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Information on EC 4.3.1.17 - L-serine ammonia-lyase and Organism(s) Pseudomonas aeruginosa

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.17 L-serine ammonia-lyase
IUBMB Comments
Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead . The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC 4.3.1.19, threonine ammonia-lyase, from a number of sources.
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Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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Synonyms
serine dehydratase, l-serine dehydratase, l-threonine deaminase, l-threonine dehydratase, l-serine deaminase, serine deaminase, serdh, lplsd, l-sd2, msmeg_3532, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Dehydratase, L-serine
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L-Hydroxy amino acid dehydratase
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L-SD
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L-SD1
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L-SD2
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L-Serine deaminase
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SD
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SDH
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Serine deaminase
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Serine dehydratase
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SYSTEMATIC NAME
IUBMB Comments
L-serine ammonia-lyase (pyruvate-forming)
Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead [6]. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC 4.3.1.19, threonine ammonia-lyase, from a number of sources.
CAS REGISTRY NUMBER
COMMENTARY hide
9014-27-1
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8G7IHF7_PSEAI
458
0
49203
TrEMBL
-
A0A8G3ZTZ4_PSEAI
458
0
49164
TrEMBL
-
A0A6B1YJS1_PSEAI
458
0
49044
TrEMBL
-
A0A3M5EF07_PSEAI
42
0
4382
TrEMBL
-
A0A6A9JXC3_PSEAI
458
0
49301
TrEMBL
-
A0A485EY33_PSEAI
469
0
50029
TrEMBL
-
A0A8G3W423_PSEAI
458
0
48958
TrEMBL
-
A0A8G5NML6_PSEAI
458
0
49170
TrEMBL
-
A0A241XFF2_PSEAI
458
0
49247
TrEMBL
-
A0A0A8RNS1_PSEAI
458
0
48997
TrEMBL
-
A0A2R3IQ73_PSEAI
458
0
48927
TrEMBL
-
A0A8G3Y9X0_PSEAI
458
0
48901
TrEMBL
-
A0A8G6HN42_PSEAI
458
0
48928
TrEMBL
-
A0A0C6FE09_PSEAI
458
0
49217
TrEMBL
-
A0A8F9NMZ1_PSEAI
458
0
48998
TrEMBL
-
A0A8G7PKV6_PSEAI
458
0
49243
TrEMBL
-
A0A8G7PS75_PSEAI
458
0
49187
TrEMBL
-
A0A8H0WZP3_PSEAI
458
0
49249
TrEMBL
-
A0A0A8RG54_PSEAI
485
0
52213
TrEMBL
-
A0A8B5AUL1_PSEAI
458
0
49231
TrEMBL
-
A0A8G7PJJ0_PSEAI
457
0
48814
TrEMBL
-
A0A0Q1KNA2_PSEAI
458
0
48929
TrEMBL
-
A0A4P0UI75_PSEAI
93
0
10044
TrEMBL
-
A0A8G3SHU1_PSEAI
458
0
48928
TrEMBL
-
A0A8I1D136_PSEAI
458
0
49279
TrEMBL
-
A0A8G3ZKY8_PSEAI
458
0
49284
TrEMBL
-
A0A8G5V3Z2_PSEAI
458
0
48912
TrEMBL
-
A0A8F9KH33_PSEAI
458
0
49302
TrEMBL
-
A0A8G5MXT8_PSEAI
458
0
48959
TrEMBL
-
A0A8G2V665_PSEAI
458
0
49275
TrEMBL
-
A0A367M0H9_PSEAI
302
0
32487
TrEMBL
-
A0A8G4YL50_PSEAI
458
0
49233
TrEMBL
-
A0A5K1S3N9_PSEAI
458
0
48931
TrEMBL
-
A0A5F1BNU8_PSEAI
458
0
48957
TrEMBL
-
A0A643IXD0_PSEAI
458
0
48928
TrEMBL
-
A0A8G1NCA7_PSEAI
458
0
48986
TrEMBL
-
A0A8G4YIX8_PSEAI
458
0
48876
TrEMBL
-
A0A8G3EET9_PSEAI
458
0
48973
TrEMBL
-
A0A8G2YDU4_PSEAI
458
0
48986
TrEMBL
-
A0A8G6VCC8_PSEAI
458
0
48945
TrEMBL
-
A0A8G3Q4Q6_PSEAI
458
0
48941
TrEMBL
-
A0A5E9JU64_PSEAI
458
0
48956
TrEMBL
-
A0A8G2RE17_PSEAI
458
0
48929
TrEMBL
-
A0A8G1V858_PSEAI
456
0
48933
TrEMBL
-
A0A0A8RPM2_PSEAI
364
0
38796
TrEMBL
-
A0A8G7DD67_PSEAI
29
0
3034
TrEMBL
-
A0A8G6YGR6_PSEAI
458
0
49275
TrEMBL
-
A0A3S0S4X1_PSEAI
458
0
48941
TrEMBL
-
A0A4P0UJW7_PSEAI
393
0
41897
TrEMBL
-
A0A8G2YMF8_PSEAI
458
0
48970
TrEMBL
-
A0A8G2YES6_PSEAI
458
0
49190
TrEMBL
-
A0A8G6RBY3_PSEAI
458
0
48943
TrEMBL
-
A0A2R3IM89_PSEAI
458
0
49189
TrEMBL
-
A0A8G4HLB2_PSEAI
458
0
49187
TrEMBL
-
A0A8G2R9Z0_PSEAI
458
0
49236
TrEMBL
-
A0A367LU77_PSEAI
60
0
6196
TrEMBL
-
A0A3M5ELS4_PSEAI
458
0
49273
TrEMBL
-