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Information on EC 5.3.3.1 - steroid DELTA-isomerase and Organism(s) Bos taurus

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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.1 steroid DELTA-isomerase
IUBMB Comments
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
3beta-hsd, ketosteroid isomerase, delta 5-3-ketosteroid isomerase, steroid isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, steroid delta-isomerase, gst a3-3, 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase, 3beta-hsd/isomerase, 5-ene-4-ene isomerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-Keto-DELTA5-steroid isomerase
-
-
-
-
3-Ketosteroid DELTA5-->DELTA4-isomerase
-
-
-
-
3-Oxo steroid DELTA4-DELTA5-isomerase
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-
-
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3-Oxo-delta5 steroid isomerase
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-
-
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3-Oxosteroid DELTA4-DELTA5-isomerase
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-
-
-
3-Oxosteroid DELTA5-DELTA4-isomerase
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-
-
-
3-Oxosteroid isomerase
-
-
-
-
3beta-HSD/isomerase
-
-
5-Ene-4-ene isomerase
-
-
-
-
5-Pregnene-3,20-dione isomerase
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-
-
-
delta 5-3-ketosteroid isomerase
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-
-
-
DELTA-3-ketosteroid isomerase
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-
-
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Delta-5-3-ketosteroid isomerase
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-
-
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DELTA5(or DELTA4)-3-keto steroid isomerase
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-
-
-
DELTA5-3-keto steroid isomerase
-
-
-
-
DELTA5-3-ketosteroid isomerase
-
-
-
-
DELTA5-3-oxosteroid isomerase
-
-
-
-
DELTA5-ketosteroid isomerase
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-
-
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DELTA5-steroid isomerase
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-
-
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Hydroxysteroid isomerase
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-
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Isomerase, steroid DELTA
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-
-
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Steroid 5-->4-isomerase
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-
-
-
Steroid isomerase
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
-
-
-
-
isomerization
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3-oxosteroid DELTA5-DELTA4-isomerase
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
CAS REGISTRY NUMBER
COMMENTARY hide
9031-36-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DELTA5-pregnen-3,20-dione
?
show the reaction diagram
-
-
-
?
pregn-5-ene-3,20-dione-17alpha-ol
17alpha-hydroxyprogesterone
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17beta-estradiol
-
IC50: 0.0003 mM
3-Oxo-4-aza steroids
-
-
Biochanin A
-
IC50: 0.0004 mM
daidzein
-
IC50: 0.0038 mM
formononetin
-
IC50: 0.004 mM
genistein
-
IC50: 0.0023 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
DELTA5-pregnen-3,20-dione
-
25°C, pH 7.5
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.303
DELTA5-pregnen-3,20-dione
-
25°C, pH 7.5
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0003
17beta-estradiol
Bos taurus
-
IC50: 0.0003 mM
0.0004
Biochanin A
Bos taurus
-
IC50: 0.0004 mM
0.0038
daidzein
Bos taurus
-
IC50: 0.0038 mM
0.004
formononetin
Bos taurus
-
IC50: 0.004 mM
0.0023
genistein
Bos taurus
-
IC50: 0.0023 mM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.5
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
3BHS_BOVIN
373
0
42220
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
-
2 * 45000, 3beta-hydroxy-5-ene steroid dehydrogenase/isomerase enzyme system, SDS-PAGE
81000
-
3beta-hydroxy-5-ene steroid dehydrogenase/steroid DELTA-isomerase system, gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 45000, 3beta-hydroxy-5-ene steroid dehydrogenase/isomerase enzyme system, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
3beta-hydroxy-5-ene steroid dehydrogenase/isomerase enzyme system
-
3beta-hydroxy-5-ene-steroid dehydrogenase/steroid DELTA5-DELTA4-ene isomerase enzyme complex
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cherradi, N.; Guidicelli, C.; Defaye, G.; Chambaz, E.M.
Purification and characterization of 3beta-hydroxysteroid-dehydrogenase/isomerase from bovine adrenal cortex
J. Steroid Biochem. Mol. Biol.
41
831-836
1992
Bos taurus
Manually annotated by BRENDA team
Brandt, M.; Levy, M.A.
3beta-Hydroxy-DELTA5-steroid dehydrogenase/3-keto-DELTA5-steroid isomerase from bovine adrenals: mechanism of inhibition by 3-oxo-4-aza steroids and kinetic mechanism of the dehydrogenase
Biochemistry
28
140-148
1989
Bos taurus
Manually annotated by BRENDA team
Wong, C.K.; Keung, W.M.
Bovine adrenal 3beta-hydroxysteroid dehydrogenase (E.C. 1.1.1.145)/5-ene-4-ene isomerase (E.C. 5.3.3.1): characterization and its inhibition by isoflavones
J. Steroid Biochem. Mol. Biol.
71
191-202
1999
Bos taurus
Manually annotated by BRENDA team
Ewald, W.; Werbin, H.; Chaikoff, I.L.
Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex
Biochim. Biophys. Acta
111
306-12
1965
Bos taurus
Manually annotated by BRENDA team