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Information on EC 4.1.3.4 - hydroxymethylglutaryl-CoA lyase and Organism(s) Rattus norvegicus

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.4 hydroxymethylglutaryl-CoA lyase
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Rattus norvegicus
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
hmg-coa lyase, hmgcl, 3-hydroxy-3-methylglutaryl-coa lyase, 3-hydroxy-3-methylglutaryl-coenzyme a lyase, hmgcll1, 3-hydroxy-3-methylglutaryl coenzyme a lyase, hydroxymethylglutaryl-coa lyase, 3-hydroxy-3-methylglutaryl coa lyase, hmg coa lyase, liue protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-hydroxy-3-methylglutarate-CoA lyase
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-
-
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3-Hydroxy-3-methylglutaryl CoA cleaving enzyme
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-
-
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3-Hydroxy-3-methylglutaryl coenzyme A lyase
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-
-
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3-Hydroxy-3-methylglutaryl-CoA lyase
HMG CoA cleavage enzyme
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HMG-CoA lyase
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-
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Hydroxymethylglutaryl coenzyme A lyase
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Hydroxymethylglutaryl coenzyme A-cleaving enzyme
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SYSTEMATIC NAME
IUBMB Comments
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9030-83-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-3-Hydroxy-3-methylglutaryl-CoA
?
show the reaction diagram
(S)-3-Hydroxy-3-methylglutaryl-CoA
Acetyl-CoA + acetoacetate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(S)-3-Hydroxy-3-methylglutaryl-CoA
?
show the reaction diagram
(S)-3-Hydroxy-3-methylglutaryl-CoA
Acetyl-CoA + acetoacetate
show the reaction diagram
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
enzyme assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
13% of activity
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HMGC2_RAT
343
0
36549
Swiss-Prot
other Location (Reliability: 3)
HMGCL_RAT
325
0
34192
Swiss-Prot
Mitochondrion (Reliability: 1)
A0A8I5ZVC0_RAT
311
0
33068
TrEMBL
other Location (Reliability: 3)
A0A8I5ZY90_RAT
331
0
34879
TrEMBL
other Location (Reliability: 4)
A0A8I5ZQC1_RAT
240
0
25529
TrEMBL
other Location (Reliability: 3)
A0A8I6AGX3_RAT
177
0
18892
TrEMBL
other Location (Reliability: 3)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Aragon, J.J.; Lowenstein, J.M.
A survey of enzymes which generate or use acetoacetyl thioesters in rat liver
J. Biol. Chem.
258
4725-4733
1983
Rattus norvegicus
Manually annotated by BRENDA team
Clinkenbeard, K.D.; Reed, W.D.; Mooney, R.A.; Lane, M.D.
Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzyme a cycle enzymes in liver
J. Biol. Chem.
250
3108-3116
1975
Gallus gallus, Rattus norvegicus
Manually annotated by BRENDA team
Leipnitz, G.; Seminotti, B.; Haubrich, J.; Dalcin, M.B.; Dalcin, K.B.; Solano, A.; de Bortoli, G.; Rosa, R.B.; Amaral, A.U.; Dutra-Filho, C.S.; Latini, A.; Wajner, M.
Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex
J. Neurosci. Res.
86
683-693
2008
Rattus norvegicus (P97519)
Manually annotated by BRENDA team
Leipnitz, G.; Seminotti, B.; Fernandes, C.G.; Amaral, A.U.; Beskow, A.P.; da Silva, L.d.e..B.; Zanatta, A.; Ribeiro, C.A.; Vargas, C.R.; Wajner, M.
Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver
Int. J. Dev. Neurosci.
27
351-356
2009
Rattus norvegicus
Manually annotated by BRENDA team