Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 4.2.1.59 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC4.2.1.59
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
IUBMB Comments
This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates .
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
3-hydroxyacyl-acp dehydratase, hahad1, hahad2, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Beta-hydroxyoctanoyl-ACP-dehydrase
-
-
-
-
Beta-Hydroxyoctanoyl-acyl carrier protein dehydrase
-
-
-
-
D-3-Hydroxyoctanoyl-acyl carrier protein dehydratase
-
-
-
-
Dehydratase, beta-hydroxyoctanoyl thioester
-
-
-
-
Dehydratase, D-3-hydroxyoctanoyl-[acyl carrier protein]
-
-
-
-
FabA
-
-
-
-
FabZ
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates [4].
CAS REGISTRY NUMBER
COMMENTARY hide
9030-85-7
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HTD2_HUMAN
168
0
18559
Swiss-Prot
Mitochondrion (Reliability: 3)
FAS_HUMAN
2511
0
273427
Swiss-Prot
other Location (Reliability: 2)
A0A0U1RQF0_HUMAN
2509
0
273198
TrEMBL
other Location (Reliability: 2)
FAS_HUMAN
2511
0
273427
Swiss-Prot
Mitochondrion (Reliability: 5)