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Anaphylaxis
Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase.
Anaphylaxis
The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase.
Aortic Aneurysm, Abdominal
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.
Asthma
5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States.
Asthma
5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
Asthma
Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma.
Asthma
Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma.
Asthma
Analysis of 927T> C CYSLTRI and -444A > C LTC4S polymorphisms in patients with asthma.
Asthma
Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
Asthma
Association between leukotriene C4 synthase A-444C polymorphism and asthma in Chinese Han population in Beijing.
Asthma
Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans.
Asthma
Association of Leukotriene C4 Synthase A-444C Polymorphism with Asthma and Asthma Phenotypes in Romanian Population.
Asthma
Association of the -1072G/A Polymorphism in the LTC4S Gene with Asthma in an Indian Population.
Asthma
Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan.
Asthma
Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma.
Asthma
Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist.
Asthma
Cysteinyl Leukotriene Receptor 1 and Health Effects of Particulate Exposure in Asthma.
Asthma
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies.
Asthma
Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis.
Asthma
Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity.
Asthma
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
Asthma
Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphism.
Asthma
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Asthma
Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma.
Asthma
Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis.
Asthma
Genetic mechanism of aspirin-induced urticaria/angioedema.
Asthma
Implications of pharmacogenomics in the current and future treatment of asthma.
Asthma
Lack of an association between a newly identified promoter polymorphism (-1702G > A) of the leukotriene C4 synthase gene and aspirin-intolerant asthma in a Korean population.
Asthma
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Asthma
Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma.
Asthma
Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma.
Asthma
Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma.
Asthma
Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.
Asthma
Leukotriene generation and clinical implications.
Asthma
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.
Asthma
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase.
Asthma
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.
Asthma
LTC4 synthase. Enzymology, biochemistry, and molecular characterization.
Asthma
Molecular cloning and expression of human leukotriene-C4 synthase.
Asthma
Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.
Asthma
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.
Asthma
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Asthma
Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
Asthma
Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene.
Asthma
The -444A/C Polymorphism in the LTC4S Gene and Risk of Asthma: Meta-analysis.
Asthma
The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors.
Asthma
Uncertain biologic relevance of polymorphisms of leukotriene C4 synthase in asthma.
Asthma
[Relationship between the efficacy of inhaled corticosteroids and the leukotriene expression in children with asthma]
Asthma, Aspirin-Induced
Aspirin-induced rhinitis and asthma.
Asthma, Aspirin-Induced
Leukotriene C4 synthase polymorphism and aspirin-induced asthma.
Asthma, Aspirin-Induced
Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.
Asthma, Aspirin-Induced
Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma.
Asthma, Aspirin-Induced
Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.
Asthma, Aspirin-Induced
Pathogenesis of nonsteroidal antiinflammatory drug-induced asthma.
Asthma, Exercise-Induced
Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA).
Asthma, Exercise-Induced
The leukotriene C4 synthase (A-444C) promoter polymorphism is associated with the severity of exercise-induced asthma in Korean children.
Atherosclerosis
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Blast Crisis
Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate.
Bronchial Hyperreactivity
LTC4 synthase. Enzymology, biochemistry, and molecular characterization.
Bronchial Hyperreactivity
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.
Bronchitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Cardiovascular Diseases
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Cardiovascular Diseases
Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals.
Cerebrovascular Disorders
Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease.
Dermatitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Eosinophilia
Molecular and cellular staging for the severity of chronic rhinosinusitis.
Gastroesophageal Reflux
Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis.
Glomerulonephritis
Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.
Glomerulonephritis
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
Hepatitis
[Gene expressions of LTC4 synthase homologs in Con A-induced mouse hepatitis and regulative effect of cyclosporine A]
Hyperlipidemias
Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.
Hypersensitivity
Specific induction of LTC4 synthase by retinoic acid in rat basophilic leukemia-1 cells.
Ischemic Attack, Transient
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Ischemic Stroke
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China.
Ischemic Stroke
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Leukemia
Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells.
Leukemia
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.
Leukemia
Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone.
Leukemia
Inhibition of leukotriene synthesis by azelastine.
