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(6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate
6-fluorochorismate + phosphate
-
converion rate between 270 and 370 times slower than natural substrate conversion
-
-
?
(6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate
6-fluorochorismate + phosphate
-
?
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
5-enolpyruvylshikimate-3-phosphate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
additional information
?
-
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
last enzyme of the shikimate pathway, catalyzes the anti-1,4-elimination of the 3-phosphate group and the C-(6proR) hydrogen from 5-enolpyruvylshikimate 3-phosphate
chorismate is a precursor for the biosynthesis of aromatic compounds
-
r
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme of the shikimate pathway, catalyzes the NADH- and FMN-dependent synthesis of chorismate, a precursor of aromatic amino acids, naphthoquinones, menaquinones, and mycobactins
-
-
r
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
-
?
FMN + NADPH
?
-
-
-
-
?
FMN + NADPH
?
-
recombinant enzyme has a diaphorase activity. NADPH binds in or near the substrate (O5-(1-carboxyvinyl)-3-phosphoshikimate) binding site, suggesting that NADPH binding to the enzyme is embedded in the general protein structure and a special NADPH binding domain is not required to generate the intrinsic oxidoreductase activity
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
5-enolpyruvylshikimate 3-phosphate
-
ir
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
5-enolpyruvylshikimate 3-phosphate
-
ir
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
5-enolpyruvylshikimate 3-phosphate
-
ir
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
evidence for a radical mechanism
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
secondary beta deuterium kinetic isotope effect
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
enzyme of the shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
last step of shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
5-enolpyruvylshikimate 3-phosphate
-
ir
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
secondary beta deuterium kinetic isotope effect
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
enzyme of the shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
last step in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
5-enolpyruvylshikimate 3-phosphate
-
ir
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
enzyme is involved in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
5-enolpyruvylshikimate 3-phosphate
-
ir
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme of shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
the enzyme catalyzes the final step of shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
enzyme of the shikimate pathway
-
?
additional information
?
-
enzyme has flavin reductase activity
-
?
additional information
?
-
no flavin reductase activity
-
?
additional information
?
-
-
no flavin reductase activity
-
?
additional information
?
-
-
enzyme shows flavin reductase activity
-
?
additional information
?
-
enzyme shows flavin reductase activity
-
?
additional information
?
-
-
the enzyme also shows FMN:NADPH oxidoreductase activity
-
?
additional information
?
-
-
the dissociation constant for the S127A mutant protein is similar to that of the wild-type enzyme, whereas the replacement of S16 with alanine results in a slight increase of the dissociation constant
-
-
?
additional information
?
-
-
monofunctional enzyme that does not possess an intrinsic flavin reductase activity
-
?
additional information
?
-
-
enzyme shows flavin reductase activity
-
?
additional information
?
-
-
no flavin reductase activity
-
?
additional information
?
-
-
no flavin reductase activity
-
?
additional information
?
-
monofunctional enzyme that does not have an intrinsic ability to reduce the FMN cofactor
-
?
additional information
?
-
-
monofunctional enzyme that does not have an intrinsic ability to reduce the FMN cofactor
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
5-enolpyruvylshikimate-3-phosphate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
additional information
?
-
-
the dissociation constant for the S127A mutant protein is similar to that of the wild-type enzyme, whereas the replacement of S16 with alanine results in a slight increase of the dissociation constant
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
last enzyme of the shikimate pathway, catalyzes the anti-1,4-elimination of the 3-phosphate group and the C-(6proR) hydrogen from 5-enolpyruvylshikimate 3-phosphate
chorismate is a precursor for the biosynthesis of aromatic compounds
-
r
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-enolpyruvylshikimate 3-phosphate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
?
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme of the shikimate pathway, catalyzes the NADH- and FMN-dependent synthesis of chorismate, a precursor of aromatic amino acids, naphthoquinones, menaquinones, and mycobactins
-
-
r
5-O-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
?
-
-
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
enzyme of the shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
last step of shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
enzyme of the shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
last step in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
enzyme is involved in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
seventh enzyme of shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
seventh enzyme in shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
-
the enzyme catalyzes the final step of shikimate pathway
-
?
