein disulfide isomerase 3
Q9U015
-
protein disulfide isomerase A1
-
-
protein disulfide isomerase A3
P27773
-
protein disulfide isomerase A3
-
-
protein disulfide isomerase associated 3
D0QEL0
-
Protein disulfide isomerase P5
-
-
-
-
protein disulfide isomerase-1
A5LHW0
-
protein disulfide isomerase-2
A5LHV9
-
protein disulfide isomerase-3
A5LHW1
-
protein disulfide isomerase-like protein of the testis
-
-
protein disulfide isomerase-P5
E1CAJ6
-
protein disulfide isomerase-related chaperone Wind
-
-
Protein disulfide isomerase-related protein
-
-
-
-
protein disulfide isomerase::
-
-
protein disulfide oxidoreductase
-
-
protein disulfide-isomerase A4
P38659
-
Protein disulphide isomerase
-
-
-
-
Protein disulphide isomerase
-
-
Protein disulphide isomerase
-
-
Protein ERp-72
-
-
-
-
protein-disulfide isomerase
-
-
protein-disulfide isomerase
-
-
protein-disulfide isomerase
A7YBW7, A7YBX0, A7YBX2, A7YBX4
-
protein-disulfide isomerase
-
-
protein-disulfide isomerase
-
-
R-cognin
-
-
-
-
RB60
Chlamydomonas reinhardtii 2137a
-
-
-
Rearrangease
-
-
-
-
Reduced ribonuclease reactivating enzyme
-
-
-
-
Retina cognin
-
-
-
-
S-S rearrangase
-
-
-
-
thiol-protein oxidoreductase
Q1HGL1
-
Thyroid hormone-binding protein
-
-
-
-
Thyroxine deiodinase
-
-
-
-
Iodothyronine 5'-monodeiodinase
-
-
-
-
additional information
A0SHR2
the enzyme belongs to the family of protein disulfide isomerases
additional information
-
PDI belongs to the thioredoxin superfamily
additional information
-
PDI, DsbC, and DbsG belong to the thioredoxin superfamily
additional information
-
the enzyme belongs to the Dsb family
additional information
-
the enzyme is a member of the thioredoxin fold superfamily
additional information
-
protein disulfide-isomerase is identical with the beta-subunit of the prolyl 4-hydroxylase tetramer
additional information
-
PDI and other PDI family proteins are members of the thioredoxin superfamily
additional information
-
ERP-57 is a member of the thiol oxidoreductase family
additional information
-
PDI belongs to the thioredoxin superfamily
additional information
-
protein disulfide isomerase is identical to the beta-subunit of prolyl-4-hydroxylase
additional information
-
protein disulfide isomerase is identical to the beta-subunit of prolyl-4-hydroxylase; thyroid hormone binding protein is apparently identical to protein disulfide isomerase
additional information
-
the enzyme belongs to the protein disulfide isomerase family
additional information
-
the enzyme belongs to the yeast hPDI enzyme family
additional information
-
the enzyme is a member of the PDI family
additional information
-
the enzyme is a member of the protein disulfide isomerase family of oxidoreductases
additional information
P07237, P13667, P30101
the enzyme belongs to the protein disulfide isomerase family
additional information
Q13087
PDIp is a member of the protein disulfide isomerase PDI family
additional information
Q13087
the enzyme belongs to the protein disulfide isomerase family
additional information
Q96DN0
the enzyme belongs to the family of protein disulfide isomerases
additional information
-
protein disulfide isomerase is identical to the beta-subunit of prolyl-4-hydroxylase
additional information
-
the enzyme is a member of the PDI enzyme family
additional information
-
the enzyme is a member of the PDI family
additional information
-
PDI belongs to the thioredoxin superfamily
additional information
-
PDI, Eug1p, Mpd1p, Mpd2p, and Eps1p belong to the thioredoxin superfamily
additional information
-
the enzymes yPDI, Mpd1p, Mpd2p, and Eug1p belong to the yeast yPDI enzyme family
additional information
Saccharomyces cerevisiae trg1/TRG1
-
the enzymes yPDI, Mpd1p, Mpd2p, and Eug1p belong to the yeast yPDI enzyme family
-
CAS REGISTRY NUMBER