Leukemia
Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells.
Leukemia
Leukotriene C4 synthase from rat basophilic leukemia cell microsomes.
Leukemia
Photoaffinity labelling of human leukotriene C4 synthase in THP-1 cell membranes.
Leukemia
Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells.
Leukemia
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
Leukemia
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
Leukemia, Erythroblastic, Acute
Induction of leukotriene C4 synthase activity in differentiating human erythroleukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inverse relationship between myeloid maturation and leukotriene C4 synthase expression in normal and leukemic myelopoiesis-consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemia.
Leukemia, Myeloid
[Identification of acute leukemia-specific genes from leukemia recipient/sibling donor pairs by distinguishing study with oligonucleotide microarrays]
Lung Diseases, Obstructive
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Mastocytoma
Leukotriene C4 synthase: characterization in mouse mastocytoma cells.
Melanoma
Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4.
Mucocutaneous Lymph Node Syndrome
Gene Polymorphism of Aspirin-Induced Urticaria in Children With Kawasaki Disease.
Myocardial Ischemia
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Nasal Polyps
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Neoplasms
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Neoplasms
Effect of lipopolysaccharide and cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.
Neoplasms
Lipopolysaccharide and cytokines modulate leukotriene (LT)B4 and LTC4 production by porcine endometrial endothelial cells.
Neoplasms
Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells.
Nephritis
Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.
Pneumonia
Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation.
Pulmonary Disease, Chronic Obstructive
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Pulmonary Eosinophilia
Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.
Reperfusion Injury
V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-?B activation pathway.
Rhinitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Rhinitis, Allergic
Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis.
Rhinitis, Allergic
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Sinusitis
Advances in upper airway diseases and allergen immunotherapy.
Sinusitis
Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis.
Tachycardia
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis.
Urticaria
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant.
Urticaria
Gene Polymorphism of Aspirin-Induced Urticaria in Children With Kawasaki Disease.
Urticaria
The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria.
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A444C
-
the mutation is associated with the risk of ischemic cerebrovascular disease
A52S
-
mutation increases the Km-value for the recombinant enzyme for glutathione
C56S/C82
-
mutant enzyme without altered function
C82V
-
mutant enzyme without altered function
E4K
causes allergic diseases in patients such as bronchial asthma or allergic dermatitis
G1072A
-
the mutation is associated with the risk of ischemic cerebrovascular disease
L121M
by site-directed mutagenesis to prepare the selenomethionine-substituted LTC4S, the mutant yeast clone is grown with selenomethionine, purified and crystallized similarly to the wild-type enzyme
LTCS(1-115)
C-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(1-24)
C-terminally truncated protein, gives no bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(1-58)
C-terminally truncated protein, gives no bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(1-88)
C-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(114-150)
N-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(23-115)
C- and N-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(23-150)
N-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(57-150)
N-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
LTCS(87-150)
N-terminally truncated protein, gives a bioluminescence resonance energy transfer signal when fused to Renilla luciferase
N55A
-
mutation increases the Km-value for the recombinant enzyme for glutathione
R104K
0.1% of wild-type activity
R104Q
substrate leukotriene A4, 2% of wild-type activity. No activity with substrate leukotriene A4 methyl ester