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
enzyme of the shikimate pathway
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.0000021
(17beta)-17-(4-hydroxybenzoyl)androsta-3,5-diene-3-carboxylic acid
pH and temperature not specified in the publication
0.00149
(2E)-5,7-dihydroxy-2-[[4-(pyrrolidin-1-yl)phenyl]methylidene]-1-benzofuran-3(2H)-one
pH and temperature not specified in the publication
0.03944
(2E)-5,7-dihydroxy-2-[[4-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3(2H)-one
pH and temperature not specified in the publication
0.01207
(2E)-6,7-dihydroxy-2-([2-hydroxy-4-[(6-hydroxyhexyl)oxy]phenyl]methylidene)-1-benzofuran-3(2H)-one
pH and temperature not specified in the publication
0.00179
(3R,4R,5R)-5-(carboxymethoxy)-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
theoretical Ki value obtained using AUTODOCK software version 4, pH not specified in the publication, temperature not specified in the publication
0.000109
(3R,4S,5R)-4-hydroxy-3-[(2S)-1-hydroxy-1-oxo-2-phosphonooxypropan-2-yl]oxy-5-phosphonooxycyclohexene-1-carboxylic acid
theoretical Ki value obtained using AUTODOCK software version 4, pH not specified in the publication, temperature not specified in the publication
0.000192
(3R,4S,5R)-5-(1-carboxyethoxy)-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
theoretical Ki value obtained using AUTODOCK software version 4, pH not specified in the publication, temperature not specified in the publication
0.000526
(3R,4S,5R)-5-[(1R)-1-carboxy-1-phosphonoethoxy]-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
theoretical Ki value obtained using AUTODOCK software version 4, pH not specified in the publication, temperature not specified in the publication
0.000815
(3R,4S,5S,6S)-5-(1-carboxyethenoxy)-6-fluoro-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
theoretical Ki value obtained using AUTODOCK software version 4, pH not specified in the publication, temperature not specified in the publication
0.00003732
([1,1'-biphenyl]-4-yl)(4-nitrophenyl)methanone
pH and temperature not specified in the publication
0.00000832
1-(naphthalen-2-yl)-2-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]ethan-1-one
pH and temperature not specified in the publication
0.00061
2-difluoro-[1-phosphonooxyethoxy]-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
theoretical Ki value obtained using AUTODOCK software version 4, pH not specified in the publication, temperature not specified in the publication
0.00002294
3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid
pH and temperature not specified in the publication
0.00000061461
4-[(E)-(5,7-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]benzoic acid
pH and temperature not specified in the publication
0.00003336
4-[7-(hydroxymethyl)-1-benzofuran-2-yl]-7-methyl-2-oxo-2H-1-benzopyran-6-yl furan-2-carboxylate
pH and temperature not specified in the publication
0.00001691
4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
pH and temperature not specified in the publication
0.00003809
6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
pH and temperature not specified in the publication
0.03944
CHEMBL135212
pH and temperature not specified in the publication
0.00149
CHEMBL335859
pH and temperature not specified in the publication
0.01207
CHEMBL336282
pH and temperature not specified in the publication
0.00000061461
CHEMBL338732
pH and temperature not specified in the publication
0.00003099
N-(2-benzoyl-3-methyl-1-benzofuran-6-yl)-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanamide
pH and temperature not specified in the publication
0.03584
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
pH and temperature not specified in the publication
0.00001663
N-[2-(4-methoxybenzoyl)-3-methyl-1-benzofuran-5-yl]-2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)acetamide
pH and temperature not specified in the publication
0.00002031
N-[5-(1,1-dioxo-1lambda6,2-thiazolidin-2-yl)-1H-indazol-3-yl]-2-[4-(piperidin-1-yl)phenyl]acetamide
pH and temperature not specified in the publication
0.00001691
ZINC00602427
pH and temperature not specified in the publication
0.00000832
ZINC01163259
pH and temperature not specified in the publication
0.00003809
ZINC01587011
pH and temperature not specified in the publication
0.0000021
ZINC03803450
pH and temperature not specified in the publication
0.00003336
ZINC09708077
pH and temperature not specified in the publication
0.00002294
ZINC13387711
pH and temperature not specified in the publication
0.00003099
ZINC13681793
pH and temperature not specified in the publication
0.00001663
ZINC13682976
pH and temperature not specified in the publication
0.03584
ZINC16052528
pH and temperature not specified in the publication
0.00002031
ZINC20149031
pH and temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Hasan, N.; Nester, E.W.
Dehydroquinate synthase in Bacillus subtilis. An enzyme associated with chorismate synthase and flavin reductase
J. Biol. Chem.
253
4999-5004
1978
Bacillus subtilis
brenda
White, P.J.; Millar, G.; Coggins, J.R.
The overexpression, purification and complete amino acid sequence of chorismate synthase from Escherichia coli K12 and its comparison with the enzyme from Neurospora crassa
Biochem. J.
251
313-322
1988
Escherichia coli, Neurospora crassa
brenda
Gaertner, F.H.
Chorismate synthase: A bifunctional enzyme in Neurospora crassa
Methods Enzymol.
142
362-366
1987
Neurospora crassa
brenda
White, P.J.; Mousdale, D.M.; Coggins, J.R.
A simple anaerobic assay for chorismate synthase
Biochem. Soc. Trans.
15
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