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Information on EC 4.6.1.1 - adenylate cyclase and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylate cyclase, adenylyl cyclase, adenyl cyclase, pituitary adenylate cyclase, edema factor, adenylylcyclase, soluble adenylyl cyclase, adenylate cyclase toxin, adcy5, aciii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3',5'-cyclic AMP synthetase
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-
-
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AC2
-
-
-
-
AC3
-
-
-
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ACTP10
-
-
-
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adenyl cyclase
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-
-
-
Adenylate cyclase, olfactive type
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-
-
-
adenylyl cyclase
Adenylyl cyclase type 10
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-
-
-
adenylylcyclase
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-
-
-
ATP pyrophosphate-lyase
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-
-
-
Ca(2+)-inhibitable adenylyl cyclase
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-
-
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Ca(2+)/calmodulin activated adenylyl cyclase
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-
-
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class III AC
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class III adenylyl cyclase
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cyclase, adenylate
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-
-
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Edema factor
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-
-
-
Rutabaga protein
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-
-
-
xlAC
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P-O bond cleavage
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-42-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
MDL-12330A
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the adenylate cyclase inhibitor depresses the response in GRNs to trehalose as well as sucrose in gustatory receptor neurons
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
forskolin
-
activation
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
gustatory receptor neurons
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CYA1_DROME
2248
11
248824
Swiss-Prot
other Location (Reliability: 4)
ACXE_DROME
1123
12
128918
Swiss-Prot
other Location (Reliability: 3)
AC78C_DROME
1718
10
189013
Swiss-Prot
other Location (Reliability: 1)
ADCY2_DROME
1307
10
142817
Swiss-Prot
other Location (Reliability: 2)
Q9VXU0_DROME
1690
11
186869
TrEMBL
other Location (Reliability: 1)
Q9Y1V0_DROME
1718
10
188975
TrEMBL
other Location (Reliability: 1)
M9PHL3_DROME
2146
11
238408
TrEMBL
other Location (Reliability: 4)
Q9W037_DROME
1111
12
127797
TrEMBL
other Location (Reliability: 3)
Q9NJ94_DROME
1121
12
128767
TrEMBL
other Location (Reliability: 3)
M9PID8_DROME
1727
10
190089
TrEMBL
other Location (Reliability: 1)
Q9VK52_DROME
1114
11
127704
TrEMBL
other Location (Reliability: 2)
M9PD54_DROME
1717
10
188885
TrEMBL
other Location (Reliability: 1)
Q9W038_DROME
1162
10
134411
TrEMBL
other Location (Reliability: 1)
O96306_DROME
1167
12
130381
TrEMBL
other Location (Reliability: 2)
Q2PDU2_DROME
436
6
50295
TrEMBL
Mitochondrion (Reliability: 5)
M9PE08_DROME
506
5
58588
TrEMBL
other Location (Reliability: 1)
E1JIB3_DROME
1050
11
120612
TrEMBL
Secretory Pathway (Reliability: 1)
M9NDN7_DROME
1107
11
127375
TrEMBL
other Location (Reliability: 5)
A8JNU1_DROME
1854
14
203837
TrEMBL
other Location (Reliability: 3)
M9PEP2_DROME
1703
11
188332
TrEMBL
Mitochondrion (Reliability: 4)
Q8IRF5_DROME
1164
12
133110
TrEMBL
other Location (Reliability: 2)
X2JAA1_DROME
394
6
46220
TrEMBL
other Location (Reliability: 5)
Q9V9R3_DROME
1167
12
130395
TrEMBL
other Location (Reliability: 2)
Q9NJ99_DROME
1162
10
134354
TrEMBL
other Location (Reliability: 1)
M9PH04_DROME
684
9
79289
TrEMBL
other Location (Reliability: 3)
M9PG27_DROME
1694
10
186224
TrEMBL
other Location (Reliability: 1)
M9NDD2_DROME
1312
10
143365
TrEMBL
other Location (Reliability: 2)
M9NF12_DROME
447
6
52461
TrEMBL
other Location (Reliability: 5)
M9PH52_DROME
1507
11
166457
TrEMBL
other Location (Reliability: 4)
M9NF51_DROME
2055
11
228592
TrEMBL
other Location (Reliability: 4)
Q8IGU9_DROME
1162
10
134441
TrEMBL
other Location (Reliability: 1)
Q9VK53_DROME
1130
11
129845
TrEMBL
Mitochondrion (Reliability: 5)
M9PJN1_DROME
2171
11
241360
TrEMBL
other Location (Reliability: 4)
D3DMC8_DROME
744
5
81976
TrEMBL
other Location (Reliability: 1)
Q9VK51_DROME
1112
11
127938
TrEMBL
other Location (Reliability: 5)
Q9VV68_DROME
1240
12
136770
TrEMBL
other Location (Reliability: 3)
M9PBA8_DROME
865
11
100338
TrEMBL
other Location (Reliability: 5)
Q95RI9_DROME
341
7
38238
TrEMBL
other Location (Reliability: 2)
M9PEL4_DROME
1391
11
153690
TrEMBL
other Location (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in HEK 293 cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Iourgenko, V.; Kliot, B.; Cann, M.J.; Levin, L.R.
Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX
FEBS Lett.
413
104-108
1997
Drosophila melanogaster
Manually annotated by BRENDA team
Linder, J.U.
Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation
Cell. Mol. Life Sci.
63
1736-1751
2006
Bacillus anthracis, Bordetella pertussis, Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chloroflexus aurantiacus, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Euglena gracilis, Mus musculus, Myxococcus xanthus, Pseudomonas aeruginosa, Rattus norvegicus, Sinorhizobium meliloti, Schizosaccharomyces pombe, Arthrospira platensis, Trypanosoma brucei, Ustilago maydis, Yersinia enterocolitica, Mycobacterium tuberculosis (P9WQ35), Nostoc sp. PCC 7120 = FACHB-418 (Q7A2D9), Nostoc sp. PCC 7120 = FACHB-418 (Q8YMH0), Nostoc sp. PCC 7120 = FACHB-418 (Q8YVS0), Mycobacterium tuberculosis H37Rv (P9WQ35)
Manually annotated by BRENDA team
Ueno, K.; Kidokoro, Y.
Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster
Eur. J. Neurosci.
28
1956-1966
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Ueda, A.; Wu, C.F.
Role of rut adenylyl cyclase in the ensemble regulation of presynaptic terminal excitability: reduced synaptic strength and precision in a Drosophila memory mutant
J. Neurogenet.
23
185-199
2008
Drosophila melanogaster
Manually annotated by BRENDA team