R104S
4.6% of wild-type activity
R104T
1.1% of wild-type activity
R113A
substrate leukotriene A4, 140% of wild-type activity
R113Q
substrate leukotriene A4, 150% of wild-type activity
R31E
substrate leukotriene A4, 3% of wild-type activity
R31L
substrate leukotriene A4, 3% of wild-type activity
R51A
57% of wild-type activity
R51H
-
fully active mutant enzyme
R51K
-
fully active mutant enzyme
R51Q
29% of wild-type activity
R51T
-
mutant enzyme without activity
R90A
substrate leukotriene A4, 6% of wild-type activity, substrate leukotriene A4 methyl ester, 21% ot wild-type activity
R90Q
substrate leukotriene A4, about 20% of wild-type activity
R92A
substrate leukotriene A4, about 95% of wild-type activity
R92Q
substrate leukotriene A4, about 105% of wild-type activity
R99A
substrate leukotriene A4, about 100% of wild-type activity
R99Q
substrate leukotriene A4, about 70% of wild-type activity
S36E
phosphomimetic mutant, displays about 20 % of wild-type activity. Mutant shows poor lipid substrate binding
T40E
phosphomimetic mutant, activity is hardly affected
V49F
-
mutation increases the Km-value for the recombinant enzyme for glutathione
W116A
site-directed mutagenesis, altered kinetics compared to the wild-type enzyme
W116F
site-directed mutagenesis, the mutant shows a 3fold increased turnover of leukotriene A4 compared to the wild-type enzyme
Y59F
-
mutation increases the Km-value for the recombinant enzyme for glutathione
Y97F
-
mutation increases the Km-value for the recombinant enzyme for glutathione
C56S
-
mutant enzyme without altered function
C56S
not inhibited by N-ethylmaleimide
R104A
5.7% of wild-type activity
R104A
substrate leukotriene A4, 2% of wild-type activity. No activity with substrate leukotriene A4 methyl ester
R31A
12% of wild-type activity
R31A
substrate leukotriene A4, 6% of wild-type activity. No activity with substrate leukotriene A4 methyl ester
R31Q
30% of wild-type activity
R31Q
substrate leukotriene A4, 32% of wild-type activity
R51I
inactive
R51I
-
mutant enzyme without activity
Y93F
-
mutation increases the Km-value for the recombinant enzyme for glutathione
Y93F
-
activity of the mutant enzyme is less than 1% of the wild-type enzyme, shift in pH optimum of the residual activity to that of spontaneous conjugation
Y93F
reduces the enzyme activity to less than 1% of the wild-type enzyme, shift in the pH-optimum
additional information
-
the LTC4S2 variant in LTC4 confers a 1.807fold increase in stroke when present at 2 copies, whereas the LTBR_2 variant in the LTB4R/LTB4R2 gene region confers a 1.671fold increase in stroke risk when present at 1 or more copies, LTBR_2 and LTBR_6, confer relative risks of 2.371 and 2.081 in cardioembolic stroke, variants in leukotriene C4 synthase confer a 1.5fold increase in risk of small vessel disease
additional information
-
resequencing the gene coding for leukotriene C4 synthase in an population with extreme risk of venous thromboembolism, ischemic stroke and myocardial infarction, among more than 1500 individuals, reveals 17 unknown mutations, of which four are likely to change protein function, i.e. 211G>A, with minor allele frequency, IVS3 + 1G>A, 374G>A and 451_453+10del. Age and sex adjusted odds ratios for venous thromboembolism are 2.0 for IVS3+1G>A heterozygotes versus wild-type, and 1.9 for any mutation heterozygote versus wild-type. Corresponding values are 2.0 and 1.5 for ischemic stroke, and 1.0 and 1.2 for myocardial infarction
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Sala, A.; Garcia, M.; Zarini, S.; Rossi, J.C.; Folco, G.; Durand, T.
14,15-dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase
Biochem. J.
328
225-229
1997
Homo sapiens
-
brenda
Penrose, J.F.
LTC4 synthase: Enzymology, biochemistry, and molecular characterization
Clin. Rev. Allergy Immunol.
17
133-152
1999
Homo sapiens
brenda
Penrose, J.F.; Austen, K.F.
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase
Proc. Assoc. Am. Phys.
111
537-546
1999
Cavia porcellus, Homo sapiens, Mus musculus
-
brenda
Sjostrom, M.; Jakobsson, P.J.; Juremalm, M.; Ahmed, A.; Nilsson, G.; Macchia, L.; Haeggstrom, J.Z.
Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor
Biochim. Biophys. Acta
1583
53-62
2002
Homo sapiens
brenda
Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.
Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase
Biochim. Biophys. Acta
1391
157-168
1998
Homo sapiens
brenda
Christmas, P.; Weber, B.M.; McKee, M.; Brown, D.; Soberman, R.J.
