Reference on EC 4.2.3.1 - threonine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flavin, M.; Slaughter, C.
Purification and properties of threonine synthetase of Neurospora
J. Biol. Chem.
235
1103-1108
1960
BRENDA: Neurospora crassa
Textmining: Neurospora
Skarstedt, M.T.; Greer, S.B.
Threonine synthetase of Bacillus subtilis. The nature of an associated dehydratase activity
J. Biol. Chem.
248
1032-1044
1973
Bacillus subtilis
Schildkraut, I.; Greer, S.
Threonine synthetase-catalyzed conversion of phosphohomoserine to alpha-ketobutyrate in Bacillus subtilis
J. Bacteriol.
115
777-785
1973
Bacillus subtilis
Madison, J.T.; Thompson, J.F.
Threonine synthetase from higher plants: stimulation by S-adenosylmethionine and inhibition by cysteine
Biochem. Biophys. Res. Commun.
71
684-691
1976
BRENDA: Beta vulgaris, Raphanus sativus
Textmining: Embryophyta
Thoen, A.; Rognes, S.E.; Aarnes, H.
Biosynthesis of threonine from homoserine in pea seedlings. II. Threonine synthase
Plant Sci. Lett.
13
113-119
1978
Pisum sativum
-
Parsot, C.; Cossart, P.; Saint-Girons, I.; Cohen, G.N.
Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12
Nucleic Acids Res.
11
7331-7345
1983
Escherichia coli
Giovanelli, J.; Veluthambi, K.; Thompson, G.A.; Mudd, S.H.; Datko, A.H.
Threonine synthase of Lemna paucicostata Hegelm. 6746
Plant Physiol.
76
285-292
1984
Lemna aequinoctialis
Shames, S.L.; Ash, D.E.; Wedler, F.C.; Villafranca, J.J.
Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli
J. Biol. Chem.
259
15331-15339
1984
Escherichia coli
Parsot, C.
Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase
EMBO J.
5
3013-3019
1986
BRENDA: Bacillus subtilis
Textmining: Escherichia coli
Giovanelli, J.; Mudd, S.H.; Datko, A.H.; Thompson, G.A.
Effects of orthophosphate and adenosine 5'-phosphate on threonine synthase and cystathionine gamma-synthase of Lemna paucicostata Hegelm. 6746
Plant Physiol.
81
577-583
1986
BRENDA: Lemna aequinoctialis
Textmining: Lemna
Parsot, C.
A common origin for enzymes involved in the terminal step of the threonine and tryptophan biosynthetic pathways
Proc. Natl. Acad. Sci. USA
84
5207-5210
1987
Bacillus subtilis
Curien, G.; Dumas, R.; Ravanel, S.; Douce, R.
Characterization of an Arabidopsis thaliana cDNA encoding an S-adenosylmethionine-sensitive threonine synthase. Threonine synthase from higher plants
FEBS Lett.
390
85-90
1996
BRENDA: Arabidopsis thaliana
Textmining: Embryophyta, Escherichia coli, plant
Malumbres, M.; Mateos, L.M.; Lumbreras, M.A.; Guerrero, C.; Martin, J.F.
Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase
Appl. Environ. Microbiol.
60
2209-2219
1994
Corynebacterium glutamicum
Laber, B.; Maurer, W.; Hanke, C.; Graefe, S.; Ehlert, S.; Messerschmidt, A.; Clausen, T.
Characterization of recombinant Arabidopsis thaliana threonine synthase
Eur. J. Biochem.
263
212-221
1999
Arabidopsis thaliana
Greenberg, J.M.; Thompson, J.F.; Madison, J.T.
Homoserine kinase and threonine synthase in methionine-overproducing soybean tissue cultures
Plant Cell Rep.
7
477-480
1988
Glycine max
Farrington, G.K.; Kumar, A.; Shames, S.L.; Ewaskiewicz, J.I.; Ash, D.A.; Wedler, F.C.
Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate
Arch. Biochem. Biophys.
