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Information on EC 5.2.1.8 - peptidylprolyl isomerase and Organism(s) Gallus gallus

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EC Tree
IUBMB Comments
The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
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Gallus gallus
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
cyclophilin, cyclophilin a, fkbp12, ppiase, fkbp51, trigger factor, fkbp52, fk506-binding protein, peptidyl-prolyl isomerase, cyclophilin b, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
12 kDa FKBP
-
-
-
-
12.6 kDa FKBP
-
-
-
-
13 kDa FKBP
-
-
-
-
15 kDa FKBP
-
-
-
-
19 kDa FK506-binding protein
-
-
-
-
22 kDa FK506-binding protein
-
-
-
-
25 kDa FKBP
-
-
-
-
27 kDa membrane protein
-
-
-
-
36 kDa FK506 binding protein
-
-
-
-
40 kDa thylakoid lumen PPIase
-
-
-
-
40 kDa thylakoid lumen rotamase
-
-
-
-
51 kDa FK506-binding protein
-
-
-
-
52 kDa FK506 binding protein
-
-
-
-
54 kDa progesterone receptor-associated immunophilin
-
-
-
-
65 kDa FK506-binding protein
-
-
-
-
CGI-124
-
-
-
-
Chl-Mip
-
-
-
-
CPH
-
-
-
-
Cyclophilin
-
-
-
-
Cyclophilin 18
-
-
-
-
Cyclophilin 33
-
-
-
-
Cyclophilin A
-
-
-
-
Cyclophilin B
-
-
-
-
Cyclophilin C
-
-
-
-
Cyclophilin cyp2
-
-
-
-
Cyclophilin homolog
-
-
-
-
Cyclophilin ScCypA
-
-
-
-
Cyclophilin ScCypB
-
-
-
-
Cyclophilin-10
-
-
-
-
Cyclophilin-11
-
-
-
-
Cyclophilin-40
-
-
-
-
Cyclophilin-60
-
-
-
-
Cyclophilin-like protein Cyp-60
-
-
-
-
Cyclophilin-related protein
-
-
-
-
Cyclosporin A-binding protein
-
-
-
-
CYP-40
-
-
-
-
CYP-S1
-
-
-
-
Cyp3 PPIase
-
-
-
-
CyPA
-
-
-
-
CyPB
-
-
-
-
Estrogen receptor binding cyclophilin
-
-
-
-
FF1 antigen
-
-
-
-
FKBP
-
-
-
-
FKBP-12
-
-
-
-
FKBP-12.6
-
-
-
-
FKBP-13
-
-
-
-
FKBP-15
-
-
-
-
FKBP-19
-
-
-
-
FKBP-21
-
-
-
-
FKBP-22
-
-
-
-
FKBP-23
-
-
-
-
FKBP-25
-
-
-
-
FKBP-36
-
-
-
-
FKBP-51
-
-
-
-
FKBP-70
-
-
-
-
FKBP22
-
-
-
-
FKBP52 protein
-
-
-
-
FKBP54
-
-
-
-
FKBP59
-
-
-
-
FKBP65
-
-
-
-
FKBP65RS
-
-
-
-
HBI
-
-
-
-
Histidine rich protein
-
-
-
-
hPar14
-
-
-
-
HSP binding immunophilin
-
-
-
-
HSP90-binding immunophilin
-
-
-
-
Immunophilin FKBP12
-
-
-
-
Immunophilin FKBP12.6
-
-
-
-
Immunophilin FKBP36
-
-
-
-
Immunophilin FKBP65
-
-
-
-
Isomerase, peptidylprolyl cis-trans
-
-
-
-
Macrolide binding protein
-
-
-
-
Macrophage infectivity potentiator
-
-
-
-
MtFK
-
-
-
-
Nucleolar proline isomerase
-
-
-
-
p17.7
-
-
-
-
P31
-
-
-
-
P54
-
-
-
-
p59 protein
-
-
-
-
Par14
-
-
-
-
Parvulin
-
-
-
-
Parvulin 14
-
-
-
-
Peptide bond isomerase
-
-
-
-
Peptidyl-prolyl cis-trans isomerase
-
-
-
-
Peptidyl-prolyl cis-trans isomerase plp
-
-
-
-
Peptidyl-prolyl cis-trans isomerase surA
-
-
-
-
Peptidyl-prolyl cis/trans isomerase EPVH
-
-
-
-
Peptidylprolyl cis-trans isomerase
-
-
-
-
PfCyP
-
-
-
-
Planta-induced rust protein 28
-
-
-
-
PPIase
-
-
-
-
PPIase Pin1
-
-
-
-
PPIase Pin4
-
-
-
-
Proline rotamase
-
-
-
-
Proteins, cyclophilins
-
-
-
-
Proteins, specific or class, cyclophilins
-
-
-
-
Rapamycin-binding protein
-
-
-
-
Rapamycin-selective 25 kDa immunophilin
-
-
-
-
Rotamase
-
-
-
-
Rotamase Pin1
-
-
-
-
Rotamase Pin4
-
-
-
-
Rotamase plp
-
-
-
-
S-cyclophilin
-
-
-
-
S1205-06
-
-
-
-
SCYLP
-
-
-
-
SmCYP A
-
-
-
-
SmCYP B
-
-
-
-
Smp17.7
-
-
-
-
SP18
-
-
-
-
WHP
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Peptidylproline cis-trans-isomerase
The first type of this enzyme found [1] proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
CAS REGISTRY NUMBER
COMMENTARY hide
95076-93-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
succinyl-Ala-Ala-(cis)-Pro-Phe 4-methylcoumarin 7-amide
succinyl-Ala-Ala-(trans)-Pro-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
succinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-Gln-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-Gln-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-Glu-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-Glu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-Gly-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-Gly-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-His-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-His-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-Leu-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-Leu-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
Succinyl-Ala-Phe-(cis)-Pro-Phe 4-nitroanilide
Succinyl-Ala-Phe-(trans)-Pro-Phe 4-nitroanilide
show the reaction diagram
-
-
-
?
additional information
?