Membrane localization and topology of leukotriene C4 synthase
J. Biol. Chem.
277
28902-28908
2002
Homo sapiens
brenda
Nicholson, D.W.; Ali, A.; Vaillancourt, J.P.; Calaycay, J.R.; Mumford, R.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits
Proc. Natl. Acad. Sci. USA
90
2015-2019
1993
Homo sapiens
brenda
Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells
J. Biol. Chem.
267
17849-17857
1992
Homo sapiens, Rattus norvegicus
brenda
Soederstroem, M.; Morgenstern, R.; Hammarstroem, S.
Protein-protein interaction affinity chromatography of leukotriene C4 synthase
Protein Expr. Purif.
6
352-356
1995
Homo sapiens, Mus musculus
brenda
Goppelt-Struebe, M.
Two step purification of human and murine leukotriene C4 synthase
Biochim. Biophys. Acta
1256
257-261
1995
Homo sapiens, Mus musculus
brenda
Sderstrm, M.; Mannervik, B.; Garkov, V.; Hammarstrm, S.
On the nature of leukotriene C4 synthase in human platelets
Arch. Biochem. Biophys.
294
70-74
1992
Homo sapiens
brenda
Lam, B.K.; Frank Austen, K.
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes
Prostaglandins Other Lipid Mediat.
68-69
511-520
2002
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Tornhamre, S.; Sjolinder, M.; Lindberg, A.; Ericsson, I.; Nasman-Glaser, B.; Griffiths, W.J.; Lindgren, J.A.
Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity
Eur. J. Biochem.
251
227-235
1998
Bos taurus, Equus caballus, Homo sapiens, no activity in Sus scrofa, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
brenda
Wu, C.
Conversion of leukotrienes A4 to C4 in cell-free systems
Biochem. Biophys. Res. Commun.
134
85-92
1986
Cavia porcellus, Homo sapiens, Rattus norvegicus
brenda
Penrose, J.F.; Gagnon, L.; Goppelt-Struebe, M.; Myers, P.; Lam, B.K.; Jack, R.M.; Austen, K.F.; Soberman, R.J.
Purification of human leukotriene C4 synthase
Proc. Natl. Acad. Sci. USA
89
11603-11606
1992
Homo sapiens
brenda
Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells
Eur. J. Biochem.
209
725-734
1992
Homo sapiens
brenda
Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.
Molecular cloning, expression and characterization of mouse leukotriene C4 synthase
Eur. J. Biochem.
238
606-612
1996
Homo sapiens, Mus musculus
brenda
Svartz, J.; Blomgran, R.; Hammarstrom, S.; Soderstrom, M.
Leukotriene C4 synthase homo-oligomers detected in living cells by bioluminescence resonance energy transfer
Biochim. Biophys. Acta
1633
90-95
2003
Homo sapiens (Q16873), Homo sapiens
brenda
Yoshikawa, K.; Matsui, E.; Kaneko, H.; Fukao, T.; Inoue, R.; Teramoto, T.; Shinoda, S.; Fukutomi, O.; Aoki, M.; Kasahara, K.; Kondo, N.
A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases
Int. J. Mol. Med.
16
827-831
2005
Homo sapiens (Q16873), Homo sapiens
brenda
Zaitsu, M.; Hamasaki, Y.; Matsuo, M.; Ichimaru, T.; Fujita, I.; Ishii, E.
Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children
J. Asthma
40
147-154
2003
Homo sapiens (Q16873), Homo sapiens
brenda
Mansour, M.; Tornhamre, S.
Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone
J. Enzyme Inhib. Med. Chem.
19
431-436
2004
Homo sapiens (Q16873), Homo sapiens
brenda
Mandal, A.K.; Skoch, J.; Bacskai, B.J.; Hyman, B.T.; Christmas, P.; Miller, D.; Yamin, T.t.D.; Xu, S.; Wisniewski, D.; Evans, J.F.; Soberman, R.J.
The membrane organization of leukotriene synthesis
Proc. Natl. Acad. Sci. USA
101
6587-6592
2004
Homo sapiens (Q16873)
brenda
Lam, B.K.
