Reference on EC 4.2.1.75 - uroporphyrinogen-III synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hart, G.J.; Battersby, A.R.
Purification and properties of uroporphyrinogen III synthase (co-synthase) from Euglena gracilis
Biochem. J.
232
151-160
1985
Euglena gracilis
Tsai, S.F.; Bishop, D.F.; Desnick, R.J.
Purification and properties of uroporphyrinogen III synthase from human erythrocytes
J. Biol. Chem.
262
1268-1273
1987
Homo sapiens
Clement, R.P.; Kohashi, M.; Piper, W.N.
Rat hepatic uroporphyrinogen III cosynthase: Purification, properties and inhibition by metal ions
Arch. Biochem. Biophys.
214
657-667
1982
Rattus norvegicus
Kohashi, M.; Clement, R.P.; Tse, J.; Piper, W.N.
Rat hepatic uroporphyrinogen III co-synthase. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroprphyrinogen III
Biochem. J.
220
755-765
1984
Rattus norvegicus
Alwan, A.F.; Jordan, P.M.
Isolation of uroporphyrinogen III synthase from Escherichia coli
Biochem. Soc. Trans.
16
965-966
1988
Escherichia coli
-
Smythe, E.; Williams, D.C.
Rat liver uroporphyrinogen III synthase has similar properties to the enzyme from Euglena gracilis, including absence of a requirement for a reversibly bound cofactor for activity
Biochem. J.
253
275-279
1988
Rattus norvegicus
Levin, E.Y.
Enzymatic properties of uroporphyrinogen III cosynthetase
Biochemistry
10
4669-4675
1971
Mus musculus
Wright, D.J.; Lim, C.K.
Simultaneous determination of hydroxymethylbilane synthase and uroporphyrinogen III synthase in erythrocytes by high-performance liquid chromatography
Biochem. J.
213
85-88
1983
Homo sapiens
Frydman, R.B.; Feinstein, G.
Studies on porphobilinogen deaminase and uroporphyrinogen III cosynthase from human erythrocytes
Biochim. Biophys. Acta
350
358-373
1974
Homo sapiens
Stevens, E.; Frydman, B.
Isolation and properties of wheat germ uroporphyrinogen III cosynthase
Biochim. Biophys. Acta
151
429-437
1968
Triticum aestivum
Jordan, P.M.; Berry, A.
Preuroporphyrinogen, a universal intermediate in the biosynthesis of uroporphyrinogen III
FEBS Lett.
112
86-88
1980
Saccharomyces cerevisiae, Gallus gallus, Cereibacter sphaeroides
Sasarman, A.; Nepveu, A.; Echelard, Y.; Dymetryszyn, J.; Drolet, M.; Goyer, C.
Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the uro operon
J. Bacteriol.
169
4257-4262
1987
Escherichia coli
Stamford, N.P.J.; Capretta, A.; Battersby, A.R.
Expression, purification and characterisation of the product from the Bacillus subtilis hemD gene, uroporphyrinogen III synthase
Eur. J. Biochem.
231
236-241
1995
Bacillus subtilis
Alwan, A.F.; Mgbeje, B.I.A.; Jordan, P.M.
Purification and properties of uroporphyrinogen III synthase (co-synthase) from an overproducing recombinant strain of Escherichia coli K-12
Biochem. J.
264
397-402
1989
Escherichia coli
Kohashi, M.
Folate binding protein in the heme biosynthesis. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroporphyrinogen III
Vitamins (Kyoto)
62
541-547
1988
Rattus norvegicus
-
Stark, W.M.; Hawker, C.J.; Hart, G.J.; Philippides, A.; Petersen, P.M.; Lewis, J.D.; Leeper, F.J.; Battersby, A.R.
Biosnthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro intermediate for porphyrin biosynthesis: Inhibition of cosynthetase
J. Chem. Soc. Perkin Trans. I
1993
2875-2892
1993
Euglena gracilis
-
Stark, W.M.; Hart, G.J.; Battersby, A.R.
Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: Inhibition of cosynthetase
J. Chem. Soc. Chem. Commun.
1986
465-467
1986
Euglena gracilis
-
Schubert, H.L.; Raux, E.; Matthews, M.A.; Phillips, J.D.; Wilson, K.S.; Hill, C.P.; Warren, M.J.
Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase
Biochem. Soc. Trans.
30
595-600
2002
Homo sapiens
Mathews, M.A.; Schubert, H.L.; Whitby, F.G.; Alexander, K.J.; Schadick, K.; Bergonia, H.A.; Phillips, J.D.; Hill, C.P.
Crystal structure of human uroporphyrinogen III synthase
EMBO J.
20
5832-5839
2001
Homo sapiens (P10746), Homo sapiens
Roessner, C.A.; Ponnamperuma, K.; Scott, A.I.
Mutagenesis identifies a conserved tyrosine residue important for the activity of uroporphyrinogen III synthase from Anacystis nidulans
FEBS Lett.
525
25-28
2002
Synechococcus elongatus PCC 7942 = FACHB-805
Bishop, D.F.; Johansson, A.; Phelps, R.; Shady, A.A.; Ramirez, M.C.; Yasuda, M.; Caro, A.; Desnick, R.J.
Uroporphyrinogen III synthase knock-in mice have the human congenital erythropoietic porphyria phenotype, including the characteristic light-induced cutaneous lesions
Am. J. Hum. Genet.
78
645-658
2006
Mus musculus (P51163), Mus musculus
Omata, Y.; Sakamoto, H.; Higashimoto, Y.; Hayashi, S.; Noguchi, M.
Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli
J. Biochem.
136
211-220
2004
Homo sapiens (P10746), Homo sapiens
Hanaoka, R.; Dawid, I.B.; Kawahara, A.
Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO)
DNA Seq.
18
54-60
2007
Danio rerio (Q1ET39), Danio rerio
Wiederholt, T.; Poblete-Gutierrez, P.; Gardlo, K.; Goerz, G.; Bolsen, K.; Merk, H.F.; Frank, J.
Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyria
Physiol. Res.
55
S85-S92
2006
Homo sapiens
-
Li, N.; Ma, D.L.; Liu, X.; Wu, L.; Chu, X.; Wong, K.Y.; Li, D.
Characterization of His-tagged rat uroporphyrinogen III synthase wild-type and variant enzymes
Protein J.
26
569-576
2007
Rattus norvegicus
Cunha, L.; Kuti, M.; Bishop, D.F.; Mezei, M.; Zeng, L.; Zhou, M.M.; Desnick, R.J.
Human uroporphyrinogen III synthase: NMR-based mapping of the active site
Proteins
71
855-873
2007
Homo sapiens (P10746), Homo sapiens
Tan, F.; Cheng, Q.; Saha, K.; Heinemann, I.U.; Jahn, M.; Jahn, D.; Smith, A.G.
Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase
Biochem. J.
410
291-299
2008
Arabidopsis thaliana (O48721), Arabidopsis thaliana
Schubert, H.L.; Phillips, J.D.; Heroux, A.; Hill, C.P.
Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex
Biochemistry
47
8648-8655
2008
Thermus thermophilus (Q72KM1), Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q72KM1)
Fortian, A.; Castano, D.; Ortega, G.; Lain, A.; Pons, M.; Millet, O.
Uroporphyrinogen III synthase mutations related to congenital erythropoietic porphyria identify a key helix for protein stability
Biochemistry
48
454-461
2009
Homo sapiens (P10746), Homo sapiens
Vargas, P.D.; Furuyama, K.; Sassa, S.; Shibahara, S.
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway
FEBS J.
275
5947-5959
2008
Homo sapiens
Silva, P.J.; Ramos, M.J.
