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Information on EC 5.3.1.9 - glucose-6-phosphate isomerase and Organism(s) Bos taurus

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IUBMB Comments
The enzyme from yeast catalyses the reversible conversion specifically between the alpha-D-glucose 6-phosphate and beta-D-fructofuranose 6-phosphate. The enzyme also catalyses the anomerization of both D-hexose 6-phosphates .
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphoglucose isomerase, glucose-6-phosphate isomerase, glucose phosphate isomerase, autocrine motility factor, phosphoglucoisomerase, phosphohexose isomerase, neuroleukin, pgi/amf, amf/pgi, glucose 6-phosphate isomerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-Phosphoglucose isomerase
-
-
-
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D-Glucose-6-phosphate isomerase
-
-
-
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D-glucose-6-phosphate ketol-isomerase
-
-
-
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Glucose 6-phosphate isomerase
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-
-
-
Glucose phosphate isomerase
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-
-
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Glucose phosphoisomerase
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-
-
-
Glucosephosphate isomerase 2
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-
-
-
GPI
-
-
-
-
Hexose 6-phosphate isomerase
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-
-
-
Hexose isomerase
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-
-
-
Hexose monophosphate isomerase
-
-
-
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Hexose phosphate isomerase
-
-
-
-
Hexosephosphate isomerase
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-
-
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Isomerase, glucose phosphate
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-
-
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Neuroleukin
-
-
-
-
NLK
-
-
-
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Oxoisomerase
-
-
-
-
PGI
-
-
-
-
PGI2
-
-
-
-
PGI3
-
-
-
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PHI
-
-
-
-
Phosphoglucoisomerase
-
-
-
-
Phosphoglucose isomerase
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-
-
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Phosphohexoisomerase
-
-
-
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Phosphohexomutase
-
-
-
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Phosphohexose isomerase
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-
-
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Phosphosaccharomutase
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-
-
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SA-36
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-
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Sperm antigen-36
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-
-
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VEG54
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-
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Vegetative protein 54
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
-
-
-
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isomerization
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
The enzyme from yeast catalyses the reversible conversion specifically between the alpha-D-glucose 6-phosphate and beta-D-fructofuranose 6-phosphate. The enzyme also catalyses the anomerization of both D-hexose 6-phosphates [7].
CAS REGISTRY NUMBER
COMMENTARY hide
9001-41-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Fructose 6-phosphate
Glucose 6-phosphate
show the reaction diagram
-
r
-
?
Glucose 6-phosphate
Fructose 6-phosphate
show the reaction diagram
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r
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.07 - 0.46
fructose 6-phosphate
0.12 - 0.58
glucose 6-phosphate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
G6PI_BOVIN
557
0
62855
Swiss-Prot
other Location (Reliability: 2)
A0A3Q1MP70_BOVIN
565
0
63636
TrEMBL
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
118000
-
isoenzymes 1-4, gel filtration
48000
-
mammary gland, low speed sedimentation without reaching equilibrium
59000
-
2 * 59000, isoenzyme 1-5, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
the most basic of the five isoenzymes is more stable than the more acidic isoenzymes at pH extremes, at high ionic strength, in the presence of denaturants, or upon exposure to proteases
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
5 isoenzymes
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Noltmann, E.A.
Aldose-ketose isomerases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
6
271-354
1972
Apis mellifera, Aspergillus niger, Bos taurus, Canis lupus familiaris, Entamoeba sp., Escherichia coli, Homo sapiens, Klebsiella aerogenes, Mycobacterium tuberculosis, Oryctolagus cuniculus, Pisum sativum, Rattus norvegicus, Saccharomyces cerevisiae, Schistosoma mansoni, Sus scrofa, Trypanosoma sp.
-
Manually annotated by BRENDA team
Cini, J.K.; Cook, P.F.; Gracy, R.W.
Molecular basis for the isozymes of bovine glucose-6-phosphate isomerase
Arch. Biochem. Biophys.
263
96-106
1988
Bos taurus
Manually annotated by BRENDA team