Leukotriene C4 synthase
Prostaglandins Leukot. Essent. Fatty Acids
69
111-116
2003
Homo sapiens (Q16873)
brenda
Schmidt-Krey, I.; Kanaoka, Y.; Mills, D.J.; Irikura, D.; Haase, W.; Lam, B.K.; Austen, K.F.; Kuehlbrandt, W.
Human leukotriene C4 synthase at 4.5.ANG. resolution in projection
Structure
12
2009-2014
2004
Homo sapiens (Q16873)
brenda
Serio, K.J.; Luo, C.; Luo, L.; Mao, J.T.
TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes
Am. J. Physiol.
292
L215-L222
2007
Homo sapiens (Q16873), Homo sapiens
brenda
Mastalerz, L.; Setkowicz, M.; Sanak, M.; Rybarczyk, H.; Szczeklik, A.
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant
Br. J. Dermatol.
154
256-260
2006
Homo sapiens (Q16873), Homo sapiens
brenda
Jame, A.J.; Lackie, P.M.; Cazaly, A.M.; Sayers, I.; Penrose, J.F.; Holgate, S.T.; Sampson, A.P.
Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
Clin. Exp. Allergy
37
880-892
2007
Homo sapiens (Q16873), Homo sapiens
brenda
Svartz, J.; Hallin, E.; Shi, Y.; Soederstroem, M.; Hammarstroem, S.
Identification of regions of leukotriene C4 synthase which direct the enzyme to its nuclear envelope localization
J. Cell. Biochem.
98
1517-1527
2006
Homo sapiens (Q16873), Homo sapiens
brenda
Ago, H.; Kanaoka, Y.; Irikura, D.; Lam, B.K.; Shimamura, T.; Austen, K.F.; Miyano, M.
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
Nature
448
609-612
2007
Homo sapiens (Q16873), Homo sapiens
brenda
Martinez Molina, D.; Wetterholm, A.; Kohl, A.; McCarthy, A.A.; Niegowski, D.; Ohlson, E.; Hammarberg, T.; Eshaghi, S.; Haeggstroem, J.Z.; Nordlund, P.
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase
Nature
448
613-616
2007
Homo sapiens (Q16873), Homo sapiens
brenda
Freiberg, J.J.; Tybjaerg-Hansen, A.; Sillesen, H.; Jensen, G.B.; Nordestgaard, B.G.
Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
Arterioscler. Thromb. Vasc. Biol.
28
990-996
2008
Homo sapiens
brenda
Sveinbjoernsson, B.; Rasmuson, A.; Baryawno, N.; Wan, M.; Pettersen, I.; Ponthan, F.; Orrego, A.; Haeggstroem, J.Z.; Johnsen, J.I.; Kogner, P.
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
FASEB J.
22
3525-3536
2008
Homo sapiens
brenda
Bevan, S.; Dichgans, M.; Wiechmann, H.E.; Gschwendtner, A.; Meitinger, T.; Markus, H.S.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
Stroke
39
1109-1114
2008
Homo sapiens
brenda
Strid, T.; Svartz, J.; Franck, N.; Hallin, E.; Ingelsson, B.; Soederstroem, M.; Hammarstroem, S.
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein
Biochem. Biophys. Res. Commun.
381
518-522
2009
Homo sapiens (Q16873)
brenda
Westergren, V.S.; Wilson, S.J.; Penrose, J.F.; Howarth, P.H.; Sampson, A.P.
Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis
Clin. Exp. Allergy
39
820-828
2009
Homo sapiens (Q16873)
brenda
Steinke, J.W.; Culp, J.A.; Kropf, E.; Borish, L.
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
J. Allergy Clin. Immunol.
124
724-730
2009
Homo sapiens (Q16873)
brenda
Newcomer, M.E.; Gilbert, N.C.
Location, location, location: compartmentalization of early events in leukotriene biosynthesis
J. Biol. Chem.
285
25109-25114
2010
Homo sapiens (Q16873)
brenda
Sanchez-Borges, M.; Acevedo, N.; Vergara, C.; Jimenez, S.; Zabner-Oziel, P.; Monzon, A.; Caraballo, L.
