Information on EC 4.2.1.1 - carbonic anhydrase and Organism(s) Arabidopsis thaliana

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Arabidopsis thaliana


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea


The taxonomic range for the selected organisms is: Arabidopsis thaliana

EC NUMBER
COMMENTARY hide
4.2.1.1
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RECOMMENDED NAME
GeneOntology No.
carbonic anhydrase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
addition
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-
-
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elimination
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-hydroxypropanoate cycle
-
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3-hydroxypropanoate/4-hydroxybutanate cycle
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C4 photosynthetic carbon assimilation cycle, NAD-ME type
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C4 photosynthetic carbon assimilation cycle, NADP-ME type
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C4 photosynthetic carbon assimilation cycle, PEPCK type
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CO2 fixation into oxaloacetate (anaplerotic)
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cyanate degradation
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gluconeogenesis II (Methanobacterium thermoautotrophicum)
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glyoxylate assimilation
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cyanate degradation
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Nitrogen metabolism
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SYSTEMATIC NAME
IUBMB Comments
carbonic acid hydro-lyase (carbon-dioxide-forming)
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-03-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
H2CO3
show the reaction diagram
H2CO3
CO2 + H2O
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
H2CO3
CO2 + H2O
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetazolamide
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at 0.5 mM inhibition of the cabonic anhydrase activity of the high molecular mass protein and stimulation of activity of the low molecular mass carrier in the PSII-membranes. At 0.5 mM acetazolamide moderately inhibits the carbonic anhydrase activity of PSI membranes
ethoxyzolamide
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.4
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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functional carbonic anhydrase genes are more strongly expressed in green tissue, but strong expression is also found in roots for alphaCA2; functional carbonic anhydrase genes are more strongly expressed in green tissue, but strong expression is also found in roots for betaCA3 and betaCA6
Manually annotated by BRENDA team
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functional carbonic anhydrase genes are more strongly expressed in green tissue, but strong expression is also found in roots for alphaCA2; functional carbonic anhydrase genes are more strongly expressed in green tissue, but strong expression is also found in roots for betaCA3, betaCA6
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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betaCA2 and betaCA3 are targeted to the cytosol
Manually annotated by BRENDA team
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betaCA6 is targeted to the mitochondria
Manually annotated by BRENDA team
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betaCA4 is targeted to the plasma membrane
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloned and overexpressed
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Q158A
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site-directed variant
Y212F
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site-directed variant