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Information on EC 4.2.1.59 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase and Organism(s) Pseudomonas aeruginosa

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
IUBMB Comments
This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates .
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This record set is specific for:
Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
3-hydroxyacyl-acp dehydratase, hahad1, hahad2, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Beta-hydroxyoctanoyl-ACP-dehydrase
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Beta-Hydroxyoctanoyl-acyl carrier protein dehydrase
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D-3-Hydroxyoctanoyl-acyl carrier protein dehydratase
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Dehydratase, beta-hydroxyoctanoyl thioester
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Dehydratase, D-3-hydroxyoctanoyl-[acyl carrier protein]
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FabA
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FabZ
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates [4].
CAS REGISTRY NUMBER
COMMENTARY hide
9030-85-7
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8G4N1D0_PSEAI
146
0
16773
TrEMBL
-
A0A8G4GYX3_PSEAI
146
0
16764
TrEMBL
-
A0A8G4A9N1_PSEAI
146
0
16764
TrEMBL
-
A0A8G4A4B0_PSEAI
171
0
18776
TrEMBL
-
A0A8G2ZF95_PSEAI
146
0
16793
TrEMBL
-
A0A8G3QSH7_PSEAI
146
0
16716
TrEMBL
-
A0A072ZI65_PSEAI
171
0
18748
TrEMBL
-
A0A8G6LWG1_PSEAI
171
0
18703
TrEMBL
-
A0A069QFG1_PSEAI
146
0
16774
TrEMBL
-
A0A8G2VZJ6_PSEAI
146
0
16740
TrEMBL
-
A0A8G7FHV9_PSEAI
146
0
16772
TrEMBL
-
A0A8G6RXW3_PSEAI
171
0
18778
TrEMBL
-
A0A8G7S2J8_PSEAI
146
0
16764
TrEMBL
-