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Information on EC 4.2.1.96 - 4a-hydroxytetrahydrobiopterin dehydratase and Organism(s) Drosophila melanogaster

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase
IUBMB Comments
In concert with EC 1.5.1.34, 6,7-dihydropteridine reductase, the enzyme recycles 4a-hydroxytetrahydrobiopterin back to tetrahydrobiopterin, a cosubstrate for several enzymes, including aromatic amino acid hydroxylases. The enzyme is bifunctional, and also acts as a dimerization cofactor of hepatocyte nuclear factor-1alpha (HNF-1).
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Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
pcd/dcoh, pterin-4a-carbinolamine dehydratase, dcoh/pcd, dcoh2, dcohalpha, xdcoh, 4a-carbinolamine dehydratase, pterin-4alpha-carbinolamine dehydratase, pterin-4 alpha-carbinolamine dehydratase, cdcoh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 alpha-Hydroxy-tetrahydropterin dehydratase
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4-alpha-hydroxy-tetrahydropterin dehydratase
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4a-Carbinolamine dehydratase
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4a-Hydroxytetrahydrobiopterin dehydratase
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4a-Hydroxytetrahydropterin dehydratase
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cDcoH
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DCoH
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DCoH/PCD
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Dehydratase, 4a-carbinolamine
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Dimerization cofactor of hepatocyte nuclear factor 1-alpha
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Dimerization cofactor of HNF1
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Dimerization factor of HNF1/pterin-4alpha-carbinolamine dehydratase
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GenBank AE000671-derived protein GI 2982796
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P4aCD
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PCD
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PCD/DCoH
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PCD/PhhB
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PCDH
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Phenylalanine hydroxylase-stimulating protein
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Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase
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PHS
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PHS/PCD
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Pterin carbinolamine dehydratase
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Pterin-4 alpha-carbinolamine dehydratase
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Pterin-4-alpha-carbinolamine dehydratase
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Pterin-4a-carbinolamine dehydratase
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Pterin-4a-carbinolamine dehydratase (Aquifex aeolicus gene phhB)
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Pterin-4a-carbinolamine dehydratase/dimerization cofactor of HNF1
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Pterin-4alpha-carbinolamine dehydratase
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Pterin-4alpha-carbinolamine dehydratase (PCD)/dimerization cofactor for the transcription factor HBF-1alpha
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XDCoH
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination of H2O
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
4a-hydroxytetrahydrobiopterin hydro-lyase (6,7-dihydrobiopterin-forming)
In concert with EC 1.5.1.34, 6,7-dihydropteridine reductase, the enzyme recycles 4a-hydroxytetrahydrobiopterin back to tetrahydrobiopterin, a cosubstrate for several enzymes, including aromatic amino acid hydroxylases. The enzyme is bifunctional, and also acts as a dimerization cofactor of hepatocyte nuclear factor-1alpha (HNF-1).
CAS REGISTRY NUMBER
COMMENTARY hide
204788-56-7
pterin-4a-carbinolamine dehydratase (Aquifex aeolicus gene phhB), genBank AE000671-derived protein GI 2982796
87683-70-3
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PHS_DROME
192
0
21067
Swiss-Prot
Mitochondrion (Reliability: 5)