307
165-174
1993
Escherichia coli
Laber, B.; Gerbling, K.P.; Harde, C.; Neff, K.H.; Nordhoff, E.; Pohlenz, H.D.
Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors
Biochemistry
33
3413-3423
1994
Escherichia coli
Curien, G.; Job, D.; Douce, R.; Dumas, R.
Allosteric activation of Arabidopsis threonine synthase by S-adenosylmethionine
Biochemistry
37
13212-13221
1998
BRENDA: Arabidopsis thaliana
Textmining: Arabidopsis, Escherichia coli, plant
Muhitch, M.J.
Effects of expressing E. coli threonine synthase in tobacco (Nicotiana tabacum L.) suspension culture cells on free amino acid levels, aspartate pathway enzyme activities and uptake of aspartate into the cells
Plant Physiol.
150
16-22
1997
Escherichia coli
-
Thomazeau, K.; Curien, G.; Thompson, A.; Dumas, R.; Biou, V.
MAD on threonine synthase: the phasing power of oxidized selenomethionine
Acta Crystallogr. Sect. D
57
1337-1340
2001
Arabidopsis thaliana
Curien, G.; Ravanel, S.; Dumas, R.
A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana
Eur. J. Biochem.
270
4615-4627
2003
Arabidopsis thaliana
Garrido-Franco, M.; Ehlert, S.; Messerschmidt, A.; Marinkovic, S.; Huber, R.; Laber, B.; Bourenkov, G.P.; Clausen, T.
Structure and function of threonine synthase from yeast
J. Biol. Chem.
277
12396-12405
2002
BRENDA: Saccharomyces cerevisiae
Textmining: Bacteria, Fungi, Mammalia
Omi, R.; Goto, M.; Miyahara, I.; Mizuguchi, H.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.
Crystal structures of threonine synthase from Thermus thermophilus HB8: conformational change, substrate recognition, and mechanism
J. Biol. Chem.
278
46035-46045
2003
BRENDA: Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Textmining: Thermus thermophilus HB8
Thomazeau, K.; Curien, G.; Dumas, R.; Biou, V.
Crystal structure of threonine synthase from Arabidopsis thaliana
Protein Sci.
10
638-648
2001
Arabidopsis thaliana (Q9S7B5), Arabidopsis thaliana
Fernandez, M.; Cuadrado, Y.; Aparicio, J.F.; Martin, J.F.
Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331
Microbiology
150
1467-1474
2004
Streptomyces
Lee, M.; Martin, M.N.; Hudson, A.O.; Lee, J.; Muhitch, M.J.; Leustek, T.
Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana
Plant J.
41
685-696
2005
Escherichia coli
Mas-Droux, C.; Biou, V.; Dumas, R.
Allosteric threonine synthase. Reorganization of the pyridoxal phosphate site upon asymmetric activation through S-adenosylmethionine binding to a novel site
J. Biol. Chem.
281
5188-5196
2006
BRENDA: Arabidopsis thaliana (Q9S7B5), Arabidopsis thaliana
Textmining: plant
Avraham, T.; Amir, R.
The expression level of threonine synthase and cystathionine-gamma-synthase is influenced by the level of both threonine and methionine in Arabidopsis plants
Transgenic Res.
14
299-311
2005
BRENDA: Arabidopsis sp.
Textmining: Arabidopsis, plant
Kingsbury, J.M.; McCusker, J.H.
Threonine biosynthetic genes are essential in Cryptococcus neoformans
Microbiology
154
2767-2775
2008
Cryptococcus neoformans
Graham, D.E.; Taylor, S.M.; Wolf, R.Z.; Namboori, S.C.
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase
Biochem. J.
424
467-478
2009
BRENDA: Methanosarcina acetivorans C2A
Textmining: Methanosarcinales, Escherichia coli, insertion sequences, Archaea, Methanocaldococcus jannaschii, Methanomicrobiales, Methanosarcina acetivorans (Q8TKU7), Methanosarcina acetivorans
Sikdar, M.; Kim, J.