Comparative density functional study of models for the reaction mechanism of uroporphyrinogen III synthase
J. Phys. Chem. B
112
3144-3148
2008
Homo sapiens (P10746)
Bishop, D.F.; Schneider-Yin, X.; Clavero, S.; Yoo, H.W.; Minder, E.I.; Desnick, R.J.
Congenital erythropoietic porphyria: a novel uroporphyrinogen III synthase branchpoint mutation reveals underlying wild-type alternatively spliced transcripts
Blood
115
1062-1069
2010
Homo sapiens
Clavero, S.; Bishop, D.F.; Haskins, M.E.; Giger, U.; Kauppinen, R.; Desnick, R.J.
Feline acute intermittent porphyria: a phenocopy masquerading as an erythropoietic porphyria due to dominant and recessive hydroxymethylbilane synthase mutations
Hum. Mol. Genet.
19
584-596
2010
Felis catus
Kang, T.; Oh, S.; Kim, M.; Lee, J.; Kim, S.
Compound heterozygosity for a premature termination codon and missense mutation in the exon 10 of the uroporphyrinogen III cosynthase gene causes a severe phenotype of congenital erythropoietic porphyria
J. Eur. Acad. Dermatol. Venereol.
23
470-471
2009
Homo sapiens
Ayliffe, M.A.; Agostino, A.; Clarke, B.C.; Furbank, R.; von Caemmerer, S.; Pryor, A.J.
Suppression of the barley uroporphyrinogen III synthase gene by a Ds activation tagging element generates developmental photosensitivity
Plant Cell
21
814-831
2009
Hordeum vulgare
Fortian, A.; Castano, D.; Gonzalez, E.; Lain, A.; Falcon-Perez, J.M.; Millet, O.
Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase: Molecular basis of congenital erythropoietic porphyria
Adv. Protein Chem. Struct. Biol.
83
43-74
2011
Homo sapiens, Pseudomonas syringae (Q88B90)
Peng, S.; Zhang, H.; Gao, Y.; Pan, X.; Cao, P.; Li, M.; Chang, W.
Crystal structure of uroporphyrinogen III synthase from Pseudomonas syringae pv. tomato DC3000
Biochem. Biophys. Res. Commun.
408
576-581
2011
Pseudomonas syringae (Q88B90), Pseudomonas syringae, Pseudomonas syringae DC3000 (Q88B90)
Vannini, V.; Rodriguez, A.; Vera, J.L.; de Valdez, G.F.; Taranto, M.P.; Sesma, F.
Cloning and heterologous expression of Lactobacillus reuteri uroporphyrinogen III synthase/methyltransferase gene (cobA/hemD): preliminary characterization
Biotechnol. Lett.
33
1625-1632
2011
Limosilactobacillus reuteri (Q50EH6), Limosilactobacillus reuteri CRL 1098 (Q50EH6)
Fortian, A.; Gonzalez, E.; Castano, D.; Falcon-Perez, J.M.; Millet, O.
Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R
J. Biol. Chem.
286
13127-13133
2011
Homo sapiens
Ben Bdira, F.; Gonzalez, E.; Pluta, P.; Lain, A.; Sanz-Parra, A.; Falcon-Perez, J.M.; Millet, O.
Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria
Hum. Mol. Genet.
23
5805-5813
2014
Homo sapiens (P10746), Homo sapiens
Moghbeli, M.; Maleknejad, M.; Arabi, A.; Abbaszadegan, M.R.
Mutational analysis of uroporphyrinogen III cosynthase gene in Iranian families with congenital erythropoietic porphyria
Mol. Biol. Rep.
39
6731-6735
2012
Homo sapiens (P10746), Homo sapiens
Aguilera, P.; Badenas, C.; Whatley, S.D.; To-Figueras, J.
Late-onset cutaneous porphyria in a patient heterozygous for a uroporphyrinogen III synthase gene mutation
Br. J. Dermatol.
175
1346-1350
2016
Homo sapiens (P10746), Homo sapiens
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