COMMENTARY
37318-49-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
a tick cultured on rabbit hosts, constitutive gene
SwissProt
Manually annotated by BRENDA team
12 genes coding for protein disulfide isomerase. Expression of six PDI genes is significantly up-regulated by unfolded protein response and sharply attenuated by the transcription inhibitor, actinomycin D. PDI and binding protein BIP2 expression is not affected in the unfolded protein response signaling mediator Atire1-2 mutant. The expression of four PDI genes is decreased in the unfolded protein response signaling mediator Atbzip60 mutant
-
-
Manually annotated by BRENDA team
calf
-
-
Manually annotated by BRENDA team
ox; protein disulfide isomerase activity and glutathione-insulin transhydrogenase activity, EC 1.8.4.2, are catalyzed by a single enzyme protein
-
-
Manually annotated by BRENDA team
protein disulfide isomerase activity and glutathione-insulin transhydrogenase activity, EC 1.8.4.2, are catalyzed by a single enzyme protein
-
-
Manually annotated by BRENDA team
thyroid hormone binding protein is apparently identical to protein disulfide isomerase
-
-
Manually annotated by BRENDA team
isozyme PDI-2; wild-type strain N2 and diverse mutant strains, overview, isozymes PDI-1, PDI-2 and PDI-3 encoded by genes pdi-1, pdi-2 and pdi-3
SwissProt
Manually annotated by BRENDA team
wild-type strain N2 and diverse mutant strains, overview, isozymes PDI-1 and PDI-3 encoded by genes pdi-1 and pdi-3
-
-
Manually annotated by BRENDA team
Chlamydomonas reinhardtii 2137a
strain 2137a
-
-
Manually annotated by BRENDA team
a marine snail
-
-
Manually annotated by BRENDA team
isoform Pdi-2
-
-
Manually annotated by BRENDA team
gene dsbB
-
-
Manually annotated by BRENDA team
isozymes DsbC and DsbG
-
-
Manually annotated by BRENDA team
proteins with protein disulfide isomerase activity: DsbA, DsbC and DsbD
-
-
Manually annotated by BRENDA team
several strains, overview
-
-
Manually annotated by BRENDA team
protein disulfide-isomerase is identical with the beta-subunit of the prolyl 4-hydroxylase tetramer, alpha2beta2
-
-
Manually annotated by BRENDA team
; PD-2 precursor
SwissProt
Manually annotated by BRENDA team
; PD-3 precursor
SwissProt
Manually annotated by BRENDA team
cv. Jack, genes PDIS-1 and PDIS-2
-
-
Manually annotated by BRENDA team
cv. Jack, isozymes GmPDIL-1, GmPDIL-2, GmPDIL-3a, and GmPDIL-3b
-
-
Manually annotated by BRENDA team
isoform Pdi-1
SwissProt
Manually annotated by BRENDA team
isoform Pdi-2
A5LHV9
SwissProt
Manually annotated by BRENDA team
isoform Pdi-3
SwissProt
Manually annotated by BRENDA team
isozyme HlPDI-1; a tick cultured on rabbit hosts, gene HlPDI-1
SwissProt
Manually annotated by BRENDA team
isozyme HlPDI-2; a tick cultured on rabbit hosts, gene HlPDI-2
A5LHV9
SwissProt
Manually annotated by BRENDA team
isozyme HlPDI-3; a tick cultured on rabbit hosts, gene HlPDI-3
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
ERp27
SwissProt
Manually annotated by BRENDA team
ERp57
SwissProt
Manually annotated by BRENDA team
ERp72 or PDIA4, respecitvely
SwissProt
Manually annotated by BRENDA team
isoform ERdj5; isoform PDI
-
-
Manually annotated by BRENDA team
isoform pancreas-specific protein disulfide isomerase homolog, PDIp
-
-
Manually annotated by BRENDA team
isoform PDI
-
-
Manually annotated by BRENDA team
isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit
-
-
Manually annotated by BRENDA team
PDIA1
SwissProt
Manually annotated by BRENDA team
PDIA2 precursor
SwissProt
Manually annotated by BRENDA team
protein disulfide isomerase is identical to the beta-subunit of prolyl-4-hydroxylase
-
-
Manually annotated by BRENDA team
protein disulfide isomerase is identical to the beta-subunit of prolyl-4-hydroxylase; thyroid hormone binding protein is apparently identical to protein disulfide isomerase