Functional analysis of a gene encoding threonine synthase from rice
Afr. J. Biotechnol.
9
1122-1129
2010
Oryza sativa
-
Murakawa, T.; Machida, Y.; Hayashi, H.
Product-assisted catalysis as the basis of the reaction specificity of threonine synthase
J. Biol. Chem.
286
2774-2784
2011
Thermus thermophilus (Q5SL02), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SL02)
Kingsbury, J.M.; McCusker, J.H.
Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation
Eukaryot. Cell
9
729-737
2010
Saccharomyces cerevisiae, Cryptococcus neoformans, Mus sp.
Covarrubias, A.S.; Hgbom, M.; Bergfors, T.; Carroll, P.; Mannerstedt, K.; Oscarson, S.; Parish, T.; Jones, T.A.; Mowbray, S.L.
Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis
J. Mol. Biol.
381
622-633
2008
BRENDA: Mycobacterium tuberculosis (P9WG59), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG59)
Textmining: Bacteria, Thermus thermophilus, Embryophyta, Mammalia
Morneau, D.J.; Abouassaf, E.; Skanes, J.E.; Aitken, S.M.
Development of a continuous assay and steady-state characterization of Escherichia coli threonine synthase
Anal. Biochem.
423
78-85
2012
BRENDA: Escherichia coli
Textmining: Lactobacillus delbrueckii, Phyla, Siproeta stelenes
Shoji, M.; Hanaoka, K.; Ujiie, Y.; Tanaka, W.; Kondo, D.; Umeda, H.; Kamoshida, Y.; Kayanuma, M.; Kamiya, K.; Shiraishi, K.; Machida, Y.; Murakawa, T.; Hayashi, H.
A QM/MM study of the L-threonine formation reaction of threonine synthase: implications into the mechanism of the reaction specificity
J. Am. Chem. Soc.
136
4525-4533
2014
Thermus thermophilus
Morneau, D.J.; Jaworski, A.F.; Aitken, S.M.
Identification of cystathionine gamma-synthase and threonine synthase from Cicer arietinum and Lens culinaris
Biochem. Cell Biol.
91
95-101
2013
Cicer arietinum (L0EK12), Cicer arietinum, Lens culinaris (L0EKR2), Lens culinaris, Escherichia coli, Arabidopsis thaliana, Glycine max, plant
Kaur, G.; Subramanian, S.
Evolutionary analysis of a novel zinc ribbon in the N-terminal region of threonine synthase
Cell Cycle
16
1918-1926
2017
Aquifex aeolicus (O66740), Escherichia coli (P00934), Saccharomyces cerevisiae (P16120), Thermus thermophilus (P83823), Thermus thermophilus (Q5SL02), Mycobacterium tuberculosis (P9WG59), Burkholderia thailandensis (Q2SWH9), Brucella melitensis (Q8YFS0), Arabidopsis thaliana (Q9S7B5), Brucella melitensis 16M (Q8YFS0), Burkholderia thailandensis ATCC 700388 (Q2SWH9), Mycobacterium tuberculosis H37Rv (P9WG59)
Manucharian, KG; Gening, LV; Gusiatiner, MM; Gazarian, KG
[Design of a gene coding encoding a polypeptide, mixing the enzyme activity of Escherichia coli homoserine kinase and threonine synthetase]
Mol Gen Mikrobiol Virusol
12-5
1991
Escherichia coli
Han, KS; Archer, JA; Sinskey, AJ
The molecular structure of the Corynebacterium glutamicum threonine synthase gene.
Mol Microbiol
4
1693-702
1990
Corynebacterium glutamicum
Aas, SF; Rognes, SE
Nucleotide sequence of the yeast THR4 gene encoding threonine synthase.
Nucleic Acids Res
18
665
1990
Saccharomyces cerevisiae
Malumbres, M; Mateos, LM; Guerrero, C; Martín, JF
Nucleotide sequence of the threonine synthase (thrC) gene of Brevibacterium lactofermentum.
