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Information on EC 4.2.1.17 - enoyl-CoA hydratase and Organism(s) Mus musculus

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.17 enoyl-CoA hydratase
IUBMB Comments
Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 4.2.1.74 long-chain-enoyl-CoA hydratase.
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Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
enoyl-coa hydratase, echs1, peroxisomal bifunctional enzyme, 2-enoyl-coa hydratase, amech, short-chain enoyl-coa hydratase, enoyl-coa hydratase/isomerase, beta-hydroxyacyl-coa dehydrase, enoyl-coenzyme a hydratase, enoyl coenzyme a hydratase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-enoyl-CoA hydratase
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-
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2-octenoyl coenzyme A hydrase
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-
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acyl coenzyme A hydrase
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-
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beta-hydroxyacid dehydrase
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-
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beta-hydroxyacyl-CoA dehydrase
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-
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crotonase
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-
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crotonyl hydrase
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-
-
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D-3-hydroxyacyl-CoA dehydratase
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-
-
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ECH
-
-
-
-
ECH1
-
-
ECHS1
-
-
enol-CoA hydratase
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-
-
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Enoyl coenzyme A hydrase (D)
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-
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enoyl coenzyme A hydrase (L)
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enoyl coenzyme A hydratase
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-
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enoyl coenzyme A hydratase 1
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enoyl hydrase
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enoyl-CoA hydratase
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hydratase, enoyl coenzyme A
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-
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SCEH
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short chain enoyl coenzyme A hydratase
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-
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short-chain enoyl-CoA hydratase
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-
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trans-2-enoyl-CoA hydratase
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unsaturated acyl-CoA hydratase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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-
-
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hydration
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-
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-
SYSTEMATIC NAME
IUBMB Comments
(3S)-3-hydroxyacyl-CoA hydro-lyase
Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 4.2.1.74 long-chain-enoyl-CoA hydratase.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-13-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
a hepatocarcinoma cell line. Expression of Ech1 is upregulated in the Hca-F cell line
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ECHA_MOUSE
763
0
82670
Swiss-Prot
Mitochondrion (Reliability: 1)
ECHM_MOUSE
290
0
31474
Swiss-Prot
Mitochondrion (Reliability: 1)
ECHP_MOUSE
718
0
78301
Swiss-Prot
other Location (Reliability: 3)
Q7M0E0_MOUSE
14
0
1572
TrEMBL
other Location (Reliability: 1)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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ECHS1 down-regulation contributes to high-fat diet-induced hepatic steatosis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hiromasa, Y.; Yan, X.; Roche, T.E.
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r
Biochemistry
47
2312-2324
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Zhang, J.; Song, M.; Wang, J.; Sun, M.; Wang, B.; Li, R.; Huang, Y.; Hou, L.; Jin, Y.; Wang, M.; Tang, J.
Enoyl coenzyme A hydratase 1 is an important factor in the lymphatic metastasis of tumors
Biomed. Pharmacother.
65
157-162
2011
Mus musculus
Manually annotated by BRENDA team