The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria
J. Investig. Allergol. Clin. Immunol.
19
375-382
2009
Homo sapiens
brenda
Freiberg, J.J.; Dahl, M.; Tybjaerg-Hansen, A.; Grande, P.; Nordestgaard, B.G.
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
J. Mol. Cell. Cardiol.
46
579-586
2009
Homo sapiens (Q16873), Homo sapiens
brenda
Zhao, G.; Johnson, M.C.; Schnell, J.R.; Kanaoka, Y.; Haase, W.; Irikura, D.; Lam, B.K.; Schmidt-Krey, I.
Two-dimensional crystallization conditions of human leukotriene C4 synthase requiring adjustment of a particularly large combination of specific parameters
J. Struct. Biol.
169
450-454
2010
Homo sapiens
brenda
Esser, J.; Gehrmann, U.; Salvado, M.D.; Wetterholm, A.; Haeggstroem, J.Z.; Samuelsson, B.; Gabrielsson, S.; Scheynius, A.; Radmark, O.
Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors
FASEB J.
25
1417-1427
2011
Homo sapiens
brenda
Rinaldo-Matthis, A.; Wetterholm, A.; Martinez Molina, D.; Holm, J.; Niegowski, D.; Ohlson, E.; Nordlund, P.; Morgenstern, R.; Haeggstroem, J.Z.
Arginine 104 is a key catalytic residue in leukotriene C4 synthase
J. Biol. Chem.
285
40771-40776
2010
Homo sapiens (Q16873), Homo sapiens
brenda
Saino, H.; Ukita, Y.; Ago, H.; Irikura, D.; Nisawa, A.; Ueno, G.; Yamamoto, M.; Kanaoka, Y.; Lam, B.K.; Austen, K.F.; Miyano, M.
The catalytic architecture of leukotriene C4 synthase with two arginine residues
J. Biol. Chem.
286
16392-16401
2011
Homo sapiens (Q16873)
brenda
Freiberg, J.J.; Tybjaerg-Hansen, A.; Nordestgaard, B.G.
Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals
J. Thromb. Haemost.
8
1694-1701
2010
Homo sapiens
brenda
Di Gennaro, A.; Wagsaeter, D.; Maeyraenpaeae, M.I.; Gabrielsen, A.; Swedenborg, J.; Hamsten, A.; Samuelsson, B.; Eriksson, P.; Haeggstroem, J.Z.
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm
Proc. Natl. Acad. Sci. USA
107
21093-21097
2010
Homo sapiens
brenda
Niegowski, D.; Kleinschmidt, T.; Olsson, U.; Ahmad, S.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism
J. Biol. Chem.
289
5199-5207
2014
Homo sapiens (Q16873), Homo sapiens
brenda
MacDonald, C.A.; Bushnell, E.A.; Gauld, J.W.; Boyd, R.J.
The catalytic formation of leukotriene C4: a critical step in inflammatory processes
Phys. Chem. Chem. Phys.
16
16284-16289
2014
Homo sapiens
brenda
Liening, S.; Scriba, G.K.; Rummler, S.; Weinigel, C.; Kleinschmidt, T.K.; Haeggstroem, J.Z.; Werz, O.; Garscha, U.
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors
Biochim. Biophys. Acta
1861
1605-1613
2016
Homo sapiens (Q16873)
brenda
Ahmad, S.; Ytterberg, A.J.; Thulasingam, M.; Tholander, F.; Bergman, T.; Zubarev, R.; Wetterholm, A.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Phosphorylation of leukotriene C4 synthase at serine 36 impairs catalytic activity
J. Biol. Chem.
291
18410-18418
2016
Homo sapiens (Q16873)
brenda
Kleinschmidt, T.K.; Haraldsson, M.; Basavarajappa, D.; Lundeberg, E.; Thulasingam, M.; Ekoff, M.; Fauland, A.; Lehmann, C.; Kahnt, A.S.; Lindbom, L.; Haeggstroem, J.Z.
Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase
J. Pharmacol. Exp. Ther.
355
108-116
2015
Homo sapiens (Q16873), Homo sapiens
brenda