Nucleic Acids Res
16
9859
1988
Corynebacterium glutamicum
Savageau, MA; Steward, JP
Repression of the threonine synthetase system in Escherichia coli.
Arch Biochem Biophys
137
181-4
1970
Escherichia coli
Laber, B; Lindell, SD; Pohlenz, HD
Inactivation of Escherichia coli threonine synthase by DL-Z-2-amino-5-phosphono-3-pentenoic acid.
Arch Microbiol
161
400-3
1994
Escherichia coli
Ramos, C; Calderón, IL
Biochemical evidence that the Saccharomyces cerevisiae THR4 gene encodes threonine synthetase.
FEBS Lett
351
357-9
1994
Saccharomyces cerevisiae
Motoyama, H; Maki, K; Anazawa, H; Ishino, S; Teshiba, S
Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the gram-negative obligate methylotroph Methylobacillus glycogenes.
Appl Environ Microbiol
60
111-9
1994
Methylobacillus glycogenes
Rees, WD; Hay, SM
The expression of Escherichia coli threonine synthase and the production of threonine from homoserine in mouse 3T3 cells.
Biochem J
291 ( Pt 1)
315-22
1993
Escherichia coli, Mus musculus
Bartlem, D; Lambein, I; Okamoto, T; Itaya, A; Uda, Y; Kijima, F; Tamaki, Y; Nambara, E; Naito, S
Mutation in the threonine synthase gene results in an over-accumulation of soluble methionine in Arabidopsis.
Plant Physiol
123
101-10
2000
Arabidopsis
Casazza, AP; Basner, A; Höfgen, R; Hesse, H
Expression of threonine synthase from Solanum tuberosum L. is not metabolically regulated by photosynthesis-related signals or by nitrogenous compounds.
PLANT SCIENCE
157
43-50
2000
Solanum tuberosum, Escherichia coli, Arabidopsis thaliana
Zeh, M; Casazza, AP; Kreft, O; Roessner, U; Bieberich, K; Willmitzer, L; Hoefgen, R; Hesse, H
Antisense inhibition of threonine synthase leads to high methionine content in transgenic potato plants.
Plant Physiol
127
792-802
2001
Solanum tuberosum
Tang, DW; Li, LF; Yu, YM; Liu, XY; Su, XD; Zhao, X; Liang, YH
Preparation, crystallization and preliminary X-ray analysis of threonine synthase from Streptococcus mutans.
Protein Pept Lett
14
836-8
2007
Streptococcus mutans
Harata, K; Okuno, T
Threonine synthase CoTHR4 is involved in infection-related morphogenesis during the pre-penetration stage in Colletotrichum orbiculare.
Microb Pathog
103746
2019
Colletotrichum orbiculare, Agrobacterium, Saccharomyces cerevisiae, Transformation
Meshram, RJ; Bagul, KT; Aouti, SU; Shirsath, AM; Duggal, H; Gacche, RN
Modeling and simulation study to identify threonine synthase as possible drug target in Leishmania major.
Mol Divers
2020
Leishmania major
Goto, DB; Ogi, M; Kijima, F; Kumagai, T; van Werven, F; Onouchi, H; Naito, S
A single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana.
Genes Genet Syst
77
89-95
2002
Arabidopsis thaliana
Ong, HB; Lee, WS; Patterson, S; Wyllie, S; Fairlamb, AH
Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.
Mol Microbiol
95
143-56
2015
Trypanosoma brucei, Bacteria, Fungi, Glossina, Wigglesworthia, Transformation
Rattanama, P; Thompson, JR; Kongkerd, N; Srinitiwarawong, K; Vuddhakul, V; Mekalanos, JJ
Sigma E Regulators Control Hemolytic Activity and Virulence in a Shrimp Pathogenic Vibrio harveyi.
PLoS One
7
e32523
2012
transposons
Dilger, M; Felsenstein, FG; Schwarz, G
Identification and quantitative expression analysis of genes that are differentially expressed during conidial germination in Pyrenophora teres.