-
-
Manually annotated by BRENDA team
recombinant enzyme obtained from Escherichia coli strain BL21
-
-
Manually annotated by BRENDA team
15 kDa isozyme, fragment
SwissProt
Manually annotated by BRENDA team
40 kDa isozyme, fragment
SwissProt
Manually annotated by BRENDA team
47 kDa isozyme, fragment
SwissProt
Manually annotated by BRENDA team
52 kDa isozyme
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
protein disulfide isomerase is identical to the beta-subunit of prolyl-4-hydroxylase
-
-
Manually annotated by BRENDA team
male Balb/c or CD1 mice
-
-
Manually annotated by BRENDA team
male C57BL/6 mice
-
-
Manually annotated by BRENDA team
PDIA3; C57BL/6 mice
UniProt
Manually annotated by BRENDA team
cultivar Kinmaze
UniProt
Manually annotated by BRENDA team
strain ANKA, isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
strain ANKA, isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
chabaudi
UniProt
Manually annotated by BRENDA team
chimeric PDI mutant containing Pichia pastoris signal sequence and ER retention sequence
AY919669
GenBank
Manually annotated by BRENDA team
strain 3D7
-
-
Manually annotated by BRENDA team
strain 3D7, isozymes PDI-8, PDI-9, PDI-11, and PDI-14
-
-
Manually annotated by BRENDA team
strains 3D7 and FcB1, isozyme PDI-22
-
-
Manually annotated by BRENDA team
strain H, isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
Plasmodium knowlesi H
strain H, isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
strain Sal1, isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
Plasmodium vivax Sal1
strain Sal1, isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
isozyme PDI-8
SwissProt
Manually annotated by BRENDA team
genes dsbA and dsbC
-
-
Manually annotated by BRENDA team
adult and newborn
-
-
Manually annotated by BRENDA team
Fischer 344 rats
-
-
Manually annotated by BRENDA team
glutathione-insulin transhydrogenase and protein disulfide-isomerase are both not catalyzed by a single enzyme species
-
-
Manually annotated by BRENDA team
Sprague Dawley rats
-
-
Manually annotated by BRENDA team
several strans, overview
-
-
Manually annotated by BRENDA team
strain trg1/TRG1
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae trg1/TRG1
strain trg1/TRG1
-
-
Manually annotated by BRENDA team
-
D0QEL0
UniProt
Manually annotated by BRENDA team
precursor; strain KP1
UniProt
Manually annotated by BRENDA team
Schizosaccharomyces pombe KP1
precursor; strain KP1
UniProt
Manually annotated by BRENDA team
Sea urchin
-
-
-
Manually annotated by BRENDA team
NCIM 5127
-
-
Manually annotated by BRENDA team
Streptomyces sp. NCIM 5127
NCIM 5127
-
-
Manually annotated by BRENDA team
PDI-P5; isozymes PDIA3 and PDI-P5
UniProt
Manually annotated by BRENDA team
PDI-2; two PDI enzyme forms, which contain one or two double-cysteine redox-active sites and correspond to a single domain PDI and a class 1 PDI, i.e. PDI-1 and PDI-2
SwissProt
Manually annotated by BRENDA team
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.447
-
acrolein
-
pH 6.3, 38C
0.311
-
iodoacetamide
-
pH 6.3, 38C
0.124
-
N-ethylmaleimide
-
pH 6.3, 38C
0.179
-
iodoacetate
-
pH 6.3, 38C
additional information
-
additional information
-
pseudo-first-order and second-order kinetics
-
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.6
-
-
PDI C-terminal extension domain, isoelectric focusing
6.64
-
A0SHR2, -
isoelectric focusing
PDB
SCOP
CATH
ORGANISM
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Neisseria meningitidis serogroup B (strain MC58)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Salmonella typhimurium
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5
-
-
unstable
5
-
-
stable
10
-
-
1 h, 0C or 37C, highest stability