-
-
catalyzes the refolding of type III collagen
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cyclosporin A
-
-
FK506
-
only one of the 4 domains can be inhibited by the immunosuppressive drug
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PPIB_CHICK
207
0
22413
Swiss-Prot
Secretory Pathway (Reliability: 2)
PPIL3_CHICK
161
0
18052
Swiss-Prot
other Location (Reliability: 1)
A0A3Q2TYE1_CHICK
165
0
18229
TrEMBL
other Location (Reliability: 1)
Q90ZG0_CHICK
108
0
11973
TrEMBL
other Location (Reliability: 2)
Q90ZK7_CHICK
227
0
25032
TrEMBL
other Location (Reliability: 2)
E1C3R0_CHICK
505
0
58831
TrEMBL
other Location (Reliability: 5)
A0A1D5PW44_CHICK
166
0
18096
TrEMBL
other Location (Reliability: 3)
D0EKR3_CHICK
165
0
17810
TrEMBL
other Location (Reliability: 2)
F1NIM4_CHICK
442
0
50445
TrEMBL
other Location (Reliability: 1)
Q5ZKV1_CHICK
336
2
37286
TrEMBL
other Location (Reliability: 1)
A0A1D5NYW5_CHICK
99
1
10977
TrEMBL
other Location (Reliability: 5)
A0A3Q2U5K7_CHICK
134
0
15116
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q3B0L8_CHICK
448
0
51157
TrEMBL
other Location (Reliability: 1)
A0A3Q2U9F1_CHICK
298
0
33658
TrEMBL
other Location (Reliability: 3)
F1NCD7_CHICK
125
0
13182
TrEMBL
other Location (Reliability: 1)
E1BXG0_CHICK
177
0
19205
TrEMBL
other Location (Reliability: 2)
A0A1D5P3I6_CHICK
586
0
62841
TrEMBL
Mitochondrion (Reliability: 3)
E1C487_CHICK
210
1
23839
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5PYB9_CHICK
1151
0
126477
TrEMBL
other Location (Reliability: 1)
Q9PRM1_CHICK
32
0
3636
TrEMBL
other Location (Reliability: 3)
A0A3Q2UMI4_CHICK
178
0
19969
TrEMBL
other Location (Reliability: 1)
Q5ZJT4_CHICK
442
0
50431
TrEMBL
other Location (Reliability: 1)
A0A3Q2U9P1_CHICK
464
0
52818
TrEMBL
other Location (Reliability: 1)
I6WF69_CHICK
148
0
15809
TrEMBL
Secretory Pathway (Reliability: 2)
Q9YIC3_CHICK
577
0
64054
TrEMBL
Secretory Pathway (Reliability: 1)
Q8QGU2_CHICK
108
0
11957
TrEMBL
other Location (Reliability: 1)
Q5ZMJ0_CHICK
204
0
21707
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q2TXF9_CHICK
658
0
70408
TrEMBL
other Location (Reliability: 1)
A0A3Q3A9L2_CHICK
142
0
15735
TrEMBL
Secretory Pathway (Reliability: 3)
Q646T7_CHICK
449
0
50427
TrEMBL
other Location (Reliability: 1)
A0A1D5PDE7_CHICK
321
0
35500
TrEMBL
other Location (Reliability: 2)
A0A1D5P8N6_CHICK
107
0
12067
TrEMBL
other Location (Reliability: 2)
F1NRA1_CHICK
294
0
33145
TrEMBL
other Location (Reliability: 4)
A0A1L1RRN4_CHICK
223
1
24308
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q2UM37_CHICK
184
0
20493
TrEMBL
other Location (Reliability: 5)
E1C6R4_CHICK
409
1
44326
TrEMBL
other Location (Reliability: 1)
Q5ZM56_CHICK
321
0
36739
TrEMBL
other Location (Reliability: 3)
R4GH26_CHICK
564
0
62354
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1D5PZU7_CHICK
162
0
18101
TrEMBL
other Location (Reliability: 2)
A0A1D5NY55_CHICK
147
0
15722
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q3A2N8_CHICK
686
0
72994
TrEMBL
Mitochondrion (Reliability: 4)
A0A1D5NWE1_CHICK
319
0
35669
TrEMBL
other Location (Reliability: 4)
A0A1D5PYB1_CHICK
583
0
64372
TrEMBL
Secretory Pathway (Reliability: 1)
F1NNV4_CHICK
1250
0
137076
TrEMBL
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
68000
-
x * 68000, SDS-PAGE under reducing conditions and under nonreducing conditions
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
x * 68000, SDS-PAGE under reducing conditions and under nonreducing conditions
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zeng, B.; MacDonald, J.R.; Bann, J.G.; Beck, K.; Gambee, J.E.; Boswell, B.A.
Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506
Biochem. J.
330
109-114
1998
Gallus gallus
Manually annotated by BRENDA team