Mol Genet Genomics
270
147-55
2003
Ascomycota
Gururani, K; Kumar, A; Tiwari, A; Agarwal, A; Gupta, S; Pandey, D
Transcriptome wide identification and characterization of regulatory genes involved in EAA metabolism and validation through expression analysis in different developmental stages of finger millet spikes.
3 Biotech
10
347
2020
Eleusine coracana
Jander, G; Joshi, V
Aspartate-Derived Amino Acid Biosynthesis in Arabidopsis thaliana.
Arabidopsis Book
7
e0121
2009
plant
Clepet, C; Borne, F; Krishnapillai, V; Baird, C; Patte, JC; Cami, B
Isolation, organization and expression of the Pseudomonas aeruginosa threonine genes.
Mol Microbiol
6
3109-19
1992
Pseudomonas aeruginosa
Mannhaupt, G; van der Linden, G; Vetter, I; Maurer, K; Pilz, U; Planta, R; Feldmann, H
Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae.
Yeast
6
353-61
0
Saccharomyces cerevisiae, Escherichia coli
Follettie, MT; Shin, HK; Sinskey, AJ
Organization and regulation of the Corynebacterium glutamicum hom-thrB and thrC loci.
Mol Microbiol
2
53-62
1988
Corynebacterium glutamicum
Altmann-Jöhl, R; Philippsen, P
AgTHR4, a new selection marker for transformation of the filamentous fungus Ashbya gossypii, maps in a four-gene cluster that is conserved between A. gossypii and Saccharomyces cerevisiae.
Mol Gen Genet
250
69-80
1996
Saccharomyces cerevisiae
Malumbres, M; Mateos, LM; Guerrero, C; Martín, JF
Molecular cloning of the hom-thrC-thrB cluster from Bacillus sp. ULM1: expression of the thrC gene in Escherichia coli and corynebacteria, and evolutionary relationships of the threonine genes.
Folia Microbiol (Praha)
40
595-606
1995
Bacillus sp. (in: Bacteria)
Marchenko, GN; Marchenko, ND; Tsygankov, YD; Chistoserdov, AY
Organization of threonine biosynthesis genes from the obligate methylotroph Methylobacillus flagellatus.
Microbiology
145 ( Pt 11)
3273-82
1999
Methylobacillus flagellatus
Nikiforova, V; Kempa, S; Zeh, M; Maimann, S; Kreft, O; Casazza, AP; Riedel, K; Tauberger, E; Hoefgen, R; Hesse, H
Engineering of cysteine and methionine biosynthesis in potato.
Amino Acids
22
259-78
2002
Arabidopsis, Solanum tuberosum
Aarnes, H
Regulation of threonine biosynthesis in barley seedlings (Hordeum vulgare L.).
Planta
140
185-92
1978
Hordeum vulgare
Zhang, Y; Dai, Z; Wu, G; Zhang, R; Dai, Y; Li, N
Expression of threonine-biosynthetic genes in mammalian cells and transgenic mice.
Amino Acids
46
2177-88
2014
Mus musculus, Escherichia coli, plasmids
Petronikolou, N; Ortega, MA; Borisova, SA; Nair, SK; Metcalf, WW
Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin.
ACS Chem Biol
14
742-750
2019
Bacillus subtilis
Donini, S; Percudani, R; Credali, A; Montanini, B; Sartori, A; Peracchi, A
A threonine synthase homolog from a mammalian genome.
Biochem Biophys Res Commun
350
922-8
2006
vertebrata, Metazoa
Gahungu, M; Arguelles-Arias, A; Fickers, P; Zervosen, A; Joris, B; Damblon, C; Luxen, A
Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin A.
Bioorg Med Chem
21
4958-67
2013
Bacillus subtilis NRS 231, Bacteria, Fungi, Streptomyces plumbeus
Cami, B; Clepet, C; Patte, JC
Evolutionary comparisons of three enzymes of the threonine biosynthetic pathway among several microbial species.
Biochimie
75
487-95
1993
Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Corynebacterium glutamicum, Saccharomyces cerevisiae
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